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ITPKB inositol-trisphosphate 3-kinase B [ Homo sapiens (human) ]

Gene ID: 3707, updated on 5-Sep-2021

Summary

Official Symbol
ITPKBprovided by HGNC
Official Full Name
inositol-trisphosphate 3-kinase Bprovided by HGNC
Primary source
HGNC:HGNC:6179
See related
Ensembl:ENSG00000143772 MIM:147522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
Summary
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 10.0), fat (RPKM 9.3) and 24 other tissues See more
Orthologs
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Genomic context

See ITPKB in Genome Data Viewer
Location:
1q42.12
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (226631690..226739296, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226819391..226926983, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373116 Neighboring gene stum, mechanosensory transduction mediator homolog Neighboring gene ITPKB intronic transcript 1 Neighboring gene uncharacterized LOC105373117 Neighboring gene ribosomal protein S27 pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 12356

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in common myeloid progenitor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inositol trisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in myeloid cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neutrophil apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
inositol-trisphosphate 3-kinase B
Names
IP3 3-kinase B
IP3K B
inositol 1,4,5-trisphosphate 3-kinase B
insP 3-kinase B
proliferation-inducing protein 37
NP_001375333.1
NP_002212.3
XP_016856700.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388404.1NP_001375333.1  inositol-trisphosphate 3-kinase B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL365444
    Related
    ENSP00000355748.1, ENST00000366784.1
  2. NM_002221.4NP_002212.3  inositol-trisphosphate 3-kinase B isoform 1

    See identical proteins and their annotated locations for NP_002212.3

    Status: REVIEWED

    Source sequence(s)
    AJ242780, AK313801, AL365444, BC015009, Y18024
    Consensus CDS
    CCDS1555.1
    UniProtKB/Swiss-Prot
    P27987
    UniProtKB/TrEMBL
    B2R9J0
    Related
    ENSP00000411152.1, ENST00000429204.6
    Conserved Domains (1) summary
    pfam03770
    Location:726937
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    226631690..226739296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001211.2XP_016856700.1  inositol-trisphosphate 3-kinase B isoform X1

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