RBPJ recombination signal binding protein for immunoglobulin kappa J region [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBPJprovided by HGNC
Official Full Name: recombination signal binding protein for immunoglobulin kappa J regionprovided by HGNC
Primary source: HGNC:HGNC:5724
See related: Ensembl:ENSG00000168214 MIM:147183
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SUH; csl; AOS3; CBF1; KBF2; RBP-J; RBPJK; IGKJRB; RBPSUH; IGKJRB1
Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
Expression: Ubiquitous expression in placenta (RPKM 17.3), endometrium (RPKM 16.0) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 4p15.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109.20200228	current	GRCh38.p13 (GCF_000001405.39)	4	NC_000004.12 (26163458..26435131)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (26165077..26436753)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notch signaling through recombination signal binding protein for immunoglobulin kappa J region (RBPJ) controls both ovarian progesterone receptor and glucose transporter SLC2A1 expression during decidualization
Title: The Notch Family Transcription Factor, RBPJκ, Modulates Glucose Transporter and Ovarian Steroid Hormone Receptor Expression During Decidualization.
CSL controls telomere maintenance and genome stability in human dermal fibroblasts.
Title: CSL controls telomere maintenance and genome stability in human dermal fibroblasts.
CSL associates with p62/SQSTM1, which is required for CSL down-modulation by autophagy. Increasing cellular CSL levels stabilizes p62 and down-modulates the autophagic process.
Title: Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism.
SNW1 interacts with RBPJ to regulate the Notch signaling pathway in neuroblastoma
Title: SNW1 regulates Notch signaling in neuroblastoma through interacting with RBPJ.
Long non-coding RNA AFAP1-AS1/miR-320a/RBPJ axis regulates laryngeal carcinoma cell stemness and chemoresistance.
Title: Long non-coding RNA AFAP1-AS1/miR-320a/RBPJ axis regulates laryngeal carcinoma cell stemness and chemoresistance.
LANA upregulates let-7a and its primary transcripts in parallel with its reduction of RBPJ expression.
Title: Latency-associated nuclear antigen inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by regulating let-7a/RBPJ signaling.
the cyclin F-RBPJ axis has a key role in response to metabolic stress in cancer cells
Title: Cyclin F-Dependent Degradation of RBPJ Inhibits IDH1<sup>R132H</sup>-Mediated Tumorigenesis.
histone demethylase KDM6B is a direct CSL-negative target, with inverse roles of CSL in HKC and SCC proliferative capacity, tumorigenesis, and tumor-associated inflammatory reaction. CSL/KDM6B protein expression could be used as a biomarker of SCC development and indicator of cancer treatment.
Title: Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B.
Data suggest that RBP-Jkappa protein (RBPJ) and serum response factor (SRF) cooperate to regulate gene expression in aortic smooth muscle cells (SMC).
Title: RBPJ binds to consensus and methylated cis elements within phased nucleosomes and controls gene expression in human aortic smooth muscle cells in cooperation with SRF.
The DNA-binding protein CSL is the centrepiece of transcriptional regulation in the Notch pathway, acting as a molecular hub for interactions with either corepressors or coactivators to repress or activate, respectively, transcription.
Title: CSL-Associated Corepressor and Coactivator Complexes.

Submit: New GeneRIF Correction See all GeneRIFs (96)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Adams-Oliver syndrome 3 MedGen: C3553748 OMIM: 614814 GeneReviews: Adams-Oliver Syndrome	Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-67732 (e-PCR)
- UniSTS:80649

NoName (e-PCR)
- UniSTS:482339

D4S858 (e-PCR)
- UniSTS:57921

G48208 (e-PCR)
- UniSTS:95305

Rbpsuh-rs3 (e-PCR), detects polymorphism
- UniSTS:166228

D10S16 (e-PCR)
- UniSTS:155756

STS-T67414 (e-PCR)
- UniSTS:82298

SHGC-67733 (e-PCR)
- UniSTS:43905

RH35837 (e-PCR)
- UniSTS:84637

SHGC-64083 (e-PCR)
- UniSTS:928

G43168 (e-PCR)
- UniSTS:94890

SHGC-59198 (e-PCR)
- UniSTS:49588

RBPSUH_4000 (e-PCR)
- UniSTS:463309

SHGC-67311 (e-PCR)
- UniSTS:84976

NoName (e-PCR)
- UniSTS:480496

SHGC-59196 (e-PCR)
- UniSTS:66553

SHGC-133079 (e-PCR)
- UniSTS:171005

Homology

Homologs of the RBPJ gene: The RBPJ gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 302 organisms have orthologs with human gene RBPJ
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
DNA-binding transcription factor activity, RNA polymerase II-specific	ISM Inferred from Sequence Model more info	PubMed
RNA polymerase II proximal promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II repressing transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
RNA polymerase II repressing transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
chromatin binding	IEA Inferred from Electronic Annotation more info
protein N-terminus binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
repressing transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
repressing transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
B cell differentiation	IEA Inferred from Electronic Annotation more info
Clara cell differentiation	IEA Inferred from Electronic Annotation more info
Notch signaling involved in heart development	IC Inferred by Curator more info	PubMed
Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
Notch signaling pathway	TAS Traceable Author Statement more info
angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
aortic valve development	IEA Inferred from Electronic Annotation more info
arterial endothelial cell fate commitment	IEA Inferred from Electronic Annotation more info
atrioventricular canal development	ISS Inferred from Sequence or Structural Similarity more info
auditory receptor cell fate commitment	IEA Inferred from Electronic Annotation more info
blood vessel endothelial cell fate specification	ISS Inferred from Sequence or Structural Similarity more info
blood vessel lumenization	ISS Inferred from Sequence or Structural Similarity more info
blood vessel remodeling	IEA Inferred from Electronic Annotation more info
cardiac left ventricle morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
defense response to bacterium	IEA Inferred from Electronic Annotation more info
dorsal aorta morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
endocardium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
epidermal cell fate specification	IEA Inferred from Electronic Annotation more info
epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
epithelial to mesenchymal transition involved in endocardial cushion formation	ISS Inferred from Sequence or Structural Similarity more info
hair follicle maturation	IEA Inferred from Electronic Annotation more info
humoral immune response	IEA Inferred from Electronic Annotation more info
inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
interleukin-4 secretion	IEA Inferred from Electronic Annotation more info
keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
labyrinthine layer blood vessel development	ISS Inferred from Sequence or Structural Similarity more info
myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of ossification	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
outflow tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
pituitary gland development	IEA Inferred from Electronic Annotation more info
positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ERBB signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of Notch signaling pathway	TAS Traceable Author Statement more info
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	IEA Inferred from Electronic Annotation more info
positive regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cell proliferation involved in heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription of Notch receptor target	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription of Notch receptor target	TAS Traceable Author Statement more info
pulmonary valve development	IEA Inferred from Electronic Annotation more info
regulation of timing of cell differentiation	IEA Inferred from Electronic Annotation more info
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
sebaceous gland development	IEA Inferred from Electronic Annotation more info
secondary heart field specification	IEA Inferred from Electronic Annotation more info
somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
somitogenesis	IEA Inferred from Electronic Annotation more info
transcription initiation from RNA polymerase II promoter	TAS Traceable Author Statement more info
ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
ventricular trabecula myocardium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
MAML1-RBP-Jkappa- ICN1 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
MAML1-RBP-Jkappa- ICN1 complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nuclear chromatin	ISA Inferred from Sequence Alignment more info
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transcriptional repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: recombining binding protein suppressor of hairless

Names: CBF-1; H-2K binding factor-2; RBP-J kappa; RBP-JK; immunoglobulin kappa J region recombination signal binding protein 1; renal carcinoma antigen NY-REN-30; suppressor of hairless homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030343.1 RefSeqGene

Range

5001..120422

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001363577.2 → NP_001350506.1 recombining binding protein suppressor of hairless isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC093637, AC097109

Consensus CDS

CCDS87214.1

Related

ENSP00000423907.1, ENST00000507561.5

Conserved Domains (3) summary

cd01176
Location:315 → 411

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:144 → 293

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:13 → 142

LAG1-DNAbind; LAG1, DNA binding
NM_001374400.1 → NP_001361329.1 recombining binding protein suppressor of hairless isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variant 1, encodes isoform 1.

Source sequence(s)

AC093637, AC097109

Related

ENSP00000354528.6, ENST00000361572.10
NM_001374401.1 → NP_001361330.1 recombining binding protein suppressor of hairless isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 4, 8, and 9, encodes isoform 4.

Source sequence(s)

AC093637, AC097109, AC097714
NM_001374402.1 → NP_001361331.1 recombining binding protein suppressor of hairless isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variants 4, 7, and 9, encodes isoform 4.

Source sequence(s)

AC093637, AC097109

Related

ENSP00000340124.4, ENST00000342320.8
NM_001374403.1 → NP_001361332.1 recombining binding protein suppressor of hairless isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (9), as well as variants 4, 7, and 8, encodes isoform 4.

Source sequence(s)

AC093637, AC097109
NM_005349.3 → NP_005340.2 recombining binding protein suppressor of hairless isoform 1

See identical proteins and their annotated locations for NP_005340.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 6 both encode the same isoform (1).

Source sequence(s)

AC093637, AC097109, BC020780, BC064976, BM680668, L07872

Consensus CDS

CCDS3437.1

UniProtKB/Swiss-Prot

Q06330

Related

ENSP00000345206.1, ENST00000342295.5

Conserved Domains (3) summary

cd01176
Location:350 → 446

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:179 → 328

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:48 → 177

LAG1-DNAbind; LAG1, DNA binding
NM_015874.4 → NP_056958.3 recombining binding protein suppressor of hairless isoform 2

See identical proteins and their annotated locations for NP_056958.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC093637, BC064976, BM680668, DC361185

Consensus CDS

CCDS43219.1

UniProtKB/Swiss-Prot

Q06330

Related

ENSP00000339699.4, ENST00000348160.8

Conserved Domains (3) summary

cd01176
Location:337 → 433

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:166 → 315

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:35 → 164

LAG1-DNAbind; LAG1, DNA binding
NM_203283.3 → NP_976028.1 recombining binding protein suppressor of hairless isoform 3

See identical proteins and their annotated locations for NP_976028.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate 5' exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC093637, BC020780, BC064976, BM680668

Consensus CDS

CCDS3436.1

UniProtKB/Swiss-Prot

Q06330

Related

ENSP00000305815.5, ENST00000345843.7

Conserved Domains (3) summary

cd01176
Location:335 → 431

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:164 → 313

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:33 → 162

LAG1-DNAbind; LAG1, DNA binding
NM_203284.2 → NP_976029.1 recombining binding protein suppressor of hairless isoform 4

See identical proteins and their annotated locations for NP_976029.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 7, 8, and 9 all encode the same isoform (4).

Source sequence(s)

AC093637, BC020780, BC064976, BM680668, DC389691

Consensus CDS

CCDS33969.1

UniProtKB/Swiss-Prot

Q06330

Related

ENSP00000347659.3, ENST00000355476.7

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:165 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 163

LAG1-DNAbind; LAG1, DNA binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p13 Primary Assembly

Range

26163458..26435131

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008170.2 → XP_016863659.1 recombining binding protein suppressor of hairless isoform X1

Conserved Domains (3) summary

cd01176
Location:356 → 452

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:185 → 334

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:54 → 183

LAG1-DNAbind; LAG1, DNA binding
XM_024454032.1 → XP_024309800.1 recombining binding protein suppressor of hairless isoform X3

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:165 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 163

LAG1-DNAbind; LAG1, DNA binding
XM_017008175.2 → XP_016863664.1 recombining binding protein suppressor of hairless isoform X3

UniProtKB/Swiss-Prot

Q06330

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:165 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 163

LAG1-DNAbind; LAG1, DNA binding
XM_017008174.2 → XP_016863663.1 recombining binding protein suppressor of hairless isoform X3

UniProtKB/Swiss-Prot

Q06330

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:165 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 163

LAG1-DNAbind; LAG1, DNA binding
XM_011513840.3 → XP_011512142.1 recombining binding protein suppressor of hairless isoform X3

See identical proteins and their annotated locations for XP_011512142.1

UniProtKB/Swiss-Prot

Q06330

Conserved Domains (3) summary

cd01176
Location:336 → 432

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:165 → 314

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:34 → 163

LAG1-DNAbind; LAG1, DNA binding
XM_017008171.2 → XP_016863660.1 recombining binding protein suppressor of hairless isoform X2