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INPPL1 inositol polyphosphate phosphatase like 1 [ Homo sapiens (human) ]

Gene ID: 3636, updated on 6-Jan-2019

Summary

Official Symbol
INPPL1provided by HGNC
Official Full Name
inositol polyphosphate phosphatase like 1provided by HGNC
Primary source
HGNC:HGNC:6080
See related
Ensembl:ENSG00000165458 MIM:600829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OPSMD; SHIP2
Summary
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in placenta (RPKM 19.8), thyroid (RPKM 19.6) and 25 other tissues See more
Orthologs

Genomic context

See INPPL1 in Genome Data Viewer
Location:
11q13.4
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (72223861..72239147)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71934916..71950191)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene folate receptor 1 Neighboring gene folate receptor beta Neighboring gene skeletal muscle cis-regulatory module in INPPL1 intron Neighboring gene paired like homeobox 2A Neighboring gene dedicator of cytokinesis 1 pseudogene Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
 
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
endochondral ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Names
51C protein
INPPL-1
SH2 domain-containing inositol-5'-phosphatase 2
SHIP-2
protein 51C
NP_001558.3
XP_005274036.1
XP_011543301.1
XP_024304269.1
XP_024304270.1
XP_024304271.1
XP_024304272.1
XP_024304273.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023253.2 RefSeqGene

    Range
    5001..19310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001567.4NP_001558.3  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

    See identical proteins and their annotated locations for NP_001558.3

    Status: REVIEWED

    Source sequence(s)
    AP000593, BC140853, BG236320, Y14385
    Consensus CDS
    CCDS8213.1
    UniProtKB/Swiss-Prot
    O15357
    Related
    ENSP00000298229.2, ENST00000298229.6
    Conserved Domains (4) summary
    cd09491
    Location:11941256
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:424727
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    smart00454
    Location:12021258
    SAM; Sterile alpha motif
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    72223861..72239147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448503.1XP_024304271.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

    Conserved Domains (4) summary
    cd09491
    Location:12501312
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cl00490
    Location:436783
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    cl15255
    Location:52109
    SH2; Src homology 2 (SH2) domain
    cl26464
    Location:9551270
    Atrophin-1; Atrophin-1 family
  2. XM_024448501.1XP_024304269.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    Conserved Domains (4) summary
    cd09491
    Location:12601322
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    cl00490
    Location:446793
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    cl26464
    Location:9651280
    Atrophin-1; Atrophin-1 family
  3. XM_024448505.1XP_024304273.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X6

    Conserved Domains (3) summary
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    cl00490
    Location:446793
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    cl28033
    Location:10241242
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  4. XM_005273979.4XP_005274036.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4

    See identical proteins and their annotated locations for XP_005274036.1

    Conserved Domains (4) summary
    cd09491
    Location:12161278
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:446749
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    smart00454
    Location:12241280
    SAM; Sterile alpha motif
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  5. XM_024448504.1XP_024304272.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3

    Conserved Domains (5) summary
    cd09491
    Location:12381300
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    cl00490
    Location:424771
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    cl26464
    Location:9431258
    Atrophin-1; Atrophin-1 family
    cl27966
    Location:93181
    MinC; Septum formation inhibitor MinC [Cell cycle control, cell division, chromosome partitioning]
  6. XM_011544999.2XP_011543301.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X5

    See identical proteins and their annotated locations for XP_011543301.1

    UniProtKB/Swiss-Prot
    O15357
    Conserved Domains (4) summary
    cd09491
    Location:11941256
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:424727
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    smart00454
    Location:12021258
    SAM; Sterile alpha motif
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  7. XM_024448502.1XP_024304270.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    Conserved Domains (4) summary
    cd09491
    Location:12601322
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    cl00490
    Location:446793
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    cl26464
    Location:9651280
    Atrophin-1; Atrophin-1 family
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