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Ctnna3 catenin alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 216033, updated on 2-Nov-2024

Summary

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Official Symbol
Ctnna3provided by MGI
Official Full Name
catenin alpha 3provided by MGI
Primary source
MGI:MGI:2661445
See related
Ensembl:ENSMUSG00000060843 AllianceGenome:MGI:2661445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vr22; Catna3; 4933408A16; 4930429L08Rik
Summary
Predicted to enable actin filament binding activity and beta-catenin binding activity. Involved in cell-cell adhesion. Located in adherens junction; fascia adherens; and lamellipodium. Is expressed in cardiac muscle tissue and skin of male preputial swelling. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13. Orthologous to human CTNNA3 (catenin alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 9.1), heart adult (RPKM 3.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Ctnna3 in Genome Data Viewer
Location:
10 B4- B5.1; 10 32.57 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63265877..64841174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63430098..65003667)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2940 Neighboring gene STARR-positive B cell enhancer ABC_E1121 Neighboring gene nuclear encoded tRNA serine 3 (anticodon TGA) Neighboring gene ring finger protein 7 like Neighboring gene STARR-seq mESC enhancer starr_26935 Neighboring gene STARR-seq mESC enhancer starr_26936 Neighboring gene predicted gene, 30644 Neighboring gene STARR-seq mESC enhancer starr_26937 Neighboring gene leucine rich repeat transmembrane neuronal 3 Neighboring gene STARR-seq mESC enhancer starr_26939 Neighboring gene STARR-seq mESC enhancer starr_26940 Neighboring gene STARR-seq mESC enhancer starr_26941 Neighboring gene STARR-seq mESC enhancer starr_26942 Neighboring gene STARR-seq mESC enhancer starr_26944 Neighboring gene STARR-seq mESC enhancer starr_26945 Neighboring gene STARR-seq mESC enhancer starr_26947 Neighboring gene STARR-seq mESC enhancer starr_26948 Neighboring gene STARR-seq mESC enhancer starr_26949 Neighboring gene predicted gene, 51834 Neighboring gene predicted gene 28881

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The cardiac protein αT-catenin contributes to chemical-induced asthma. Folmsbee SS, et al. Am J Physiol Lung Cell Mol Physiol, 2015 Feb 1. PMID 25480337, Free PMC Article
  2. Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions. Weng A, et al. Biol Open, 2022 Dec 15. PMID 36420826, Free PMC Article
  3. The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation. Folmsbee SS, et al. J Allergy Clin Immunol, 2016 Jul. PMID 26947180, Free PMC Article
  4. αT-catenin in restricted brain cell types and its potential connection to autism. Folmsbee SS, et al. J Mol Psychiatry, 2016. PMID 27330745, Free PMC Article
  5. Truncated isoform of mouse alphaT-catenin is testis-restricted in expression and function. Goossens S, et al. FASEB J, 2007 Mar. PMID 17185752

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions.
    Title: Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions.
  2. SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells.
    Title: SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells.
  3. Unravelling the ultrastructural details of alphaT-catenin-deficient cell-cell contacts between heart muscle cells by the use of FIB-SEM.
    Title: Unravelling the ultrastructural details of αT-catenin-deficient cell-cell contacts between heart muscle cells by the use of FIB-SEM.
  4. alpha-catenins regulate intercalated disc maturation and actomyosin contractility, which, in turn, control Yap subcellular localization, thus providing an explanation for the loss of proliferative capacity in the newborn mammalian heart.
    Title: α-Catenin-dependent cytoskeletal tension controls Yap activity in the heart.
  5. AlphaT-catenin may contribute to asthma through a mechanism independent of inflammation and related to heart and pulmonary vein dysfunction.
    Title: The cardiac protein αT-catenin contributes to chemical-induced asthma.
  6. alphaT-catenin-null mice are viable and fertile; however, the animals exhibit progressive cardiomyopathy
    Title: Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia.
  7. study suggests a pivotal role of alphaT-catenin levels in the control of the proliferative versus invasive state of trophoblasts during placentation
    Title: Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice.
  8. By providing an extra link between the cadherin-catenin complex and intermediate filaments, the binding of alphaT-catenin to plakophilin-2 is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells.
    Title: A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart rate by cardiac conduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ventricular cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in desmosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in fascia adherens IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fascia adherens IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fascia adherens ISO
Inferred from Sequence Orthology
more info
  
located_in fascia adherens ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
catenin alpha-3
Names
alpha T-catenin
alpha-catenin-like protein
alphaT-catenin
cadherin-associated protein
catenin (cadherin associated protein), alpha 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164376.1 → NP_001157848.1  catenin alpha-3 isoform 1

    See identical proteins and their annotated locations for NP_001157848.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK142745
    Consensus CDS
    CCDS23901.1
    UniProtKB/Swiss-Prot
    Q3UQ61, Q65CL1, Q8C0N3
    UniProtKB/TrEMBL
    A4GE64
    Related
    ENSMUSP00000101080.2, ENSMUST00000105440.8
    Conserved Domains (1) summary
    pfam01044
    Location:18 → 856
    Vinculin; Vinculin family

  2. NM_001164519.1 → NP_001157991.1  catenin alpha-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC113544, AC153511, AC153513, AC153514, AC153926, AC158604, AC158638, AC158806
    UniProtKB/TrEMBL
    A4GE65
    Conserved Domains (1) summary
    pfam01044
    Location:15 → 589
    Vinculin; Vinculin family

  3. NM_177612.3 → NP_808280.2  catenin alpha-3 isoform 1

    See identical proteins and their annotated locations for NP_808280.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC153513, AK030166, AK142745
    Consensus CDS
    CCDS23901.1
    UniProtKB/Swiss-Prot
    Q3UQ61, Q65CL1, Q8C0N3
    UniProtKB/TrEMBL
    A4GE64
    Related
    ENSMUSP00000101081.2, ENSMUST00000105441.8
    Conserved Domains (1) summary
    pfam01044
    Location:18 → 856
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    63265877..64841174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513475.4 → XP_006513538.1  catenin alpha-3 isoform X1

    See identical proteins and their annotated locations for XP_006513538.1

    UniProtKB/Swiss-Prot
    Q3UQ61, Q65CL1, Q8C0N3
    UniProtKB/TrEMBL
    A4GE64
    Conserved Domains (1) summary
    pfam01044
    Location:18 → 856
    Vinculin; Vinculin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q65CL1.2 GenPept UniProtKB/Swiss-Prot:Q65CL1

Gene LinkOut

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