IGFBP5 insulin like growth factor binding protein 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IGFBP5provided by HGNC
Official Full Name: insulin like growth factor binding protein 5provided by HGNC
Primary source: HGNC:HGNC:5474
See related: Ensembl:ENSG00000115461 MIM:146734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IBP5
Expression: Broad expression in ovary (RPKM 758.5), endometrium (RPKM 331.1) and 14 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 2q35

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	2	NC_000002.12 (216672105..216695549, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (217536828..217560272, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Data suggest that IGFBP5 nuclear import is mediated by KPNA5/KPNB1 complex; nuclear localization sequence of IGFBP5 is critical domain in this nuclear translocation. (IGFBP5 = insulin-like growth factor binding protein-5; KPNA5 = karyopherin subunit alpha-5; KPNB1 = karyopherin subunit beta-1/importin-beta)
Title: Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.
These results suggest that the C-terminus of IGFBP-5 exerts anti-cancer activity by inhibiting angiogenesis via regulation of the Akt/ERK and NF-kB-VEGF/MMP-9 signaling pathway.
Title: The C-terminus of IGFBP-5 suppresses tumor growth by inhibiting angiogenesis.
AMP-IBP5 markedly enhanced keratinocyte migration and proliferation. AMP-IBP5-induced keratinocyte activation was mediated by Mrg X1-X4 receptors with MAPK and NF-kappaB pathways.
Title: The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors.
Factor Xa induced endothelial cell senescence through IGFBP-5.
Title: Activated Factor X Induces Endothelial Cell Senescence Through IGFBP-5.
Co-ordinated and reciprocal alteration in IGFBP-2 and -5 expression may play a role in the acquisition of endocrine resistance in breast cancer.
Title: Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro.
The findings suggest that miR-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 and IGFBP5.
Title: microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5.
MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling.
Title: MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling.
dysregulation of DNMT3A and IGFBP5 is relevant to preeclampsia. Thus, we propose that DNMT3A and IGFBP5 can serve as potential markers and targets for the clinical diagnosis and therapy of preeclampsia.
Title: Dysregulated DNA Methyltransferase 3A Upregulates IGFBP5 to Suppress Trophoblast Cell Migration and Invasion in Preeclampsia.
IGFBP5 promoter and exon-I methylation did not have any differences between tumor and adjacent tissues so that IGFBP5 methylation did not change IGFBP5 gene regulation in breast cancer.
Title: Correlation between the DNA methylation and gene expression of IGFBP5 in breast cancer.
IGFBP5 promoted osteogenic differentiation potentials of periodontal ligament stem cells and Wharton's jelly umbilical cord stem cells via the JNK and MEK/Erk signalling pathways.
Title: IGFBP5 enhances osteogenic differentiation potential of periodontal ligament stem cells and Wharton's jelly umbilical cord stem cells, via the JNK and MEK/Erk signalling pathways.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystem (from WikiPathways)
Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystemThe signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem (from REACTOME)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystemThe family of Insulin like Growth Factor Binding Proteins (IGFBPs) share 50% amino acid identity with conserved N terminal and C terminal regions responsible for binding Insulin like Growth Factors I...
Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:471316

SGC31996 (e-PCR)
- UniSTS:80917

RH75182 (e-PCR)
- UniSTS:85051

IGFBP5_747 (e-PCR)
- UniSTS:277359

IGFBP5_V100 (e-PCR)
- UniSTS:277359

L27559 (e-PCR)
- UniSTS:69500

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:143490

D2S1600E (e-PCR)
- UniSTS:150683

STS-T65427 (e-PCR)
- UniSTS:28075

WI-20588 (e-PCR)
- UniSTS:28076

D2S2725 (e-PCR)
- UniSTS:36305

G60184 (e-PCR)
- UniSTS:137443

D2S2836 (e-PCR)
- UniSTS:42735

Homology

Homologs of the IGFBP5 gene: The IGFBP5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 219 organisms have orthologs with human gene IGFBP5
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor I binding	IPI Inferred from Physical Interaction more info	PubMed
insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
aging	IEA Inferred from Electronic Annotation more info
cellular protein metabolic process	TAS Traceable Author Statement more info
cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
female pregnancy	IEA Inferred from Electronic Annotation more info
glucose homeostasis	IEA Inferred from Electronic Annotation more info
glucose metabolic process	IEA Inferred from Electronic Annotation more info
hair follicle morphogenesis	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
lung alveolus development	IEA Inferred from Electronic Annotation more info
mammary gland involution	IEA Inferred from Electronic Annotation more info
negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of growth	IEA Inferred from Electronic Annotation more info
negative regulation of insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of muscle tissue development	IEA Inferred from Electronic Annotation more info
negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of skeletal muscle hypertrophy	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
osteoblast differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of protein kinase B signaling	IEA Inferred from Electronic Annotation more info
positive regulation of vascular associated smooth muscle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of vascular smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
post-translational protein modification	TAS Traceable Author Statement more info
regulation of cell growth	IEA Inferred from Electronic Annotation more info
regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to growth hormone	ISS Inferred from Sequence or Structural Similarity more info
signal transduction	NAS Non-traceable Author Statement more info	PubMed
striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info
type B pancreatic cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endoplasmic reticulum lumen	TAS Traceable Author Statement more info
extracellular region	NAS Non-traceable Author Statement more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor binding protein complex	IC Inferred by Curator more info	PubMed
insulin-like growth factor ternary complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor-binding protein 5

Names: IBP-5; IGF-binding protein 5; IGFBP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000599.4 → NP_000590.1 insulin-like growth factor-binding protein 5 precursor

See identical proteins and their annotated locations for NP_000590.1

Status: VALIDATED

Source sequence(s)

AC007563

Consensus CDS

CCDS2405.1

UniProtKB/Swiss-Prot

P24593

UniProtKB/TrEMBL

A0A024R433

Related

ENSP00000233813.4, ENST00000233813.4

Conserved Domains (2) summary

smart00121
Location:25 → 101

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:192 → 263

Thyroglobulin_1; Thyroglobulin type-1 repeat