Inpp1 inositol polyphosphate-1-phosphatase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inpp1provided by MGI
Official Full Name: inositol polyphosphate-1-phosphataseprovided by MGI
Primary source: MGI:MGI:104848
See related: Ensembl:ENSMUSG00000026102 AllianceGenome:MGI:104848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2300002C06Rik
Summary: Predicted to enable inositol-1,4-bisphosphate 1-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation. Is expressed in several structures, including nervous system; sensory organ; and skeleton. Orthologous to human INPP1 (inositol polyphosphate-1-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 6.4), CNS E18 (RPKM 4.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 26.99 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (52824584..52856847, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (52785425..52817688, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
Title: Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U27295 (e-PCR)
- UniSTS:125706

AV137389 (e-PCR)
- UniSTS:178393

Homology

Homologs of the Inpp1 gene: The Inpp1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 443 organisms have orthologs with human gene Inpp1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,4-bisphosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol polyphosphate 1-phosphatase

Names: IPP; IPPase

NP_032410.2

EC 3.1.3.57

XP_011236743.1

EC 3.1.3.57

XP_011236744.1

EC 3.1.3.57

XP_036018134.1

EC 3.1.3.57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008384.2 → NP_032410.2 inositol polyphosphate 1-phosphatase

See identical proteins and their annotated locations for NP_032410.2

Status: VALIDATED

Source sequence(s)

AK078382, BY700907, BY713450

Consensus CDS

CCDS14947.1

UniProtKB/Swiss-Prot

P49442, Q8R3L1

Related

ENSMUSP00000027271.3, ENSMUST00000027271.9

Conserved Domains (1) summary

cd01640
Location:4 → 384

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

52824584..52856847 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162241.1 → XP_036018134.1 inositol polyphosphate 1-phosphatase isoform X1

UniProtKB/Swiss-Prot

Q8R3L1

Conserved Domains (1) summary

cd01640
Location:4 → 384

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
XM_011238441.3 → XP_011236743.1 inositol polyphosphate 1-phosphatase isoform X1

See identical proteins and their annotated locations for XP_011236743.1

UniProtKB/Swiss-Prot

P49442, Q8R3L1

Conserved Domains (1) summary

cd01640
Location:4 → 384

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
XM_011238442.4 → XP_011236744.1 inositol polyphosphate 1-phosphatase isoform X1

See identical proteins and their annotated locations for XP_011236744.1

UniProtKB/Swiss-Prot

P49442, Q8R3L1

Conserved Domains (1) summary

cd01640
Location:4 → 384

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...