Format

Send to:

Choose Destination

ACADSB acyl-CoA dehydrogenase short/branched chain [ Homo sapiens (human) ]

Gene ID: 36, updated on 12-Oct-2019

Summary

Official Symbol
ACADSBprovided by HGNC
Official Full Name
acyl-CoA dehydrogenase short/branched chainprovided by HGNC
Primary source
HGNC:HGNC:91
See related
Ensembl:ENSG00000196177 MIM:600301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACAD7; SBCAD; 2-MEBCAD
Summary
Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic used to define members of this gene family. The ACADSB gene product has the greatest activity towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes for a mitochondrial precursor protein which is cleaved upon mitochondrial import and predicted to yield a mature peptide of approximately 43.7-KDa. [provided by RefSeq, Jul 2008]
Expression
Broad expression in liver (RPKM 72.3), kidney (RPKM 32.5) and 16 other tissues See more
Orthologs

Genomic context

See ACADSB in Genome Data Viewer
Location:
10q26.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (123009006..123058317)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124768429..124817806)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene phosphoseryl-tRNA kinase Neighboring gene IKAROS family zinc finger 5 Neighboring gene VISTA enhancer hs1319 Neighboring gene VISTA enhancer hs329

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of acyl-CoA dehydrogenase, short/branched chain (ACADSB) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
branched-chain amino acid catabolic process TAS
Traceable Author Statement
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Names
2-methyl branched chain acyl-CoA dehydrogenase
2-methylbutyryl-coenzyme A dehydrogenase
acyl-Coenzyme A dehydrogenase, short/branched chain
NP_001317103.1
NP_001600.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008003.1 RefSeqGene

    Range
    5001..54378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_451

mRNA and Protein(s)

  1. NM_001330174.2NP_001317103.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC012391, AW408417, BC032395, BQ312626, DC412570, H56072
    Consensus CDS
    CCDS81518.1
    UniProtKB/Swiss-Prot
    P45954
    Related
    ENSP00000357862.4, ENST00000368869.8
    Conserved Domains (1) summary
    cd01158
    Location:1328
    SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
  2. NM_001609.4NP_001600.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001600.1

    Status: REVIEWED

    Source sequence(s)
    AC012391, BC013756, DA964130, U12778
    Consensus CDS
    CCDS7634.1
    UniProtKB/Swiss-Prot
    P45954
    UniProtKB/TrEMBL
    A0A0S2Z3P9
    Related
    ENSP00000357873.3, ENST00000358776.6
    Conserved Domains (2) summary
    cd01158
    Location:59430
    SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
    COG1960
    Location:57428
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    123009006..123058317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center