U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Jag2 jagged 2 [ Mus musculus (house mouse) ]

Gene ID: 16450, updated on 13-Feb-2024

Summary

Official Symbol
Jag2provided by MGI
Official Full Name
jagged 2provided by MGI
Primary source
MGI:MGI:1098270
See related
Ensembl:ENSMUSG00000002799 AllianceGenome:MGI:1098270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sm; Serh; D12Ggc2e; mJagged2-1
Summary
Enables Notch binding activity. Involved in auditory receptor cell fate commitment; gamma-delta T cell differentiation; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including epithelial cell apoptotic process involved in palatal shelf morphogenesis; odontogenesis of dentin-containing tooth; and respiratory system process. Located in membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and surface ectoderm. Orthologous to human JAG2 (jagged canonical Notch ligand 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 17.9), ovary adult (RPKM 17.4) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Jag2 in Genome Data Viewer
Location:
12 F1; 12 61.37 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112871439..112893437, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112907803..112929812, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 132 Neighboring gene RIKEN cDNA 1700127F24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114108177-114108360 Neighboring gene predicted gene, 30461 Neighboring gene microRNA 6941 Neighboring gene STARR-positive B cell enhancer ABC_E11526 Neighboring gene nudix hydrolase 14 Neighboring gene STARR-seq mESC enhancer starr_33372 Neighboring gene BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit Neighboring gene BTB domain containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in auditory receptor cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate determination NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within epithelial cell apoptotic process involved in palatal shelf morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gamma-delta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within respiratory system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in thymic T cell selection ISO
Inferred from Sequence Orthology
more info
 
involved_in thymic T cell selection ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein jagged-2
Names
syndactylism

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409685.1NP_001396614.1  protein jagged-2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC160929
  2. NM_010588.3NP_034718.2  protein jagged-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034718.2

    Status: VALIDATED

    Source sequence(s)
    AC160929
    Consensus CDS
    CCDS26200.1
    UniProtKB/Swiss-Prot
    F8VPV5, O55139, O70219, Q9QYE5
    Related
    ENSMUSP00000075224.4, ENSMUST00000075827.5
    Conserved Domains (5) summary
    smart00215
    Location:872943
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:827863
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:351381
    EGF; EGF-like domain
    pfam01414
    Location:178240
    DSL; Delta serrate ligand
    pfam07657
    Location:28103
    MNNL; N-terminus of Notch ligand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    112871439..112893437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)