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IL1RAP interleukin 1 receptor accessory protein [ Homo sapiens (human) ]

Gene ID: 3556, updated on 18-Jun-2019

Summary

Official Symbol
IL1RAPprovided by HGNC
Official Full Name
interleukin 1 receptor accessory proteinprovided by HGNC
Primary source
HGNC:HGNC:5995
See related
Ensembl:ENSG00000196083 MIM:602626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL1R3; C3orf13; IL-1RAcP
Summary
This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]
Expression
Broad expression in liver (RPKM 11.2), placenta (RPKM 7.8) and 21 other tissues See more
Orthologs

Genomic context

See IL1RAP in Genome Data Viewer
Location:
3q28
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (190514085..190659750)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (190231840..190378856)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene claudin 16 Neighboring gene transmembrane protein 207 Neighboring gene glucosaminyl (N-acetyl) transferase 1 pseudogene 3 Neighboring gene RN7SK pseudogene 296 Neighboring gene long intergenic non-protein coding RNA 2013 Neighboring gene chaperonin containing TCP1 subunit 6 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
NHGRI GWA Catalog
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL-1 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL-1 signaling pathway, organism-specific biosystemThe IL-1 family of cytokines currently consists of 11 members which are encoded by distinct genes and includes IL-1?, IL-1?, and the IL-1 Receptor antagonist (IL-1RA). The major role of IL-1 type cyt...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystem (from WikiPathways)
    Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystemPathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 IL-1 signaling pathway reconstructed by combining related pathways and information from the litera...
  • Th17 cell differentiation, organism-specific biosystem (from KEGG)
    Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Th17 cell differentiation, conserved biosystem (from KEGG)
    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37788

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-33 receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-2 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
interleukin-33-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-4 secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
 
synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 
trans-synaptic signaling by trans-synaptic complex IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-1 receptor accessory protein
Names
IL-1 receptor accessory protein
interleukin-1 receptor 3
interleukin-1 receptor accessory protein beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029105.2 RefSeqGene

    Range
    5001..148147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001167928.2NP_001161400.1  interleukin-1 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001161400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. It encodes the membrane-bound isoform (1).
    Source sequence(s)
    AB006537, AK291669, BG032519, BM194193, BM760155, BM973472
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    UniProtKB/TrEMBL
    A8K6K4
    Related
    ENSP00000401132.1, ENST00000439062.6
    Conserved Domains (3) summary
    pfam01582
    Location:405546
    TIR; TIR domain
    pfam13927
    Location:242335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  2. NM_001167929.2NP_001161401.1  interleukin-1 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001161401.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. It encodes the membrane-bound isoform (1).
    Source sequence(s)
    AF538733, BM194193, BM973472, DA024801
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000072516.3, ENST00000072516.7
    Conserved Domains (3) summary
    pfam01582
    Location:405546
    TIR; TIR domain
    pfam13927
    Location:242335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  3. NM_001167930.2NP_001161402.1  interleukin-1 receptor accessory protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001161402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. It encodes the soluble isoform (2).
    Source sequence(s)
    AC008249, AF538732, DA024801
    Consensus CDS
    CCDS46982.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000387371.1, ENST00000422940.5
    Conserved Domains (2) summary
    pfam13927
    Location:242335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  4. NM_001167931.2NP_001161403.1  interleukin-1 receptor accessory protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001161403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC108747, DA024801, DN990628, EF591790
    Consensus CDS
    CCDS54696.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000314807.3, ENST00000317757.7
    Conserved Domains (3) summary
    smart00255
    Location:404547
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:242335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  5. NM_001364879.1NP_001351808.1  interleukin-1 receptor accessory protein isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008249, AC108747
    Conserved Domains (3) summary
    smart00255
    Location:404547
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:242335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  6. NM_001364880.2NP_001351809.1  interleukin-1 receptor accessory protein isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008249, AC108747
    Conserved Domains (2) summary
    pfam13927
    Location:242335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  7. NM_001364881.2NP_001351810.1  interleukin-1 receptor accessory protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008249, AC108747
    Conserved Domains (3) summary
    pfam01582
    Location:405546
    TIR; TIR domain
    pfam13927
    Location:242335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  8. NM_002182.4NP_002173.1  interleukin-1 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_002173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the membrane-bound isoform (1).
    Source sequence(s)
    AB006537, BM194193, BM973472, DA024801
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000390541.1, ENST00000447382.6
    Conserved Domains (3) summary
    pfam01582
    Location:405546
    TIR; TIR domain
    pfam13927
    Location:242335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  9. NM_134470.4NP_608273.1  interleukin-1 receptor accessory protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_608273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' end of the coding region and 3' UTR, compared to variant 1. It encodes the soluble isoform (2).
    Source sequence(s)
    AC008249, AF538734, BC053621, DA024801
    Consensus CDS
    CCDS46982.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000409352.1, ENST00000422485.5
    Conserved Domains (2) summary
    pfam13927
    Location:242335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain

RNA

  1. NR_157352.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC108747, AF538730, BM973472, HY121126
  2. NR_157353.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC108747, AF538731, BM973472, HY121126

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    190514085..190659750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006348.2XP_016861837.1  interleukin-1 receptor accessory protein isoform X3

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