Format

Send to:

Choose Destination

SLC35B2 solute carrier family 35 member B2 [ Homo sapiens (human) ]

Gene ID: 347734, updated on 8-Jul-2021

Summary

Official Symbol
SLC35B2provided by HGNC
Official Full Name
solute carrier family 35 member B2provided by HGNC
Primary source
HGNC:HGNC:16872
See related
Ensembl:ENSG00000157593 MIM:610788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLL; PAPST1; UGTrel4
Summary
Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in gall bladder (RPKM 17.2), thyroid (RPKM 15.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SLC35B2 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (44254101..44257890, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44221838..44225627, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA polymerase I and III subunit C Neighboring gene solute carrier family 29 member 1 (Augustine blood group) Neighboring gene heat shock protein 90 alpha family class B member 1 Neighboring gene microRNA 4647 Neighboring gene transmembrane protein 151B Neighboring gene NFKB inhibitor epsilon Neighboring gene t-complex-associated-testis-expressed 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenosine 3'-phospho 5'-phosphosulfate transporter 1
Names
3'-phosphoadenosine 5'-phosphosulfate transporter
PAPS transporter 1
putative MAPK-activating protein PM15
putative NF-kappa-B-activating protein 48
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
solute carrier family 35 member B2 variant 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286509.2NP_001273438.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b

    See identical proteins and their annotated locations for NP_001273438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshifted 5' coding region and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AB106538, AK075456, AK223028, CN370928, HY044970
    UniProtKB/Swiss-Prot
    Q8TB61
    Conserved Domains (1) summary
    pfam08449
    Location:106407
    UAA; UAA transporter family
  2. NM_001286510.2NP_001273439.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b

    See identical proteins and their annotated locations for NP_001273439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and uses an alternate splice site that results in a frameshifted 5' coding region and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK075456, AK223028, AK307572, DB010939
    UniProtKB/Swiss-Prot
    Q8TB61
    Conserved Domains (1) summary
    pfam08449
    Location:106407
    UAA; UAA transporter family
  3. NM_001286511.2NP_001273440.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c

    See identical proteins and their annotated locations for NP_001273440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
    Source sequence(s)
    AB106538, AK075456, AK223028, DA817588
    Consensus CDS
    CCDS75463.1
    UniProtKB/Swiss-Prot
    Q8TB61
    Related
    ENSP00000480681.1, ENST00000615337.4
    Conserved Domains (1) summary
    pfam08449
    Location:62363
    UAA; UAA transporter family
  4. NM_001286512.2NP_001273441.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c

    See identical proteins and their annotated locations for NP_001273441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' exon and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
    Source sequence(s)
    AK075456, AK223028, AK307572, AY491520
    Consensus CDS
    CCDS75463.1
    UniProtKB/Swiss-Prot
    Q8TB61
    Related
    ENSP00000483181.1, ENST00000619636.4
    Conserved Domains (1) summary
    pfam08449
    Location:62363
    UAA; UAA transporter family
  5. NM_001286513.2NP_001273442.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform d precursor

    See identical proteins and their annotated locations for NP_001273442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon, resulting in a frameshifted 5' coding region and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK075456, AK223028, AK293344
    Consensus CDS
    CCDS69127.1
    UniProtKB/Swiss-Prot
    Q8TB61
    Related
    ENSP00000443845.1, ENST00000538577.5
    Conserved Domains (1) summary
    pfam08449
    Location:28319
    UAA; UAA transporter family
  6. NM_001286517.2NP_001273446.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform e

    See identical proteins and their annotated locations for NP_001273446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon, resulting in translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB106538, AK075456, AK223028, BI769501, HY044970
    UniProtKB/Swiss-Prot
    Q8TB61
    Related
    ENST00000495706.1
    Conserved Domains (1) summary
    pfam08449
    Location:6307
    UAA; UAA transporter family
  7. NM_001286519.2NP_001273448.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f

    See identical proteins and their annotated locations for NP_001273448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate exons, resulting in translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (f) is shorter at the N-terminus, compared to isoform a. Both variants 8 and 9 encode isoform f.
    Source sequence(s)
    AK075456, AK223028, AK293251, HY044970
    Consensus CDS
    CCDS75462.1
    UniProtKB/Swiss-Prot
    Q8TB61
    Related
    ENSP00000440340.1, ENST00000537814.2
    Conserved Domains (1) summary
    pfam08449
    Location:20279
    UAA; UAA transporter family
  8. NM_001286520.2NP_001273449.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f

    See identical proteins and their annotated locations for NP_001273449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice site that results in translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (f) is shorter at the N-terminus, compared to isoform a. Both variants 8 and 9 encode isoform f.
    Source sequence(s)
    AB106538, AK075456, AK223028, DA424392
    Consensus CDS
    CCDS75462.1
    UniProtKB/Swiss-Prot
    Q8TB61
    Conserved Domains (1) summary
    pfam08449
    Location:20279
    UAA; UAA transporter family
  9. NM_178148.4NP_835361.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform a precursor

    See identical proteins and their annotated locations for NP_835361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AB106538, AK075456, AK223028, HY044970
    Consensus CDS
    CCDS34462.1
    UniProtKB/Swiss-Prot
    Q8TB61
    Related
    ENSP00000377401.3, ENST00000393812.4
    Conserved Domains (1) summary
    pfam08449
    Location:111412
    UAA; UAA transporter family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    44254101..44257890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center