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PBS2 mitogen-activated protein kinase kinase [ Candida albicans SC5314 ]

Gene ID: 3641748, updated on 30-Nov-2023

Summary

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Gene symbol
PBS2
Gene description
mitogen-activated protein kinase kinase
Locus tag
CAALFM_C306070CA
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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Genomic context

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Location:
chromosome: 3
Exon count:
1
Sequence:
Chromosome: 3; NC_032091.1 (1378314..1379951, complement)

Chromosome 3 - NC_032091.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Elongator subunit Neighboring gene Rev3p Neighboring gene Och1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032091.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3. Argimón S, et al. Eukaryot Cell, 2011 Feb. PMID 21131433, Free PMC Article
  2. MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicans. Cheetham J, et al. J Biol Chem, 2011 Dec 9. PMID 21994942, Free PMC Article
  3. A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans. Cheetham J, et al. Mol Biol Cell, 2007 Nov. PMID 17804815, Free PMC Article
  4. The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans. Sellam A, et al. PLoS Genet, 2019 Mar. PMID 30921326, Free PMC Article
  5. Detection of protein-protein interactions through vesicle targeting. Boysen JH, et al. Genetics, 2009 May. PMID 19307607, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular hyperosmotic response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase
XP_716629.1
  • MAPK kinase (MAPKK); role in osmotic and oxidative stress responses, oxidative stress adaptation; required for stress regulation of Hog1p localization and activity; functional homolog of S. cerevisiae Pbs2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_032091.1 Reference assembly

    Range
    1378314..1379951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_711536.1 → XP_716629.1  mitogen-activated protein kinase kinase [Candida albicans SC5314]

    See identical proteins and their annotated locations for XP_716629.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1D8PKE2, A0A8H6C347
    Conserved Domains (2) summary
    smart00220
    Location:204 → 464
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:202 → 484
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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