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Igfbp5 insulin-like growth factor binding protein 5 [ Mus musculus (house mouse) ]

Gene ID: 16011, updated on 27-Nov-2022

Summary

Official Symbol
Igfbp5provided by MGI
Official Full Name
insulin-like growth factor binding protein 5provided by MGI
Primary source
MGI:MGI:96440
See related
Ensembl:ENSMUSG00000026185 AllianceGenome:MGI:96440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IGFBP-5; IGFBP-5P
Summary
Enables fibronectin binding activity and insulin-like growth factor binding activity. Involved in several processes, including female pregnancy; lung alveolus development; and negative regulation of skeletal muscle hypertrophy. Acts upstream of or within several processes, including hair follicle morphogenesis; negative regulation of osteoblast differentiation; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; embryo ectoderm; impulse conducting system; limb; and metanephros. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 121.4), kidney adult (RPKM 105.9) and 20 other tissues See more
Orthologs
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Genomic context

See Igfbp5 in Genome Data Viewer
Location:
1 C3; 1 36.94 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72897224..72914024, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72858065..72874865, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30788 Neighboring gene predicted gene, 30847 Neighboring gene predicted gene, 53254 Neighboring gene insulin-like growth factor binding protein 2 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 31047

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor I binding TAS
Traceable Author Statement
more info
PubMed 
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland involution IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of skeletal muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of insulin-like growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within type B pancreatic cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of insulin-like growth factor binding protein complex IC
Inferred by Curator
more info
PubMed 
part_of insulin-like growth factor ternary complex ISO
Inferred from Sequence Orthology
more info
 
part_of insulin-like growth factor ternary complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor-binding protein 5
Names
IBP-5
IGF-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010518.2NP_034648.2  insulin-like growth factor-binding protein 5 precursor

    See identical proteins and their annotated locations for NP_034648.2

    Status: VALIDATED

    Source sequence(s)
    BC018579, BC029321, BC057447
    Consensus CDS
    CCDS15037.1
    UniProtKB/Swiss-Prot
    Q07079
    UniProtKB/TrEMBL
    A0A6P5PU58, Q3UQV0
    Related
    ENSMUSP00000027377.9, ENSMUST00000027377.9
    Conserved Domains (2) summary
    smart00121
    Location:24100
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:191262
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    72897224..72914024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)