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INPP5A inositol polyphosphate-5-phosphatase A [ Homo sapiens (human) ]

Gene ID: 3632, updated on 7-Jun-2020

Summary

Official Symbol
INPP5Aprovided by HGNC
Official Full Name
inositol polyphosphate-5-phosphatase Aprovided by HGNC
Primary source
HGNC:HGNC:6076
See related
Ensembl:ENSG00000068383 MIM:600106
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5PTASE
Summary
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 7.6), testis (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See INPP5A in Genome Data Viewer
Location:
10q26.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (132537784..132783480)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134351283..134596984)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378570 Neighboring gene uncharacterized LOC105378569 Neighboring gene uncharacterized LOC107984282 Neighboring gene VISTA enhancer hs1763 Neighboring gene NK6 homeobox 2 Neighboring gene uncharacterized LOC105378571 Neighboring gene cilia and flagella associated protein 46 Neighboring gene uncharacterized LOC105378572 Neighboring gene long intergenic non-protein coding RNA 1166

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC116947, MGC116949, DKFZp434A1721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PH domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
inositol-polyphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol-polyphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol-polyphosphate 5-phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
inositol phosphate dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol phosphate dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
inositol phosphate-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
inositol polyphosphate-5-phosphatase A
Names
43 kDa inositol polyphosphate 5-phophatase
43 kDa inositol polyphosphate 5-phosphatase
CTCL tumor antigen HD-CL-02
InsP3 5-phosphatase
inositol polyphosphate-5-phosphatase, 40kD
inositol polyphosphate-5-phosphatase, 40kDa
inositol trisphosphate-5-phosphatase, 40kD
type I inositol 1,4,5-trisphosphate 5-phosphatase
type I inositol-1,4,5-trisphosphate 5-phophatase
NP_001307971.1
NP_005530.3
XP_016871693.1
XP_016871694.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321042.1NP_001307971.1  inositol polyphosphate-5-phosphatase A isoform b

    Status: REVIEWED

    Source sequence(s)
    AL392043, BC096280, BI964266, Z31695
    UniProtKB/Swiss-Prot
    Q14642
    Conserved Domains (1) summary
    cl00490
    Location:39330
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. NM_005539.5NP_005530.3  inositol polyphosphate-5-phosphatase A isoform a

    See identical proteins and their annotated locations for NP_005530.3

    Status: REVIEWED

    Source sequence(s)
    AL392043, BC096280, BI964266, HY025461, Z31695
    Consensus CDS
    CCDS7669.2
    UniProtKB/Swiss-Prot
    Q14642
    Related
    ENSP00000357583.3, ENST00000368594.8
    Conserved Domains (1) summary
    cd09092
    Location:10394
    INPP5A; Type I inositol polyphosphate 5-phosphatase I

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    132537784..132783480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016205.1XP_016871694.1  inositol polyphosphate-5-phosphatase A isoform X2

  2. XM_017016204.1XP_016871693.1  inositol polyphosphate-5-phosphatase A isoform X1

RNA

  1. XR_001747104.1 RNA Sequence

  2. XR_945735.1 RNA Sequence

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