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INPP1 inositol polyphosphate-1-phosphatase [ Homo sapiens (human) ]

Gene ID: 3628, updated on 13-Mar-2020

Summary

Official Symbol
INPP1provided by HGNC
Official Full Name
inositol polyphosphate-1-phosphataseprovided by HGNC
Primary source
HGNC:HGNC:6071
See related
Ensembl:ENSG00000151689 MIM:147263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 21.9), esophagus (RPKM 18.0) and 24 other tissues See more
Orthologs

Genomic context

See INPP1 in Genome Data Viewer
Location:
2q32.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (190343589..190371665)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (191208196..191236391)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 88 Neighboring gene uncharacterized LOC105373794 Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase Neighboring gene Sharpr-MPRA regulatory region 4599 Neighboring gene uncharacterized LOC105373802 Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene uncharacterized LOC105376748 Neighboring gene RN7SK pseudogene 179

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110984

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inositol-1,4-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
inositol phosphate dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
phosphate-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
inositol polyphosphate 1-phosphatase
Names
IPP
IPPase
NP_001122400.1
NP_002185.1
XP_005246589.1
XP_024308643.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128928.2NP_001122400.1  inositol polyphosphate 1-phosphatase

    See identical proteins and their annotated locations for NP_001122400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC092178, AI680695, AW015766, BQ100772, DA272809
    Consensus CDS
    CCDS2305.1
    UniProtKB/Swiss-Prot
    P49441
    UniProtKB/TrEMBL
    Q6IBG4
    Related
    ENSP00000376142.2, ENST00000392329.7
    Conserved Domains (1) summary
    cd01640
    Location:4387
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  2. NM_002194.4NP_002185.1  inositol polyphosphate 1-phosphatase

    See identical proteins and their annotated locations for NP_002185.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI680695, AW015766, BC106006, BQ100772, DA272809
    Consensus CDS
    CCDS2305.1
    UniProtKB/Swiss-Prot
    P49441
    UniProtKB/TrEMBL
    Q6IBG4
    Related
    ENSP00000325423.4, ENST00000322522.8
    Conserved Domains (1) summary
    cd01640
    Location:4387
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    190343589..190371665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452875.1XP_024308643.1  inositol polyphosphate 1-phosphatase isoform X1

    Conserved Domains (1) summary
    cd01640
    Location:4387
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  2. XM_005246532.1XP_005246589.1  inositol polyphosphate 1-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_005246589.1

    UniProtKB/Swiss-Prot
    P49441
    UniProtKB/TrEMBL
    Q6IBG4
    Conserved Domains (1) summary
    cd01640
    Location:4387
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
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