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ABCC6 ATP binding cassette subfamily C member 6 [ Homo sapiens (human) ]

Gene ID: 368, updated on 11-Jun-2025
Official Symbol
ABCC6provided by HGNC
Official Full Name
ATP binding cassette subfamily C member 6provided by HGNC
Primary source
HGNC:HGNC:57
See related
Ensembl:ENSG00000091262 MIM:603234; AllianceGenome:HGNC:57
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA; PXE; MLP1; MRP6; PXE1; URG7; ABC34; GACI2; MOATE; MOAT-E; EST349056
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 16.7), kidney (RPKM 9.5) and 9 other tissues See more
Orthologs
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See ABCC6 in Genome Data Viewer
Location:
16p13.11
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (16149565..16223494, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (16154422..16229003, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (16243422..16317351, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984869 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:16036240-16036407 Neighboring gene ribosomal protein L15 pseudogene 20 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:16052042-16052542 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:16052543-16053043 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:16064032-16064671 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:16064672-16065310 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:16065311-16065950 Neighboring gene ATP binding cassette subfamily C member 1 (ABCC1 blood group) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:16082729-16083392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:16084152-16084684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:16085217-16085748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:16085749-16086280 Neighboring gene Sharpr-MPRA regulatory region 4662 Neighboring gene Sharpr-MPRA regulatory region 7660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:16168601-16169318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:16169319-16170035 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:16193601-16194102 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:16194103-16194602 Neighboring gene ribosomal protein L17 pseudogene 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:16225735-16226234 Neighboring gene Sharpr-MPRA regulatory region 15590 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:16280257-16280430 Neighboring gene NANOG hESC enhancer GRCh37_chr16:16294128-16294629 Neighboring gene uncharacterized LOC105371100 Neighboring gene NODAL modulator 3 Neighboring gene Sharpr-MPRA regulatory region 11301 Neighboring gene uncharacterized LOC105371099 Neighboring gene microRNA 3179-2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in ATP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ATP transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in carboxylic acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inhibition of non-skeletal tissue mineralization IEA
Inferred from Electronic Annotation
more info
 
involved_in inorganic diphosphate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular phosphate ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in leukotriene transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphate ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphate ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to magnesium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to sodium phosphate IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus TAS
Traceable Author Statement
more info
PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
ATP-binding cassette sub-family C member 6; URG7 protein
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
anthracycline resistance-associated protein
multi-specific organic anion transporter E
multidrug resistance-associated protein 6
NP_001072996.1
NP_001162.5
NP_001338729.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007558.3 RefSeqGene

    Range
    5124..79053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1115

mRNA and Protein(s)

  1. NM_001079528.4NP_001072996.1  URG7 protein isoform 2

    See identical proteins and their annotated locations for NP_001072996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks much of the coding region and represents a distinct 3' UTR compared to variant 1. The encoded protein (isoform 2) is much shorter and has a distinct C-terminus compared to isoform 1. The encoded protein is not a transporter, but is thought to play a role in protecting hepatocytes during chronic hepatitis B virus infection.
    Source sequence(s)
    AY078405, BC050733
    Consensus CDS
    CCDS58430.1
    UniProtKB/Swiss-Prot
    O95255
    Related
    ENSP00000461686.1, ENST00000575728.1
    Conserved Domains (1) summary
    TIGR00957
    Location:1474
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  2. NM_001171.6NP_001162.5  ATP-binding cassette sub-family C member 6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC136624
    Consensus CDS
    CCDS10568.1
    UniProtKB/Swiss-Prot
    A2RRN8, A8KIG6, A8Y988, E7ESW8, O95255, P78420, Q8TCY8, Q9UMZ7
    UniProtKB/TrEMBL
    A0A0G2JMG3
    Related
    ENSP00000205557.7, ENST00000205557.12
    Conserved Domains (1) summary
    TIGR00957
    Location:141502
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  3. NM_001351800.1NP_001338729.1  ATP-binding cassette sub-family C member 6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC136624, AF076622, AI074459, BC131732
    UniProtKB/TrEMBL
    A0A0G2JMG3
    Conserved Domains (1) summary
    cl26602
    Location:11388
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
  4. NM_001440309.1NP_001427238.1  URG7 protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC136624
  5. NM_001440310.1NP_001427239.1  URG7 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC136624

RNA

  1. NR_147784.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC136624, AF076622, AI074459, AM711638
    Related
    ENST00000456970.6
  2. NR_199641.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC136624
  3. NR_199642.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC136624
  4. NR_199643.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC136624

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    16149565..16223494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1807491..1881489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    16154422..16229003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)