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Ctnna3 catenin alpha 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361839, updated on 13-Apr-2024

Summary

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Symbol
Ctnna3provided by RGD
Full Name
catenin alpha 3provided by RGD
Primary source
RGD:1562230
See related
Ensembl:ENSRNOG00000000373 AllianceGenome:RGD:1562230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Catna3; RGD1559455; RGD1562230; AABR07044900.1
Summary
Predicted to enable beta-catenin binding activity. Predicted to be involved in bundle of His cell-Purkinje myocyte adhesion involved in cell communication; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell action potential. Predicted to be located in adherens junction; fascia adherens; and lamellipodium. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13. Orthologous to human CTNNA3 (catenin alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 59.4), Muscle (RPKM 29.8) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p11
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (23613016..25198699, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (23614469..25200026, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (25063124..26640428, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102552717 Neighboring gene ubiquitin-conjugating enzyme E2 S-like Neighboring gene uncharacterized LOC134483906 Neighboring gene leucine rich repeat transmembrane neuronal 3 Neighboring gene eukaryotic translation initiation factor 3, subunit G, pseudogene 1 Neighboring gene transmembrane protein 167B, pseudogene 1 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 30 Neighboring gene ubiquitin conjugating enzyme E2 V2, pseudogene 1 Neighboring gene transfer RNA alanine (anticodon AGC) 21 Neighboring gene transfer RNA serine (anticodon UGA) 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member C12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. Janssens B, et al. J Cell Sci, 2001 Sep. PMID 11590244
  2. Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. van Hengel J, et al. Eur Heart J, 2013 Jan. PMID 23136403
  3. A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs. Goossens S, et al. J Cell Sci, 2007 Jun 15. PMID 17535849
  4. Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. Gavard J, et al. J Cell Sci, 2004 Jan 15. PMID 14657280
  5. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Daneman R, et al. Proc Natl Acad Sci U S A, 2009 Jan 13. PMID 19129494, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC188744

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in fascia adherens ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
catenin alpha-3
Names
catenin (cadherin associated protein), alpha 3
rCG61001-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426985.1 → NP_001413914.1  catenin alpha-3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    23613016..25198699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099277.2 → XP_038955205.1  catenin alpha-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX81, A6JKY1
    Related
    ENSRNOP00000070169.2
    Conserved Domains (1) summary
    pfam01044
    Location:102 → 875
    Vinculin; Vinculin family

  2. XM_008772944.4 → XP_008771166.3  catenin alpha-3 isoform X2

    UniProtKB/TrEMBL
    A6JKY1
    Conserved Domains (1) summary
    pfam01044
    Location:83 → 856
    Vinculin; Vinculin family

  3. XM_017601852.3 → XP_017457341.2  catenin alpha-3 isoform X3

    UniProtKB/TrEMBL
    F1M4I1
    Related
    ENSRNOP00000054759.5
    Conserved Domains (1) summary
    pfam01044
    Location:10 → 589
    Vinculin; Vinculin family

  4. XM_039099279.2 → XP_038955207.1  catenin alpha-3 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZKV7
    Related
    ENSRNOP00000078455.1
    Conserved Domains (1) summary
    pfam01044
    Location:1 → 510
    Vinculin; Vinculin family

  5. XM_008772942.4 → XP_008771164.3  catenin alpha-3 isoform X5

    Conserved Domains (1) summary
    pfam01044
    Location:1 → 491
    Vinculin; Vinculin family

  6. XM_039099280.2 → XP_038955208.1  catenin alpha-3 isoform X6

    Conserved Domains (1) summary
    pfam01044
    Location:102 → 449
    Vinculin; Vinculin family

  7. XM_063279292.1 → XP_063135362.1  catenin alpha-3 isoform X9

  8. XM_063279290.1 → XP_063135360.1  catenin alpha-3 isoform X7

  9. XM_063279291.1 → XP_063135361.1  catenin alpha-3 isoform X8

  10. XM_063279293.1 → XP_063135363.1  catenin alpha-3 isoform X10

RNA

  1. XR_010060727.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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