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C18h18orf54 similar to human chromosome 18 open reading frame 54 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361346, updated on 17-Aug-2024

Summary

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Official Symbol
C18h18orf54provided by RGD
Official Full Name
similar to human chromosome 18 open reading frame 54provided by RGD
Primary source
RGD:1563837
See related
EnsemblRapid:ENSRNOG00000028677 AllianceGenome:RGD:1563837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Las2
Summary
Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in extracellular region. Orthologous to human C18orf54 (chromosome 18 open reading frame 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 126.6), Testes (RPKM 122.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See C18h18orf54 in Genome Data Viewer
Location:
18q12.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (66340567..66364831, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (64065125..64090260, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (68957542..68984087, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene dynactin associated protein Neighboring gene uncharacterized LOC134482986 Neighboring gene StAR-related lipid transfer domain containing 6 Neighboring gene DNA polymerase iota Neighboring gene uncharacterized LOC134483047 Neighboring gene methyl-CpG binding domain protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. Liu PY, et al. Cancer Res, 2009 Aug 1. PMID 19622765
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lung adenoma susceptibility protein 2 homolog
Names
uncharacterized protein C18orf54 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017462.2 → NP_001017462.1  lung adenoma susceptibility protein 2 homolog isoform 2 precursor

    See identical proteins and their annotated locations for NP_001017462.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q66H35
    UniProtKB/TrEMBL
    A0A8L2UIV9
    Conserved Domains (1) summary
    pfam15792
    Location:161 → 230
    LAS2; Lung adenoma susceptibility protein 2

  2. NM_001398664.1 → NP_001385593.1  lung adenoma susceptibility protein 2 homolog isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6GFU5, A0A8I6GIR2
    Related
    ENSRNOP00000087271.1, ENSRNOT00000109976.2
    Conserved Domains (1) summary
    pfam15792
    Location:161 → 232
    LAS2; Lung adenoma susceptibility protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    66340567..66364831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096987.2 → XP_038952915.1  lung adenoma susceptibility protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6GIR2
    Related
    ENSRNOP00000014670.8, ENSRNOT00000014670.9
    Conserved Domains (1) summary
    pfam15792
    Location:161 → 232
    LAS2; Lung adenoma susceptibility protein 2

  2. XM_039096989.2 → XP_038952917.1  lung adenoma susceptibility protein 2 homolog isoform X2

    Conserved Domains (1) summary
    pfam15792
    Location:44 → 115
    LAS2; Lung adenoma susceptibility protein 2

  3. XM_017601003.3 → XP_017456492.2  lung adenoma susceptibility protein 2 homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I6GIR2
    Conserved Domains (1) summary
    pfam15792
    Location:161 → 232
    LAS2; Lung adenoma susceptibility protein 2

RNA

  1. XR_596979.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H35.1 GenPept UniProtKB/Swiss-Prot:Q66H35

Gene LinkOut

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