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WDR86 WD repeat domain 86 [ Homo sapiens (human) ]

Gene ID: 349136, updated on 18-Aug-2020

Summary

Official Symbol
WDR86provided by HGNC
Official Full Name
WD repeat domain 86provided by HGNC
Primary source
HGNC:HGNC:28020
See related
Ensembl:ENSG00000187260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in spleen (RPKM 5.6), endometrium (RPKM 5.4) and 25 other tissues See more
Orthologs

Genomic context

See WDR86 in Genome Data Viewer
Location:
7q36.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (151377974..151410712, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151077536..151107775, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor 2 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Neighboring gene microRNA 671 Neighboring gene negative regulator of ubiquitin like proteins 1 Neighboring gene WDR86 antisense RNA 1 Neighboring gene microRNA 3907 Neighboring gene crystallin gamma N Neighboring gene RNA, 7SL, cytoplasmic 76, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ51355, MGC129839

General protein information

Preferred Names
WD repeat-containing protein 86

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284260.2NP_001271189.1  WD repeat-containing protein 86 isoform 1

    See identical proteins and their annotated locations for NP_001271189.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC005486, AC005996, AK296049, BC047921
    Consensus CDS
    CCDS64806.1
    UniProtKB/Swiss-Prot
    Q86TI4
    Related
    ENSP00000419162.2, ENST00000469830.2
    Conserved Domains (3) summary
    COG2319
    Location:3234
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4241
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:6195
    7WD40; WD40 repeat [structural motif]
  2. NM_001284261.2NP_001271190.1  WD repeat-containing protein 86 isoform 3

    See identical proteins and their annotated locations for NP_001271190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC005486, AC005996, AK125347, BC047921
    Consensus CDS
    CCDS64805.1
    UniProtKB/Swiss-Prot
    Q86TI4
    UniProtKB/TrEMBL
    A0A090N7X3
    Related
    ENSP00000417512.1, ENST00000477459.5
    Conserved Domains (3) summary
    COG2319
    Location:35128
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1262
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3123
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001284262.2NP_001271191.1  WD repeat-containing protein 86 isoform 4

    See identical proteins and their annotated locations for NP_001271191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC005996, BC047921, BC107125
    Consensus CDS
    CCDS75680.1
    UniProtKB/Swiss-Prot
    Q86TI4
    UniProtKB/TrEMBL
    A0A0C4DGX6
    Related
    ENSP00000482209.1, ENST00000621812.2
    Conserved Domains (2) summary
    cd00200
    Location:3215
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1262
    7WD40; WD40 repeat [structural motif]
  4. NM_198285.3NP_938026.2  WD repeat-containing protein 86 isoform 2

    See identical proteins and their annotated locations for NP_938026.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005996, BC047921, BC107125, BI757623, BX338490, BX390499, DA267732
    Consensus CDS
    CCDS5925.2
    UniProtKB/Swiss-Prot
    Q86TI4
    Related
    ENSP00000335522.6, ENST00000334493.10
    Conserved Domains (4) summary
    smart00320
    Location:543
    WD40; WD40 repeats
    COG2319
    Location:24346
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:53341
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:101135
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    151377974..151410712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516151.3XP_011514453.1  WD repeat-containing protein 86 isoform X9

    Conserved Domains (3) summary
    COG2319
    Location:3244
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4251
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1955
    7WD40; WD40 repeat [structural motif]
  2. XM_011516147.3XP_011514449.1  WD repeat-containing protein 86 isoform X5

    Conserved Domains (3) summary
    COG2319
    Location:3244
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4251
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1955
    7WD40; WD40 repeat [structural motif]
  3. XM_011516145.3XP_011514447.1  WD repeat-containing protein 86 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:3234
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4241
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:6195
    7WD40; WD40 repeat [structural motif]
  4. XM_011516144.3XP_011514446.1  WD repeat-containing protein 86 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:3234
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4241
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:6195
    7WD40; WD40 repeat [structural motif]
  5. XM_005249990.5XP_005250047.1  WD repeat-containing protein 86 isoform X7

    Conserved Domains (3) summary
    COG2319
    Location:3311
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:8301
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:6195
    7WD40; WD40 repeat [structural motif]
  6. XM_011516146.3XP_011514448.1  WD repeat-containing protein 86 isoform X4

    Conserved Domains (4) summary
    smart00320
    Location:543
    WD40; WD40 repeats
    COG2319
    Location:24346
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:53341
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:101135
    7WD40; WD40 repeat [structural motif]
  7. XM_011516148.1XP_011514450.1  WD repeat-containing protein 86 isoform X6

    See identical proteins and their annotated locations for XP_011514450.1

    Conserved Domains (3) summary
    COG2319
    Location:35113
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1262
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3113
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_005249989.4XP_005250046.1  WD repeat-containing protein 86 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:3244
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4251
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1955
    7WD40; WD40 repeat [structural motif]
  9. XM_011516150.1XP_011514452.1  WD repeat-containing protein 86 isoform X6

    See identical proteins and their annotated locations for XP_011514452.1

    Conserved Domains (3) summary
    COG2319
    Location:35113
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1262
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3113
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_006715966.3XP_006716029.1  WD repeat-containing protein 86 isoform X8

    Conserved Domains (3) summary
    COG2319
    Location:3284
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:8292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:6195
    7WD40; WD40 repeat [structural motif]
  11. XM_011516152.2XP_011514454.1  WD repeat-containing protein 86 isoform X10

    Conserved Domains (3) summary
    COG2319
    Location:3234
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4241
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:6195
    7WD40; WD40 repeat [structural motif]
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