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CXCL10 C-X-C motif chemokine ligand 10 [ Homo sapiens (human) ]

Gene ID: 3627, updated on 24-Nov-2020

Summary

Official Symbol
CXCL10provided by HGNC
Official Full Name
C-X-C motif chemokine ligand 10provided by HGNC
Primary source
HGNC:HGNC:10637
See related
Ensembl:ENSG00000169245 MIM:147310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
Summary
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Expression
Broad expression in appendix (RPKM 54.9), lymph node (RPKM 28.7) and 14 other tissues See more
Orthologs

Genomic context

See CXCL10 in Genome Data Viewer
Location:
4q21.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (76021118..76023497, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76942269..76944689, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene SDAD1 antisense RNA 1 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene ADP-ribosyltransferase 3 (inactive) Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene ribosomal protein L36 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Clinical samples of serum from patients infected with HIV-1 subtypes B and C exhibited upregulated levels of CXCL10 (IP10) and CCL5 (RANTES) PubMed
Clinical samples of cerebrospinal fluid from patients infected with HIV-1 subtypes B and C exhibited upregulated levels of IL7, IL10, CXCL10 (IP10), CCL2 (MCP1), and CCL3 (MIP1A) PubMed
HIV-1 infected patient clinical samples exhibit an upregulation of CXCL10 and soluble CD163, which correlates with viral load PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Curcumin, a potent and safe anti-inflammatory compound, inhibits HIV-1 gp120-mediated upregulation of the proinflammatory cytokines TNF-alpha and IL-6, and the chemokines IL-8, RANTES, and IP-10 in primary human genital epithelial cells PubMed
env Upregulation of the human proteins CCL2, CX3CL1, IL-1beta, and CXCL10 by HIV-1 gp120 involves CB2 receptor in mesencephalic neuronal/glial culture model PubMed
env HIV-1 gp120 inhibits CpG-A-induced secretion of TNF-alpha, IL-6, and IP-10 proteins in plasmacytoid dendritic cells and PBMCs PubMed
env CXCR4-tropic HIV-1 gp120 augments the expression of RANTES, IP-10, MCP-1, and LTN in peripheral blood mononuclear cells (PBMCs), while CCR5-tropic HIV-1 gp120 also induces an increase in both IP-10 and MCP-1 production PubMed
env HIV-1 gp120 inhibits TLR9-mediated upregulation of CD83 and the secretion of inflammatory cytokines TNF-alpha and IL-6, and chemokine IP10 in plasmacytoid dendritic cells (pDC) PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of chemokine (C-X-C motif) ligand 10 (CXCL10) in peptide-treated PBMCs PubMed
Nef nef Nef from the brain-derived HIV-1 isolate YU-2 remarkably upregulates IP-10 expression, which leads to neural cell death PubMed
Tat tat HIV-1 Tat upregulates CXCL10 mRNA and protein expression in CRT-MG human astroglioma cells PubMed
tat HIV-1 Tat upregulates IP-10 expression through a MAPK dependent mechanism in astrocytes and also induces IP-10 expression in immature dendritic cells, an effect that may facilitate expansion of HIV-1 infection PubMed
tat HIV-1 and the viral protein Tat modulate the expression of chemokine (C-X-C motif) ligand 10 (CXCL10; IP-10) in immature dendritic cells and monocyte-derived macrophages PubMed
tat The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes PubMed
tat HIV-1 Tat inhibits CpG-A-induced secretion of TNF-alpha, IL-6, and IP-10 proteins in plasmacytoid dendritic cells and PBMCs PubMed
tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
tat HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase PubMed
tat HIV-1 Tat increases IP-10 protein production in a time-dependent manner in both HCV-infected and uninfected human Huh7.5.1 cells PubMed
tat JAK/STAT pathway plays a major role in Tat/IFN-gamma-mediated CXCL10 induction in macrophages PubMed
tat Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor PubMed
tat HIV-1 Tat can downregulate CXCR3-mediated functions by inhibiting the chemotactic activity of IP-10/CXCL10, an effect mediated by Tat amino acids 25-31 PubMed
Vpr vpr HIV-1 Vpr upregulates the expression of CXCL10 in human monocyte-derived dendritic cells PubMed
capsid gag Infection with HIV-1 CA mutant N74D upregulates the expression of CXCL10 in primary human monocyte-derived macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CXCR3 chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase regulator activity TAS
Traceable Author Statement
more info
PubMed 
chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood circulation TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
endothelial cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
regulation of T cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endothelial tube morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
response to auditory stimulus IEA
Inferred from Electronic Annotation
more info
 
response to cold IEA
Inferred from Electronic Annotation
more info
 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-X-C motif chemokine 10
Names
10 kDa interferon gamma-induced protein
gamma IP10
interferon-inducible cytokine IP-10
protein 10 from interferon (gamma)-induced cell line
small inducible cytokine subfamily B (Cys-X-Cys), member 10
small-inducible cytokine B10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001565.4NP_001556.2  C-X-C motif chemokine 10 precursor

    See identical proteins and their annotated locations for NP_001556.2

    Status: REVIEWED

    Source sequence(s)
    AA505379, BC010954
    Consensus CDS
    CCDS43240.1
    UniProtKB/Swiss-Prot
    P02778
    UniProtKB/TrEMBL
    A0A024RDA4
    Related
    ENSP00000305651.1, ENST00000306602.3
    Conserved Domains (1) summary
    cd00273
    Location:2791
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RNA

  1. NR_168520.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112719

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    76021118..76023497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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