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LRRTM3 leucine rich repeat transmembrane neuronal 3 [ Homo sapiens (human) ]

Gene ID: 347731, updated on 1-Aug-2020

Summary

Official Symbol
LRRTM3provided by HGNC
Official Full Name
leucine rich repeat transmembrane neuronal 3provided by HGNC
Primary source
HGNC:HGNC:19410
See related
Ensembl:ENSG00000198739 MIM:610869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 4.5), adrenal (RPKM 1.0) and 2 other tissues See more
Orthologs

Genomic context

See LRRTM3 in Genome Data Viewer
Location:
10q21.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (66926036..67101551)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (68685792..68861309)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378339 Neighboring gene catenin alpha 3 Neighboring gene uncharacterized LOC105378340 Neighboring gene uncharacterized LOC101928961 Neighboring gene ribosomal protein L7a pseudogene 51 Neighboring gene microRNA 7151

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131810

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat transmembrane neuronal protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178011.5NP_821079.3  leucine-rich repeat transmembrane neuronal protein 3 precursor

    See identical proteins and their annotated locations for NP_821079.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC022401, AC069536, BC111492
    Consensus CDS
    CCDS7270.1
    UniProtKB/Swiss-Prot
    Q86VH5
    Related
    ENSP00000355187.3, ENST00000361320.5
    Conserved Domains (3) summary
    smart00013
    Location:3361
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:82290
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:6686
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. NR_111909.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and contains two alternate 5' exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC022401, BU154601, DB029785

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    66926036..67101551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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