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Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 103172, updated on 13-Feb-2024

Summary

Official Symbol
Chchd10provided by MGI
Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 10provided by MGI
Primary source
MGI:MGI:2143558
See related
Ensembl:ENSMUSG00000049422 AllianceGenome:MGI:2143558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndg2; 1620401E04Rik
Summary
Involved in several processes, including mitochondria-nucleus signaling pathway; positive regulation of mitochondrial transcription; and stabilization of membrane potential. Located in mitochondrion. Is expressed in several structures, including brain ventricle and choroid plexus; early embryo; hypothalamus mantle layer; renal calyx; and ventral grey horn. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Orthologous to human CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 1343.9), duodenum adult (RPKM 646.7) and 10 other tissues See more
Orthologs
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Genomic context

See Chchd10 in Genome Data Viewer
Location:
10 C1; 10 38.62 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75768964..75773584)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75933130..75937750)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene matrix metallopeptidase 11 Neighboring gene STARR-positive B cell enhancer ABC_E8863 Neighboring gene STARR-seq mESC enhancer starr_27166 Neighboring gene predicted gene 867 Neighboring gene STARR-positive B cell enhancer ABC_E11443 Neighboring gene STARR-positive B cell enhancer ABC_E5150 Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene predicted gene, 40698 Neighboring gene predicted gene 5134

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial
Names
Nur77 downstream gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175329.4NP_780538.2  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

    See identical proteins and their annotated locations for NP_780538.2

    Status: VALIDATED

    Source sequence(s)
    BC083357, BM934773, W16247
    Consensus CDS
    CCDS23938.1
    UniProtKB/TrEMBL
    Q7TNL9, Q8BW15
    Related
    ENSMUSP00000151675.2, ENSMUST00000219839.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75768964..75773584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155455.1XP_036011348.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q7TNL9, Q8BW15
    Related
    ENSMUSP00000059575.7, ENSMUST00000058906.7