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dyf-6 Intraflagellar transport protein 46 homolog [ Caenorhabditis elegans ]

Gene ID: 3565899, updated on 18-Sep-2024

Summary

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Official Symbol
dyf-6
Official Full Name
Intraflagellar transport protein 46 homolog
Primary source
WormBase:WBGene00001122
Locus tag
CELE_F46F6.4
See related
AllianceGenome:WB:WBGene00001122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in intraciliary transport and non-motile cilium assembly. Located in dendrite and neuronal cell body. Is expressed in ciliated neurons and hypodermis. Orthologous to human IFT46 (intraflagellar transport 46). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (10379693..10386508, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene UDENN domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6, daf-10 and osm-1. Bell LR, et al. Genetics, 2006 Jul. PMID 16648645, Free PMC Article
  2. Reconstitution reveals motor activation for intraflagellar transport. Mohamed MAA, et al. Nature, 2018 May. PMID 29743676, Free PMC Article
  3. Worming your way through the genome. Kuwabara PE. Trends Genet, 1997 Nov. PMID 9385843
  4. Mutations affecting the chemosensory neurons of Caenorhabditis elegans. Starich TA, et al. Genetics, 1995 Jan. PMID 7705621, Free PMC Article
  5. Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia. Yi P, et al. Curr Biol, 2017 May 22. PMID 28479320

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intraciliary transport IEA
Inferred from Electronic Annotation
more info
  
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane bounded cell projection IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Intraflagellar transport protein 46 homolog
NP_001076767.1
  • Confirmed by transcript evidence
NP_001076768.1
  • Partially confirmed by transcript evidence
NP_001076770.1
  • Confirmed by transcript evidence
NP_001379460.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10379693..10386508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083298.2 → NP_001076767.1  Intraflagellar transport protein 46 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076767.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDH6, G5EF67, Q0G838, Q1KYM3, Q1KYP5, Q20474
    Conserved Domains (1) summary
    pfam12317
    Location:254 → 439
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

  2. NM_001083301.4 → NP_001076770.1  Intraflagellar transport protein 46 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076770.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0G838
    Conserved Domains (1) summary
    pfam12317
    Location:81 → 266
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

  3. NM_001392834.1 → NP_001379460.1  Intraflagellar transport protein 46 homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam12317
    Location:103 → 288
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

  4. NM_001083299.3 → NP_001076768.1  Intraflagellar transport protein 46 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076768.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0G838
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0G838.1

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