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IGFBP5 insulin like growth factor binding protein 5 [ Homo sapiens (human) ]

Gene ID: 3488, updated on 12-Oct-2019

Summary

Official Symbol
IGFBP5provided by HGNC
Official Full Name
insulin like growth factor binding protein 5provided by HGNC
Primary source
HGNC:HGNC:5474
See related
Ensembl:ENSG00000115461 MIM:146734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP5
Expression
Broad expression in ovary (RPKM 758.5), endometrium (RPKM 331.1) and 14 other tissues See more
Orthologs

Genomic context

See IGFBP5 in Genome Data Viewer
Location:
2q35
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (216672105..216695549, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217536828..217560272, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene proteasome subunit beta 3 pseudogene 2 Neighboring gene insulin like growth factor binding protein 2 Neighboring gene uncharacterized LOC101928278 Neighboring gene ribosomal protein L31 pseudogene 14 Neighboring gene RNA, 5S ribosomal pseudogene 120

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
NHGRI GWA Catalog
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor I binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
mammary gland involution IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of skeletal muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular associated smooth muscle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to growth hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor binding protein complex IC
Inferred by Curator
more info
PubMed 
insulin-like growth factor ternary complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor-binding protein 5
Names
IBP-5
IGF-binding protein 5
IGFBP-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000599.4NP_000590.1  insulin-like growth factor-binding protein 5 precursor

    See identical proteins and their annotated locations for NP_000590.1

    Status: VALIDATED

    Source sequence(s)
    AC007563
    Consensus CDS
    CCDS2405.1
    UniProtKB/Swiss-Prot
    P24593
    UniProtKB/TrEMBL
    A0A024R433
    Related
    ENSP00000233813.4, ENST00000233813.5
    Conserved Domains (2) summary
    smart00121
    Location:25101
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:192263
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    216672105..216695549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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