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INHA inhibin subunit alpha [ Homo sapiens (human) ]

Gene ID: 3623, updated on 10-Oct-2018

Summary

Official Symbol
INHAprovided by HGNC
Official Full Name
inhibin subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:6065
See related
Ensembl:ENSG00000123999 MIM:147380; Vega:OTTHUMG00000059237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]
Expression
Biased expression in testis (RPKM 55.0), adrenal (RPKM 22.2) and 2 other tissues See more
Orthologs

Genomic context

See INHA in Genome Data Viewer
Location:
2q35
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (219572232..219575713)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220436954..220440435)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198 Neighboring gene microRNA 3132 Neighboring gene obscurin like 1 Neighboring gene RNA, 7SK small nuclear pseudogene 213 Neighboring gene serine/threonine kinase 11 interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Glycoprotein hormones, organism-specific biosystem (from REACTOME)
    Glycoprotein hormones, organism-specific biosystemMore complex protein hormones have carbohydrate side chains and are called glycoprotein hormones. Hormones in this class are Follicle-stimulating hormone (FSH; follitropin), Luteinizing hormone (LH),...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
    Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
  • Peptide hormone biosynthesis, organism-specific biosystem (from REACTOME)
    Peptide hormone biosynthesis, organism-specific biosystemPeptide hormones are peptides that are secreted directly into the blood stream (endocrine hormones). They are synthesized as precursors that require proteolytic processing (not discussed here) to gen...
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity TAS
Traceable Author Statement
more info
PubMed 
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
hormone activity TAS
Traceable Author Statement
more info
PubMed 
inhibin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
erythrocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
hemoglobin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
negative regulation of follicle-stimulating hormone secretion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of interferon-gamma biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of phosphorylation TAS
Traceable Author Statement
more info
PubMed 
ovarian follicle development NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of follicle-stimulating hormone secretion TAS
Traceable Author Statement
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inhibin A complex IDA
Inferred from Direct Assay
more info
PubMed 
inhibin B complex IEA
Inferred from Electronic Annotation
more info
 
inhibin-betaglycan-ActRII complex IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inhibin alpha chain
Names
A-inhibin subunit
inhibin alpha subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002191.3NP_002182.1  inhibin alpha chain preproprotein

    See identical proteins and their annotated locations for NP_002182.1

    Status: REVIEWED

    Source sequence(s)
    AW025787, BC006391, M13981
    Consensus CDS
    CCDS2444.1
    UniProtKB/Swiss-Prot
    P05111
    Related
    ENSP00000243786.2, OTTHUMP00000065425, ENST00000243786.2, OTTHUMT00000131425
    Conserved Domains (1) summary
    smart00204
    Location:262366
    TGFB; Transforming growth factor-beta (TGF-beta) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    219572232..219575713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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