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Lrrtm3 leucine rich repeat transmembrane neuronal 3 [ Mus musculus (house mouse) ]

Gene ID: 216028, updated on 9-Dec-2024

Summary

Official Symbol
Lrrtm3provided by MGI
Official Full Name
leucine rich repeat transmembrane neuronal 3provided by MGI
Primary source
MGI:MGI:2389177
See related
Ensembl:ENSMUSG00000042846 AllianceGenome:MGI:2389177
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630044H04Rik
Summary
Acts upstream of or within positive regulation of amyloid-beta formation and positive regulation of synapse assembly. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; future brain; and male reproductive gland or organ. Orthologous to human LRRTM3 (leucine rich repeat transmembrane neuronal 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in cerebellum adult (RPKM 10.4), cortex adult (RPKM 6.0) and 4 other tissues See more
Orthologs
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Genomic context

See Lrrtm3 in Genome Data Viewer
Location:
10 B4; 10 32.57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63764276..63926034, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63928497..64090255, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1121 Neighboring gene STARR-positive B cell enhancer ABC_E2940 Neighboring gene nuclear encoded tRNA serine 3 (anticodon TGA) Neighboring gene catenin alpha 3 Neighboring gene STARR-seq mESC enhancer starr_26935 Neighboring gene STARR-seq mESC enhancer starr_26936 Neighboring gene predicted gene, 30644 Neighboring gene STARR-seq mESC enhancer starr_26937 Neighboring gene STARR-seq mESC enhancer starr_26939 Neighboring gene STARR-seq mESC enhancer starr_26940 Neighboring gene STARR-seq mESC enhancer starr_26941 Neighboring gene STARR-seq mESC enhancer starr_26942 Neighboring gene STARR-seq mESC enhancer starr_26944 Neighboring gene STARR-seq mESC enhancer starr_26945 Neighboring gene STARR-seq mESC enhancer starr_26947 Neighboring gene STARR-seq mESC enhancer starr_26948 Neighboring gene STARR-seq mESC enhancer starr_26949 Neighboring gene predicted gene, 51834 Neighboring gene predicted gene 28881

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat transmembrane neuronal protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178678.4NP_848793.1  leucine-rich repeat transmembrane neuronal protein 3 precursor

    See identical proteins and their annotated locations for NP_848793.1

    Status: PROVISIONAL

    Source sequence(s)
    AC116138, AC158604
    Consensus CDS
    CCDS35925.1
    UniProtKB/Swiss-Prot
    Q14CH3, Q3TQA3, Q8BGJ7, Q8BZ81
    UniProtKB/TrEMBL
    Q8BZA0
    Related
    ENSMUSP00000101079.2, ENSMUST00000105439.2
    Conserved Domains (4) summary
    smart00013
    Location:3361
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:81300
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6686
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:133193
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    63764276..63926034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)