U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG18563 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35050, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
CG18563provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032639
Locus tag
Dmel_CG18563
See related
AllianceGenome:FB:FBgn0032639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cSPH156; Dmel\CG18563; SPH156
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to human TPSAB1 (tryptase alpha/beta 1) and TPSD1 (tryptase delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
36C9-36C9; 2-53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17456670..17458044, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17456670..17458044, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46204 Neighboring gene uncharacterized protein Neighboring gene Serine protease homolog 93 Neighboring gene Bicaudal D Neighboring gene small glutamine-rich tetratricopeptide containing protein Neighboring gene cassowary

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Intermolecular Interactions Drive Protein Adaptive and Coadaptive Evolution at Both Species and Population Levels. Peng J, et al. Mol Biol Evol, 2022 Jan 7. PMID 34878126, Free PMC Article
  2. The neuropeptide Drosulfakinin regulates social isolation-induced aggression in Drosophila. Agrawal P, et al. J Exp Biol, 2020 Jan 29. PMID 31900346, Free PMC Article
  3. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article
  4. The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing. Bartok O, et al. EMBO J, 2015 Jun 3. PMID 25916830, Free PMC Article
  5. A cautionary note for retrocopy identification: DNA-based duplication of intron-containing genes significantly contributes to the origination of single exon genes. Zhang YE, et al. Bioinformatics, 2011 Jul 1. PMID 21551137, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables serine-type endopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG18563-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17456670..17458044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135997.3 → NP_609841.2  uncharacterized protein Dmel_CG18563 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609841.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q494G0, Q9VJD6
    Conserved Domains (2) summary
    smart00020
    Location:147 → 371
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:147 → 373
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJD6 Q9VJD6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools