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IL13RA1 interleukin 13 receptor subunit alpha 1 [ Homo sapiens (human) ]

Gene ID: 3597, updated on 5-Aug-2022

Summary

Official Symbol
IL13RA1provided by HGNC
Official Full Name
interleukin 13 receptor subunit alpha 1provided by HGNC
Primary source
HGNC:HGNC:5974
See related
Ensembl:ENSG00000131724 MIM:300119; AllianceGenome:HGNC:5974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NR4; CT19; CD213A1; IL-13Ra
Summary
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 22.2), liver (RPKM 22.1) and 25 other tissues See more
Orthologs
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Genomic context

See IL13RA1 in Genome Data Viewer
Location:
Xq24
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (118727606..118805228)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (117105336..117172277)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (117861569..117928496)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 11 Neighboring gene RBBP8 pseudogene 1 Neighboring gene uncharacterized LOC124905207 Neighboring gene small nucleolar RNA SNORA35 Neighboring gene TMEM30B pseudogene 1 Neighboring gene zinc finger CCHC-type containing 12 Neighboring gene long intergenic non-protein coding RNA 1285 Neighboring gene AKR7A2P pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of interleukin 13 receptor, alpha 1 gene (IL13RA1) in mammary epithelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ciliary neurotrophic factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables leukemia inhibitory factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to oncostatin-M receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leukemia inhibitory factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in oncostatin-M-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of interleukin-13 receptor complex TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-13 receptor subunit alpha-1
Names
CD213a1 antigen
IL-13 receptor subunit alpha-1
IL-13R subunit alpha-1
IL13 receptor alpha-1 chain
cancer/testis antigen 19
interleukin 13 receptor, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012841.1 RefSeqGene

    Range
    5011..71938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001560.3NP_001551.1  interleukin-13 receptor subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_001551.1

    Status: REVIEWED

    Source sequence(s)
    AL391280
    Consensus CDS
    CCDS14573.1
    UniProtKB/Swiss-Prot
    P78552, Q9UDY5
    Related
    ENSP00000360730.3, ENST00000371666.8
    Conserved Domains (2) summary
    cd00063
    Location:228336
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:131224
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    118727606..118805228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442096.1XP_047298052.1  interleukin-13 receptor subunit alpha-1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    117105336..117172277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)