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Inppl1 inositol polyphosphate phosphatase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 16332, updated on 8-Dec-2022

Summary

Official Symbol
Inppl1provided by MGI
Official Full Name
inositol polyphosphate phosphatase-like 1provided by MGI
Primary source
MGI:MGI:1333787
See related
Ensembl:ENSMUSG00000032737 AllianceGenome:MGI:1333787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
51C; SHIP2
Summary
Predicted to enable SH2 domain binding activity; inositol-polyphosphate 5-phosphatase activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Acts upstream of or within several processes, including phosphatidylinositol biosynthetic process; response to insulin; and ruffle assembly. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; ear; respiratory system; and testis. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Orthologous to human INPPL1 (inositol polyphosphate phosphatase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 43.9), heart adult (RPKM 33.8) and 26 other tissues See more
Orthologs
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Genomic context

See Inppl1 in Genome Data Viewer
Location:
7; 7 E2
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101471839..101487433, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101822632..101838226, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45995 Neighboring gene ADP-ribosyltransferase 2b Neighboring gene ClpB caseinolytic peptidase B Neighboring gene paired-like homeobox 2a Neighboring gene predicted gene 10602 Neighboring gene folate receptor 2 (fetal) Neighboring gene folate receptor 1 (adult)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-polyphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol-polyphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endochondral ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inositol trisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphatidylinositol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ruffle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Names
INPPL-1
SH2 domain-containing inositol 5'-phosphatase 2
SH2 domain-containing inositol phosphatase 2
SHIP-2
ablSH3-binding protein
inositol polyphosphate phosphatase-like protein 1
protein 51C
NP_001116211.1
NP_034697.2
XP_011239984.1
XP_030098025.1
XP_036008593.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122739.2NP_001116211.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a

    See identical proteins and their annotated locations for NP_001116211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AC159005
    Consensus CDS
    CCDS21515.1
    UniProtKB/Swiss-Prot
    Q6P549, Q9JLL7
    Related
    ENSMUSP00000132883.2, ENSMUST00000165052.8
    Conserved Domains (3) summary
    cd09491
    Location:11931255
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:425728
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  2. NM_001412588.1NP_001399517.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC159005
    UniProtKB/Swiss-Prot
    Q9JLL7
  3. NM_001412589.1NP_001399518.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC159005
    UniProtKB/Swiss-Prot
    Q9JLL7
  4. NM_001412590.1NP_001399519.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC159005
    UniProtKB/Swiss-Prot
    Q9JLL7
  5. NM_001412591.1NP_001399520.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159005
  6. NM_010567.3NP_034697.2  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a

    See identical proteins and their annotated locations for NP_034697.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AC159005
    Consensus CDS
    CCDS21515.1
    UniProtKB/Swiss-Prot
    Q6P549, Q9JLL7
    Related
    ENSMUSP00000048057.7, ENSMUST00000035836.14
    Conserved Domains (3) summary
    cd09491
    Location:11931255
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:425728
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101471839..101487433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242165.2XP_030098025.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

    Related
    ENSMUSP00000139910.2, ENSMUST00000185929.2
    Conserved Domains (2) summary
    cd09101
    Location:425728
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  2. XM_036152700.1XP_036008593.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    Conserved Domains (3) summary
    cd09491
    Location:11931255
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:425728
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  3. XM_011241682.4XP_011239984.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P549
    Conserved Domains (3) summary
    cd09491
    Location:11931255
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:425728
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:17119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

RNA

  1. XR_004934019.1 RNA Sequence

  2. XR_003946395.2 RNA Sequence