IGFBP5 insulin like growth factor binding protein 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IGFBP5provided by HGNC
Official Full Name: insulin like growth factor binding protein 5provided by HGNC
Primary source: HGNC:HGNC:5474
See related: Ensembl:ENSG00000115461 MIM:146734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IBP5
Expression: Broad expression in ovary (RPKM 758.5), endometrium (RPKM 331.1) and 14 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 2q35

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109.20200228	current	GRCh38.p13 (GCF_000001405.39)	2	NC_000002.12 (216672105..216695549, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (217536828..217560272, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IGFBP5 is down regulated in Kidney renal papillary renal cell carcinoma kidney tissues compared to its expression in control tissues and that the expression of IGFBP5 is negatively related to patient survival
Title: Insulin-Like Growth Factor Binding Protein 5-A Probable Target of Kidney Renal Papillary Renal Cell Carcinoma.
These data lend support for the idea that unidentified cortical proteins like IGFBP5, which may not manifest a known pathologic footprint, may contribute to motor and cognitive function in older adults.
Title: Cognition may link cortical IGFBP5 levels with motor function in older adults.
Birth weight and length Z-scores were negatively associated with Z-scores of intact IGFBP-4, PAPP-A, and PAPP-A2 levels
Title: Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical cord blood and associations with birth weight and length.
In vitro analyses revealed that ROS production was induced by recombinant and adenoviral vector-mediated IGFBP-5 (AdBP5) in a dose- and time-dependent manner, regulated through MEK/ERK and JNK signaling, and primarily mediated by NADPH oxidase (Nox). Silencing IGFBP-5 in systemic sclerosis and idiopathic pulmonary fibrosis fibroblasts reduced ROS production.
Title: NADPH oxidase-mediated induction of reactive oxygen species and extracellular matrix deposition by insulin-like growth factor binding protein-5.
PKNOX2 is a tumor suppressor in gastric cancer by activation of IGFBP5 and p53 signaling pathways
Title: PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53.
The study exemplifies flow-dependent epigenetic regulation of endothelial gene expression, and also suggests that targeting the EZH2/H3K27me3/IGFBP5 pathway may offer novel therapeutics for inflammatory disorders such as atherosclerosis.
Title: Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects.
Study results demonstrated that miR-885 promoted metastasis of colorectal cancer (CRC) in vitro, and that von Willebrand factor (vWF) and IGFBP5 are potential novel target genes of miR-885, indicating that the miR-885/vWF and miR-885/IGFBP5 axes may serve roles in the metastasis of CRC.
Title: Identifying the key genes and microRNAs in colorectal cancer liver metastasis by bioinformatics analysis and in vitro experiments.
Data suggest that IGFBP5 nuclear import is mediated by KPNA5/KPNB1 complex; nuclear localization sequence of IGFBP5 is critical domain in this nuclear translocation. (IGFBP5 = insulin-like growth factor binding protein-5; KPNA5 = karyopherin subunit alpha-5; KPNB1 = karyopherin subunit beta-1/importin-beta)
Title: Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.
These results suggest that the C-terminus of IGFBP-5 exerts anti-cancer activity by inhibiting angiogenesis via regulation of the Akt/ERK and NF-kB-VEGF/MMP-9 signaling pathway.
Title: The C-terminus of IGFBP-5 suppresses tumor growth by inhibiting angiogenesis.
AMP-IBP5 markedly enhanced keratinocyte migration and proliferation. AMP-IBP5-induced keratinocyte activation was mediated by Mrg X1-X4 receptors with MAPK and NF-kappaB pathways.
Title: The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:471316

SGC31996 (e-PCR)
- UniSTS:80917

RH75182 (e-PCR)
- UniSTS:85051

IGFBP5_747 (e-PCR)
- UniSTS:277359

IGFBP5_V100 (e-PCR)
- UniSTS:277359

L27559 (e-PCR)
- UniSTS:69500

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:143490

D2S1600E (e-PCR)
- UniSTS:150683

STS-T65427 (e-PCR)
- UniSTS:28075

WI-20588 (e-PCR)
- UniSTS:28076

D2S2725 (e-PCR)
- UniSTS:36305

G60184 (e-PCR)
- UniSTS:137443

D2S2836 (e-PCR)
- UniSTS:42735

Homology

Homologs of the IGFBP5 gene: The IGFBP5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 272 organisms have orthologs with human gene IGFBP5
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor I binding	IPI Inferred from Physical Interaction more info	PubMed
insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
aging	IEA Inferred from Electronic Annotation more info
cellular protein metabolic process	TAS Traceable Author Statement more info
cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
female pregnancy	IEA Inferred from Electronic Annotation more info
glucose homeostasis	IEA Inferred from Electronic Annotation more info
hair follicle morphogenesis	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
lung alveolus development	IEA Inferred from Electronic Annotation more info
mammary gland involution	IEA Inferred from Electronic Annotation more info
negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of growth	IEA Inferred from Electronic Annotation more info
negative regulation of insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of muscle tissue development	IEA Inferred from Electronic Annotation more info
negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of skeletal muscle hypertrophy	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
osteoblast differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of protein kinase B signaling	IEA Inferred from Electronic Annotation more info
positive regulation of vascular associated smooth muscle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of vascular smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
post-translational protein modification	TAS Traceable Author Statement more info
regulation of cell growth	IEA Inferred from Electronic Annotation more info
regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to growth hormone	ISS Inferred from Sequence or Structural Similarity more info
signal transduction	NAS Non-traceable Author Statement more info	PubMed
striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info
type B pancreatic cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endoplasmic reticulum lumen	TAS Traceable Author Statement more info
extracellular region	NAS Non-traceable Author Statement more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor binding protein complex	IC Inferred by Curator more info	PubMed
insulin-like growth factor ternary complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor-binding protein 5

Names: IBP-5; IGF-binding protein 5; IGFBP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000599.4 → NP_000590.1 insulin-like growth factor-binding protein 5 precursor

See identical proteins and their annotated locations for NP_000590.1

Status: VALIDATED

Source sequence(s)

AC007563

Consensus CDS

CCDS2405.1

UniProtKB/Swiss-Prot

P24593

UniProtKB/TrEMBL

A0A024R433

Related

ENSP00000233813.4, ENST00000233813.5

Conserved Domains (2) summary

smart00121
Location:25 → 101

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:192 → 263

Thyroglobulin_1; Thyroglobulin type-1 repeat