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Inpp5a inositol polyphosphate-5-phosphatase A [ Mus musculus (house mouse) ]

Gene ID: 212111, updated on 5-Mar-2024

Summary

Official Symbol
Inpp5aprovided by MGI
Official Full Name
inositol polyphosphate-5-phosphatase Aprovided by MGI
Primary source
MGI:MGI:2686961
See related
Ensembl:ENSMUSG00000025477 AllianceGenome:MGI:2686961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables inositol-polyphosphate 5-phosphatase activity. Involved in negative regulation of neuron death. Located in dendrite. Is expressed in several structures, including craniocervical region bone; gonad; limb; nervous system; and sensory organ. Orthologous to human INPP5A (inositol polyphosphate-5-phosphatase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 45.3), cerebellum adult (RPKM 37.4) and 25 other tissues See more
Orthologs
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Genomic context

See Inpp5a in Genome Data Viewer
Location:
7 F4; 7 84.57 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138969025..139159568)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139389074..139579652)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20422 Neighboring gene predicted gene, 32571 Neighboring gene STARR-positive B cell enhancer mm9_chr7:146574741-146575042 Neighboring gene predicted gene, 46004 Neighboring gene STARR-seq mESC enhancer starr_20423 Neighboring gene predicted gene, 53346 Neighboring gene VISTA enhancer mm1683 Neighboring gene glycosylated lysosomal membrane protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_20426 Neighboring gene STARR-seq mESC enhancer starr_20427 Neighboring gene predicted gene, 33031 Neighboring gene NK6 homeobox 2 Neighboring gene cilia and flagella associated protein 46 Neighboring gene STARR-positive B cell enhancer mm9_chr7:146833912-146834213 Neighboring gene STARR-seq mESC enhancer starr_20429 Neighboring gene NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PH domain binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-polyphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol-polyphosphate 5-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables inositol-polyphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inositol polyphosphate-5-phosphatase A
Names
5PTase
type I inositol 1,4,5-trisphosphate 5-phosphatase
NP_001120835.1
NP_001342091.1
NP_898967.2
XP_017177585.1
XP_030098193.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127363.1NP_001120835.1  inositol polyphosphate-5-phosphatase A isoform a

    See identical proteins and their annotated locations for NP_001120835.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    BC056341
    Consensus CDS
    CCDS52428.1
    UniProtKB/Swiss-Prot
    E9QAS7, Q7TNC9, Q8BNK3
    Related
    ENSMUSP00000101704.2, ENSMUST00000106098.8
    Conserved Domains (1) summary
    cd09092
    Location:10394
    INPP5A; Type I inositol polyphosphate 5-phosphatase I
  2. NM_001355162.1NP_001342091.1  inositol polyphosphate-5-phosphatase A isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC112670, AC118735
    Consensus CDS
    CCDS90348.1
    UniProtKB/TrEMBL
    Q3TZT4
    Related
    ENSMUSP00000095589.3, ENSMUST00000097975.3
    Conserved Domains (1) summary
    cd09092
    Location:34402
    INPP5A; Type I inositol polyphosphate 5-phosphatase I
  3. NM_183144.3NP_898967.2  inositol polyphosphate-5-phosphatase A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift compared to variant 1. The resulting protein (isoform b) is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    BC056341
    Consensus CDS
    CCDS21954.1
    UniProtKB/TrEMBL
    E9QAS7, Q7TNC9
    Related
    ENSMUSP00000026550.8, ENSMUST00000026550.14
    Conserved Domains (1) summary
    cd09092
    Location:10394
    INPP5A; Type I inositol polyphosphate 5-phosphatase I

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    138969025..139159568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242333.2XP_030098193.1  inositol polyphosphate-5-phosphatase A isoform X2

    Conserved Domains (1) summary
    cd09092
    Location:1346
    INPP5A; Type I inositol polyphosphate 5-phosphatase I
  2. XM_017322096.2XP_017177585.1  inositol polyphosphate-5-phosphatase A isoform X1

    Conserved Domains (1) summary
    cd09092
    Location:24394
    INPP5A; Type I inositol polyphosphate 5-phosphatase I