RBPJ recombination signal binding protein for immunoglobulin kappa J region [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBPJprovided by HGNC
Official Full Name: recombination signal binding protein for immunoglobulin kappa J regionprovided by HGNC
Primary source: HGNC:HGNC:5724
See related: Ensembl:ENSG00000168214 MIM:147183; AllianceGenome:HGNC:5724
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SUH; csl; AOS3; CBF1; KBF2; CBF-1; RBP-J; RBPJK; IGKJRB; RBP-JK; RBPSUH; IGKJRB1; RBP-J kappa
Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
Expression: Ubiquitous expression in placenta (RPKM 17.3), endometrium (RPKM 16.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p15.2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (26105449..26435131)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (26087631..26420111)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (26165080..26436753)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsa_circ_0001535 Regulates Colorectal Cancer Progression via the miR-433-3p/RBPJ Axis.
Title: Hsa_circ_0001535 Regulates Colorectal Cancer Progression via the miR-433-3p/RBPJ Axis.
Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation.
Title: Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation.
The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.
Title: The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.
Interaction between BEND5 and RBPJ suppresses breast cancer growth and metastasis via inhibiting Notch signaling.
Title: Interaction between BEND5 and RBPJ suppresses breast cancer growth and metastasis via inhibiting Notch signaling.
Colon cancer cells secreted CXCL11 via RBP-Jkappa to facilitated tumour-associated macrophage-induced cancer metastasis.
Title: Colon cancer cells secreted CXCL11 via RBP-Jκ to facilitated tumour-associated macrophage-induced cancer metastasis.
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Title: Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53.
Title: Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53.
A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions.
Title: A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions.
LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis.
Title: LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis.
Regulation of Janus Kinase 2 by an Inflammatory Bowel Disease Causal Non-coding Single Nucleotide Polymorphism.
Title: Regulation of Janus Kinase 2 by an Inflammatory Bowel Disease Causal Non-coding Single Nucleotide Polymorphism.

Submit: New GeneRIF Correction See all GeneRIFs (109)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Adams-Oliver syndrome 3 MedGen: C3553748 OMIM: 614814 GeneReviews: Adams-Oliver Syndrome	Compare labs

EBI GWAS Catalog

Description
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-67732 (e-PCR)
- UniSTS:80649

NoName (e-PCR)
- UniSTS:482339

D4S858 (e-PCR)
- UniSTS:57921

G48208 (e-PCR)
- UniSTS:95305

Rbpsuh-rs3 (e-PCR), detects polymorphism
- UniSTS:166228

D10S16 (e-PCR)
- UniSTS:155756

STS-T67414 (e-PCR)
- UniSTS:82298

SHGC-67733 (e-PCR)
- UniSTS:43905

RH35837 (e-PCR)
- UniSTS:84637

SHGC-64083 (e-PCR)
- UniSTS:928

G43168 (e-PCR)
- UniSTS:94890

SHGC-59198 (e-PCR)
- UniSTS:49588

RBPSUH_4000 (e-PCR)
- UniSTS:463309

SHGC-67311 (e-PCR)
- UniSTS:84976

NoName (e-PCR)
- UniSTS:480496

SHGC-59196 (e-PCR)
- UniSTS:66553

SHGC-133079 (e-PCR)
- UniSTS:171005

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in aortic valve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in arterial endothelial cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular canal development	ISS Inferred from Sequence or Structural Similarity more info
involved_in auditory receptor cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in blood vessel endothelial cell fate specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood vessel lumenization	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood vessel remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac left ventricle morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in club cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in dorsal aorta morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocardium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hair follicle maturation	IEA Inferred from Electronic Annotation more info
involved_in humoral immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in labyrinthine layer blood vessel development	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of ossification	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in outflow tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in pituitary gland development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERBB signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell proliferation involved in heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription of Notch receptor target	IDA Inferred from Direct Assay more info	PubMed
involved_in pulmonary valve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of reproductive process	IEA Inferred from Electronic Annotation more info
involved_in regulation of timing of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in sebaceous gland development	IEA Inferred from Electronic Annotation more info
involved_in secondary heart field specification	IEA Inferred from Electronic Annotation more info
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular trabecula myocardium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of MAML1-RBP-Jkappa- ICN1 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of MAML1-RBP-Jkappa- ICN1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: recombining binding protein suppressor of hairless

Names: H-2K binding factor-2; immunoglobulin kappa J region recombination signal binding protein 1; renal carcinoma antigen NY-REN-30; suppressor of hairless homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030343.2 RefSeqGene

Range

220567..334476

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001363577.2 → NP_001350506.1 recombining binding protein suppressor of hairless isoform 3

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS87214.1

UniProtKB/TrEMBL

A0A7P0T947

Related

ENSP00000505636.1, ENST00000681484.1

Conserved Domains (3) summary

cd01176
Location:315 → 411

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:171 → 293

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:13 → 138

LAG1-DNAbind; LAG1, DNA binding
NM_001374400.1 → NP_001361329.1 recombining binding protein suppressor of hairless isoform 1

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS3437.1

UniProtKB/Swiss-Prot

B4DY22, Q06330, Q5XKH9, Q6P1N3

UniProtKB/TrEMBL

A0A7P0T947

Related

ENSP00000423644.2, ENST00000512671.6

Conserved Domains (3) summary

cd01176
Location:350 → 446

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:206 → 328

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:48 → 173

LAG1-DNAbind; LAG1, DNA binding
NM_001374401.1 → NP_001361330.1 recombining binding protein suppressor of hairless isoform 4

Status: REVIEWED

Source sequence(s)

AC093637, AC097109, AC097714

Consensus CDS

CCDS33969.1

UniProtKB/TrEMBL

A0A7P0T947

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:192 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 159

LAG1-DNAbind; LAG1, DNA binding
NM_001374402.1 → NP_001361331.1 recombining binding protein suppressor of hairless isoform 4

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS33969.1

UniProtKB/TrEMBL

A0A7P0T947

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:192 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 159

LAG1-DNAbind; LAG1, DNA binding
NM_001374403.1 → NP_001361332.1 recombining binding protein suppressor of hairless isoform 4

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS33969.1

UniProtKB/TrEMBL

A0A7P0T947

Related

ENSP00000505493.1, ENST00000680928.1

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:192 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 159

LAG1-DNAbind; LAG1, DNA binding
NM_001379406.1 → NP_001366335.1 recombining binding protein suppressor of hairless isoform 4

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS33969.1

UniProtKB/TrEMBL

A0A7P0T947

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:192 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 159

LAG1-DNAbind; LAG1, DNA binding
NM_001379407.1 → NP_001366336.1 recombining binding protein suppressor of hairless isoform 4

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS33969.1

UniProtKB/TrEMBL

A0A7P0T947

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:192 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 159

LAG1-DNAbind; LAG1, DNA binding
NM_001379408.1 → NP_001366337.1 recombining binding protein suppressor of hairless isoform 7

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

UniProtKB/TrEMBL

D6RF98
NM_001379409.1 → NP_001366338.1 recombining binding protein suppressor of hairless isoform 6

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

UniProtKB/TrEMBL

D6RF98

Conserved Domains (3) summary

cd01176
Location:294 → 379

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:191 → 294

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:33 → 158

LAG1-DNAbind; LAG1, DNA binding
NM_005349.4 → NP_005340.2 recombining binding protein suppressor of hairless isoform 1

See identical proteins and their annotated locations for NP_005340.2

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS3437.1

UniProtKB/Swiss-Prot

B4DY22, Q06330, Q5XKH9, Q6P1N3

UniProtKB/TrEMBL

A0A7P0T947

Related

ENSP00000345206.1, ENST00000342295.6

Conserved Domains (3) summary

cd01176
Location:350 → 446

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:206 → 328

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:48 → 173

LAG1-DNAbind; LAG1, DNA binding
NM_015874.6 → NP_056958.3 recombining binding protein suppressor of hairless isoform 2

See identical proteins and their annotated locations for NP_056958.3

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS43219.1

UniProtKB/Swiss-Prot

Q06330

UniProtKB/TrEMBL

A0A7P0T947

Related

ENSP00000347659.4, ENST00000355476.8

Conserved Domains (3) summary

cd01176
Location:337 → 433

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:193 → 315

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:35 → 160

LAG1-DNAbind; LAG1, DNA binding
NM_203283.5 → NP_976028.2 recombining binding protein suppressor of hairless isoform 3

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS87214.1

UniProtKB/TrEMBL

A0A7P0T947

Related

ENSP00000305815.6, ENST00000345843.8

Conserved Domains (3) summary

cd01176
Location:315 → 411

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:171 → 293

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:13 → 138

LAG1-DNAbind; LAG1, DNA binding
NM_203284.3 → NP_976029.1 recombining binding protein suppressor of hairless isoform 4

See identical proteins and their annotated locations for NP_976029.1

Status: REVIEWED

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS33969.1

UniProtKB/Swiss-Prot

Q06330

UniProtKB/TrEMBL

A0A7P0T947

Related

ENSP00000339699.5, ENST00000348160.9

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:192 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 159

LAG1-DNAbind; LAG1, DNA binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

26105449..26435131

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047415656.1 → XP_047271612.1 recombining binding protein suppressor of hairless isoform X1

UniProtKB/TrEMBL

A0A7P0T947
XM_011513840.4 → XP_011512142.1 recombining binding protein suppressor of hairless isoform X3

See identical proteins and their annotated locations for XP_011512142.1

UniProtKB/Swiss-Prot

Q06330

UniProtKB/TrEMBL

A0A7P0T947

Related

ENSP00000426872.2, ENST00000505958.6

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:192 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 159

LAG1-DNAbind; LAG1, DNA binding
XM_047415657.1 → XP_047271613.1 recombining binding protein suppressor of hairless isoform X3

UniProtKB/TrEMBL

A0A7P0T947
XM_017008171.3 → XP_016863660.1 recombining binding protein suppressor of hairless isoform X2

UniProtKB/TrEMBL

A0A7P0T947
XM_047415658.1 → XP_047271614.1 recombining binding protein suppressor of hairless isoform X4

UniProtKB/TrEMBL

A0A7P0T947

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

26087631..26420111

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054349956.1 → XP_054205931.1 recombining binding protein suppressor of hairless isoform X1

UniProtKB/TrEMBL

A0A7P0T947
XM_054349958.1 → XP_054205933.1 recombining binding protein suppressor of hairless isoform X3

UniProtKB/TrEMBL

A0A7P0T947
XM_054349957.1 → XP_054205932.1 recombining binding protein suppressor of hairless isoform X3

UniProtKB/TrEMBL

A0A7P0T947