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LANCL3 LanC like family member 3 [ Homo sapiens (human) ]

Gene ID: 347404, updated on 23-Nov-2023

Summary

Official Symbol
LANCL3provided by HGNC
Official Full Name
LanC like family member 3provided by HGNC
Primary source
HGNC:HGNC:24767
See related
Ensembl:ENSG00000147036 AllianceGenome:HGNC:24767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in carbohydrate metabolic process. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See LANCL3 in Genome Data Viewer
Location:
Xp21.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (37571661..37684463)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (36975217..37088020)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37430914..37543716)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ferritin heavy chain 1 pseudogene 27 Neighboring gene family with sequence similarity 47 member D, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:37544835-37545346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:37545347-37545856 Neighboring gene H2A.L variant histone 1M, pseudogene Neighboring gene X-linked Kx blood group antigen, Kell and VPS13A binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29519 Neighboring gene cytochrome b-245 beta chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
lanC-like protein 3
Names
LanC lantibiotic synthetase component C-like 3
LanC like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016368.2 RefSeqGene

    Range
    5002..117804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170331.2NP_001163802.1  lanC-like protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001163802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC233297, AI989993, AK124915, BG944288
    Consensus CDS
    CCDS55398.1
    UniProtKB/Swiss-Prot
    A6NHE3, Q6ZV70
    Related
    ENSP00000367882.4, ENST00000378619.4
    Conserved Domains (1) summary
    cd04794
    Location:65414
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
  2. NM_198511.3NP_940913.1  lanC-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_940913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC233297, AI989993, AK124915, BG944288
    Consensus CDS
    CCDS14240.1
    UniProtKB/Swiss-Prot
    Q6ZV70
    Related
    ENSP00000367885.3, ENST00000378621.7
    Conserved Domains (1) summary
    cd04794
    Location:65367
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    37571661..37684463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543904.3XP_011542206.1  lanC-like protein 3 isoform X1

    Conserved Domains (1) summary
    cd04794
    Location:7232
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    36975217..37088020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326995.1XP_054182970.1  lanC-like protein 3 isoform X1