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INHA inhibin subunit alpha [ Homo sapiens (human) ]

Gene ID: 3623, updated on 19-Jul-2021

Summary

Official Symbol
INHAprovided by HGNC
Official Full Name
inhibin subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:6065
See related
Ensembl:ENSG00000123999 MIM:147380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]
Expression
Biased expression in testis (RPKM 55.0), adrenal (RPKM 22.2) and 2 other tissues See more
Orthologs
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Genomic context

See INHA in Genome Data Viewer
Location:
2q35
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (219572310..219575711)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220437032..220440433)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198 Neighboring gene obscurin like cytoskeletal adaptor 1 Neighboring gene Sharpr-MPRA regulatory region 8639 Neighboring gene RN7SK pseudogene 213 Neighboring gene serine/threonine kinase 11 interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity TAS
Traceable Author Statement
more info
PubMed 
enables growth factor activity TAS
Traceable Author Statement
more info
PubMed 
enables hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables inhibin binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in erythrocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in hemoglobin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of follicle-stimulating hormone secretion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of interferon-gamma production TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in ovarian follicle development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of follicle-stimulating hormone secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of inhibin A complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of inhibin B complex IEA
Inferred from Electronic Annotation
more info
 
part_of inhibin-betaglycan-ActRII complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inhibin alpha chain
Names
A-inhibin subunit
inhibin alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002191.4NP_002182.1  inhibin alpha chain preproprotein

    See identical proteins and their annotated locations for NP_002182.1

    Status: REVIEWED

    Source sequence(s)
    AW025787, BC006391
    Consensus CDS
    CCDS2444.1
    UniProtKB/Swiss-Prot
    P05111
    Related
    ENSP00000243786.2, ENST00000243786.3
    Conserved Domains (1) summary
    smart00204
    Location:262366
    TGFB; Transforming growth factor-beta (TGF-beta) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    219572310..219575711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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