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IGFBP5 insulin like growth factor binding protein 5 [ Homo sapiens (human) ]

Gene ID: 3488, updated on 11-Jun-2025
Official Symbol
IGFBP5provided by HGNC
Official Full Name
insulin like growth factor binding protein 5provided by HGNC
Primary source
HGNC:HGNC:5474
See related
Ensembl:ENSG00000115461 MIM:146734; AllianceGenome:HGNC:5474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP5
Summary
Enables insulin-like growth factor I binding activity and receptor ligand activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex. Biomarker of pulmonary fibrosis. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in ovary (RPKM 758.5), endometrium (RPKM 331.1) and 14 other tissues See more
Orthologs
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See IGFBP5 in Genome Data Viewer
Location:
2q35
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216672105..216695549, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (217154530..217177979, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217536828..217560272, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:217485350-217485850 Neighboring gene uncharacterized LOC124907977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217508368-217508942 Neighboring gene insulin like growth factor binding protein 2 Neighboring gene uncharacterized LOC124900515 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12306 Neighboring gene IGFBP5 antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 14 Neighboring gene RNA, 5S ribosomal pseudogene 120

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
EBI GWAS Catalog
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fibronectin binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin-like growth factor I binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor I binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mammary gland involution IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of skeletal muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to growth hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IC
Inferred by Curator
more info
PubMed 
part_of insulin-like growth factor binding protein complex IC
Inferred by Curator
more info
PubMed 
part_of insulin-like growth factor ternary complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of insulin-like growth factor ternary complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
insulin-like growth factor-binding protein 5
Names
IBP-5
IGF-binding protein 5
IGFBP-5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000599.4NP_000590.1  insulin-like growth factor-binding protein 5 precursor

    See identical proteins and their annotated locations for NP_000590.1

    Status: VALIDATED

    Source sequence(s)
    AC007563
    Consensus CDS
    CCDS2405.1
    UniProtKB/Swiss-Prot
    P24593, Q5U0A3
    Related
    ENSP00000233813.4, ENST00000233813.5
    Conserved Domains (2) summary
    smart00121
    Location:25101
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:192263
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    216672105..216695549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    217154530..217177979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)