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C18orf54 chromosome 18 open reading frame 54 [ Homo sapiens (human) ]

Gene ID: 162681, updated on 11-Jun-2021

Summary

Official Symbol
C18orf54provided by HGNC
Official Full Name
chromosome 18 open reading frame 54provided by HGNC
Primary source
HGNC:HGNC:13796
See related
Ensembl:ENSG00000166845 MIM:613258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAS2
Expression
Broad expression in testis (RPKM 6.1), placenta (RPKM 1.1) and 15 other tissues See more
Orthologs
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Genomic context

See C18orf54 in Genome Data Viewer
Location:
18q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (54357906..54382035)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (51884276..51908405)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene DNA polymerase iota Neighboring gene StAR related lipid transfer domain containing 6 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 2 Neighboring gene cupin superfamily member 1, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33382

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lung adenoma susceptibility protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288980.2NP_001275909.1  lung adenoma susceptibility protein 2 isoform a

    See identical proteins and their annotated locations for NP_001275909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB353076, AC087395, AC093462, CN359540
    Consensus CDS
    CCDS74223.1
    UniProtKB/Swiss-Prot
    Q8IYD9
    Related
    ENSP00000477654.1, ENST00000620105.5
    Conserved Domains (1) summary
    pfam15792
    Location:161235
    LAS2; Lung adenoma susceptibility protein 2
  2. NM_001288981.2NP_001275910.1  lung adenoma susceptibility protein 2 isoform a

    See identical proteins and their annotated locations for NP_001275910.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AB267906, AB353077, AC087395, AC093462, AK126503
    Consensus CDS
    CCDS74223.1
    UniProtKB/Swiss-Prot
    Q8IYD9
    Conserved Domains (1) summary
    pfam15792
    Location:161235
    LAS2; Lung adenoma susceptibility protein 2
  3. NM_001288982.2NP_001275911.1  lung adenoma susceptibility protein 2 isoform c

    See identical proteins and their annotated locations for NP_001275911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has a shorter 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AB267906, AB330144, AB353076, AC087395, AC093462, AK126503
    UniProtKB/TrEMBL
    I7HAS0
    Related
    ENSP00000497001.1, ENST00000648616.1
    Conserved Domains (1) summary
    pfam15792
    Location:161214
    LAS2; Lung adenoma susceptibility protein 2
  4. NM_001370309.1NP_001357238.1  lung adenoma susceptibility protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AB267906, AB353076, AC087395, AC093462, AK126503
    Related
    ENSP00000372368.4, ENST00000382911.8
    Conserved Domains (1) summary
    pfam15792
    Location:161235
    LAS2; Lung adenoma susceptibility protein 2
  5. NM_173529.6NP_775800.3  lung adenoma susceptibility protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_775800.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a shorter 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AB267906, AB330143, AB353076, AC087395, AC093462, AK126503
    Consensus CDS
    CCDS11956.1
    UniProtKB/Swiss-Prot
    Q8IYD9
    UniProtKB/TrEMBL
    I7GY12
    Related
    ENSP00000300091.5, ENST00000300091.5
    Conserved Domains (1) summary
    pfam15792
    Location:161233
    LAS2; Lung adenoma susceptibility protein 2

RNA

  1. NR_110234.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087395, CN359540

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    54357906..54382035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025567.2XP_016881056.1  lung adenoma susceptibility protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8IYD9
    Conserved Domains (1) summary
    pfam15792
    Location:161235
    LAS2; Lung adenoma susceptibility protein 2
  2. XM_024451093.1XP_024306861.1  lung adenoma susceptibility protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15792
    Location:161233
    LAS2; Lung adenoma susceptibility protein 2

RNA

  1. XR_001753148.1 RNA Sequence

  2. XR_001753149.1 RNA Sequence

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