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Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361824, updated on 17-Aug-2024

Summary

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Symbol
Chchd10provided by RGD
Full Name
coiled-coil-helix-coiled-coil-helix domain containing 10provided by RGD
Primary source
RGD:1359417
See related
AllianceGenome:RGD:1359417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ndg2
Summary
Predicted to be involved in several processes, including mitochondria-nucleus signaling pathway; mitochondrial nucleoid organization; and positive regulation of mitochondrion organization. Predicted to be located in mitochondrial intermembrane space. Predicted to be part of MICOS complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Orthologous to human CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1781.2), Muscle (RPKM 1161.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12725274..12730295, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12725839..12727638, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13665046..13666845, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 1 like 1 Neighboring gene similar to human chromosome 22 open reading frame 15 Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene matrix metallopeptidase 11 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene uncharacterized LOC134483889 Neighboring gene derlin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. Bannwarth S, et al. Brain, 2014 Aug. PMID 24934289, Free PMC Article
  2. Loss of MICOS complex integrity and mitochondrial damage, but not TDP-43 mitochondrial localisation, are likely associated with severity of CHCHD10-related diseases. Genin EC, et al. Neurobiol Dis, 2018 Nov. PMID 30092269, Free PMC Article
  3. CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis. Genin EC, et al. EMBO Mol Med, 2016 Jan 1. PMID 26666268, Free PMC Article
  4. Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association. Martherus RS, et al. Biochem Biophys Res Commun, 2010 Nov 12. PMID 20888800
  5. Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. Kocher O, et al. J Biol Chem, 2003 Dec 26. PMID 14551195

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105647

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in maintenance of protein location in nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of synapse structure ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondria-nucleus signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial nucleoid organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cristae formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stabilization of membrane potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial
Names
Nur77 downstream gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007008.1 → NP_001007009.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

    See identical proteins and their annotated locations for NP_001007009.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082751
    UniProtKB/TrEMBL
    Q63ZY8
    Conserved Domains (1) summary
    pfam06747
    Location:98 → 131
    CHCH; CHCH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    12725274..12730295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279237.1 → XP_063135307.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  2. XM_063279234.1 → XP_063135304.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  3. XM_063279239.1 → XP_063135309.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  4. XM_063279242.1 → XP_063135312.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  5. XM_063279241.1 → XP_063135311.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  6. XM_063279244.1 → XP_063135314.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  7. XM_063279236.1 → XP_063135306.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  8. XM_063279240.1 → XP_063135310.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  9. XM_063279235.1 → XP_063135305.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  10. XM_063279243.1 → XP_063135313.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8

  11. XM_063279238.1 → XP_063135308.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q63ZY8
Nucleotide Protein Strain
Heading Accession and Version

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