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ITPKB inositol-trisphosphate 3-kinase B [ Homo sapiens (human) ]

Gene ID: 3707, updated on 6-Jan-2019

Summary

Official Symbol
ITPKBprovided by HGNC
Official Full Name
inositol-trisphosphate 3-kinase Bprovided by HGNC
Primary source
HGNC:HGNC:6179
See related
Ensembl:ENSG00000143772 MIM:147522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
Summary
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 10.0), fat (RPKM 9.3) and 24 other tissues See more
Orthologs

Genomic context

See ITPKB in Genome Data Viewer
Location:
1q42.12
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (226631690..226739296, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226819391..226927028, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373116 Neighboring gene stum, mechanosensory transduction mediator homolog Neighboring gene ITPKB intronic transcript 1 Neighboring gene uncharacterized LOC105373117 Neighboring gene ribosomal protein S27 pseudogene 5 Neighboring gene uncharacterized LOC105373119

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
inositol-1,4,5-trisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol-1,4,5-trisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
common myeloid progenitor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
inositol trisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
myeloid cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neutrophil apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inositol-trisphosphate 3-kinase B
Names
IP3 3-kinase B
IP3K B
inositol 1,4,5-trisphosphate 3-kinase B
insP 3-kinase B
proliferation-inducing protein 37
NP_002212.3
XP_005273177.1
XP_016856700.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002221.3NP_002212.3  inositol-trisphosphate 3-kinase B

    See identical proteins and their annotated locations for NP_002212.3

    Status: REVIEWED

    Source sequence(s)
    AJ242780, AK313801, AL365444, BC015009, Y18024
    Consensus CDS
    CCDS1555.1
    UniProtKB/Swiss-Prot
    P27987
    UniProtKB/TrEMBL
    B2R9J0
    Related
    ENSP00000411152.1, ENST00000429204.5
    Conserved Domains (1) summary
    pfam03770
    Location:726937
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    226631690..226739296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273120.3XP_005273177.1  inositol-trisphosphate 3-kinase B isoform X2

    UniProtKB/Swiss-Prot
    P27987
    Related
    ENSP00000355748.1, ENST00000366784.1
    Conserved Domains (1) summary
    PRK14965
    Location:357473
    PRK14965; DNA polymerase III subunits gamma and tau; Provisional
  2. XM_017001211.2XP_016856700.1  inositol-trisphosphate 3-kinase B isoform X1

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