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IL15RA interleukin 15 receptor subunit alpha [ Homo sapiens (human) ]

Gene ID: 3601, updated on 3-Jan-2019

Summary

Official Symbol
IL15RAprovided by HGNC
Official Full Name
interleukin 15 receptor subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:5978
See related
Ensembl:ENSG00000134470 MIM:601070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD215
Summary
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in gall bladder (RPKM 5.8), lung (RPKM 5.5) and 24 other tissues See more
Orthologs

Genomic context

See IL15RA in Genome Data Viewer
Location:
10p15.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (5948897..5978741, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5994334..6020150, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 28 Neighboring gene ankyrin repeat domain 16 Neighboring gene F-box DNA helicase 1 Neighboring gene uncharacterized LOC105376384 Neighboring gene uncharacterized LOC107984200 Neighboring gene interleukin 2 receptor subunit alpha Neighboring gene uncharacterized LOC107984201 Neighboring gene ribosomal protein L32 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of bronchodilator response in asthmatics.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IL15RA PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of interleukin 15 receptor, alpha (IL15RA) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
    Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
    Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104179

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
interleukin-15 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
interleukin-15-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-15-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endosome TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-15 receptor subunit alpha
Names
interleukin 15 receptor alpha isoform EM2
interleukin 15 receptor alpha isoform IC2
interleukin 15 receptor alpha isoform IC3
interleukin 15 receptor alpha isoform IC4
interleukin 15 receptor alpha isoform IC5
interleukin 15 receptor alpha isoform IC6
interleukin 15 receptor alpha isoform IC7
interleukin 15 receptor alpha isoform IC8
interleukin 15 receptor, alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243539.1NP_001230468.1  interleukin-15 receptor subunit alpha isoform 3

    See identical proteins and their annotated locations for NP_001230468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses a downstream, in-frame start codon, compared to variant 4. The encoded isoform (3) has a shorter N-terminus compared to isoform 4.
    Source sequence(s)
    AA847313, AF035279, AL137186, BC107777
    Consensus CDS
    CCDS58069.1
    UniProtKB/Swiss-Prot
    Q13261
    Related
    ENSP00000431529.2, ENST00000525219.6
  2. NM_001256765.1NP_001243694.1  interleukin-15 receptor subunit alpha isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AA847313, AF035279, DC298692, HQ401283
    Consensus CDS
    CCDS73065.1
    UniProtKB/Swiss-Prot
    Q13261
    UniProtKB/TrEMBL
    A0A0A0MS77, G8CVM3
    Related
    ENSP00000380421.3, ENST00000397248.6
    Conserved Domains (1) summary
    cd00033
    Location:119180
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  3. NM_001351095.1NP_001338024.1  interleukin-15 receptor subunit alpha isoform 5

    Status: REVIEWED

    Source sequence(s)
    AA847313, AK304211, AL137186, BG675498, CA308853, U31628
    Conserved Domains (1) summary
    cd00033
    Location:91152
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  4. NM_001351096.1NP_001338025.1  interleukin-15 receptor subunit alpha isoform 6

    Status: REVIEWED

    Source sequence(s)
    AF035279, AL137186, BG675498, CA308853, HQ401283
  5. NM_001351097.1NP_001338026.1  interleukin-15 receptor subunit alpha isoform 7

    Status: REVIEWED

    Source sequence(s)
    AF035279, AL137186, BC107777, CA308853
    Related
    ENSP00000380420.4, ENST00000397246.7
  6. NM_002189.4NP_002180.1  interleukin-15 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_002180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame 5' coding exon, compared to variant 4. This results in a shorter isoform (1), compared to isoform 4.
    Source sequence(s)
    AA847313, U31628
    Consensus CDS
    CCDS7074.1
    UniProtKB/Swiss-Prot
    Q13261
    Related
    ENSP00000369312.3, ENST00000379977.7
    Conserved Domains (1) summary
    cd00033
    Location:3394
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  7. NM_172200.2NP_751950.2  interleukin-15 receptor subunit alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_751950.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame coding exon, compared to variant 4. This results in a shorter isoform (2), compared to isoform 4.
    Source sequence(s)
    AA847313, AK304211, DC298692, U31628
    Consensus CDS
    CCDS7075.2
    UniProtKB/Swiss-Prot
    Q13261
    Related
    ENSP00000435454.1, ENST00000528354.5
    Conserved Domains (1) summary
    cd00033
    Location:3394
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RNA

  1. NR_046362.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon structure, compared to variant 4. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 4.
    Source sequence(s)
    AA847313, AF035279, AL137186, BC065506
    Related
    ENST00000379972.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    5948897..5978741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519471.2XP_011517773.1  interleukin-15 receptor subunit alpha isoform X12

    Conserved Domains (1) summary
    PRK14959
    Location:78188
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
  2. XM_011519474.2XP_011517776.1  interleukin-15 receptor subunit alpha isoform X15

  3. XM_011519464.2XP_011517766.1  interleukin-15 receptor subunit alpha isoform X4

    Conserved Domains (1) summary
    cd00033
    Location:91152
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  4. XM_011519463.2XP_011517765.1  interleukin-15 receptor subunit alpha isoform X3

    Conserved Domains (1) summary
    cd00033
    Location:142203
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  5. XM_011519461.2XP_011517763.1  interleukin-15 receptor subunit alpha isoform X1

    Conserved Domains (2) summary
    cd00033
    Location:142203
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam05466
    Location:212317
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
  6. XM_017016200.2XP_016871689.1  interleukin-15 receptor subunit alpha isoform X19

  7. XM_011519475.2XP_011517777.1  interleukin-15 receptor subunit alpha isoform X16

  8. XM_011519472.2XP_011517774.1  interleukin-15 receptor subunit alpha isoform X13

  9. XM_011519470.2XP_011517772.1  interleukin-15 receptor subunit alpha isoform X10

    Conserved Domains (1) summary
    cd00033
    Location:68129
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  10. XM_011519462.2XP_011517764.1  interleukin-15 receptor subunit alpha isoform X2

    Conserved Domains (2) summary
    cd00033
    Location:119180
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam05466
    Location:189294
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
  11. XM_011519467.2XP_011517769.1  interleukin-15 receptor subunit alpha isoform X7

    Conserved Domains (1) summary
    cd00033
    Location:68129
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  12. XM_017016197.2XP_016871686.1  interleukin-15 receptor subunit alpha isoform X14

  13. XM_017016196.1XP_016871685.1  interleukin-15 receptor subunit alpha isoform X14

  14. XM_011519468.1XP_011517770.1  interleukin-15 receptor subunit alpha isoform X8

    Conserved Domains (2) summary
    cd00033
    Location:142203
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam05466
    Location:212317
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
  15. XM_017016198.1XP_016871687.1  interleukin-15 receptor subunit alpha isoform X17

  16. XM_017016195.1XP_016871684.1  interleukin-15 receptor subunit alpha isoform X11

  17. XM_011519469.1XP_011517771.1  interleukin-15 receptor subunit alpha isoform X9

    Conserved Domains (1) summary
    cd00033
    Location:142203
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  18. XM_011519465.1XP_011517767.1  interleukin-15 receptor subunit alpha isoform X5

    Conserved Domains (1) summary
    cd00033
    Location:142203
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  19. XM_011519466.2XP_011517768.1  interleukin-15 receptor subunit alpha isoform X6

    Conserved Domains (2) summary
    cd00033
    Location:142203
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam05466
    Location:212317
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
  20. XM_024447983.1XP_024303751.1  interleukin-15 receptor subunit alpha isoform X22

    Related
    ENSP00000380426.3, ENST00000397255.7
  21. XM_011519477.2XP_011517779.1  interleukin-15 receptor subunit alpha isoform X24

    Related
    ENSP00000369306.1, ENST00000379971.5
  22. XM_011519476.2XP_011517778.1  interleukin-15 receptor subunit alpha isoform X23

    Related
    ENSP00000380422.2, ENST00000397250.6
  23. XM_024447981.1XP_024303749.1  interleukin-15 receptor subunit alpha isoform X20

    Conserved Domains (1) summary
    cd00033
    Location:142203
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  24. XM_017016199.1XP_016871688.1  interleukin-15 receptor subunit alpha isoform X18

  25. XM_024447982.1XP_024303750.1  interleukin-15 receptor subunit alpha isoform X21

    Conserved Domains (1) summary
    cd00033
    Location:142203
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
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