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QRFP pyroglutamylated RFamide peptide [ Homo sapiens (human) ]

Gene ID: 347148, updated on 1-Jun-2020

Summary

Official Symbol
QRFPprovided by HGNC
Official Full Name
pyroglutamylated RFamide peptideprovided by HGNC
Primary source
HGNC:HGNC:29982
See related
Ensembl:ENSG00000188710 MIM:609795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P518; 26RFa
Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See QRFP in Genome Data Viewer
Location:
9q34.12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (130892707..130896812, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133768815..133769225, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ABL breakpoint recombination region Neighboring gene exosome component 2 Neighboring gene ribosomal protein L37 pseudogene 17 Neighboring gene ABL proto-oncogene 1, non-receptor tyrosine kinase Neighboring gene fibrinogen C domain containing 1 Neighboring gene uncharacterized LOC105376297

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC119794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
orexigenic neuropeptide QRFP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
orexigenic neuropeptide QRFP receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
grooming behavior IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
orexigenic neuropeptide QRFP
Names
P518 precursor protein
RF(Arg-Phe)amide family 26 amino acid peptide (P518)
prepro-QRFP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198180.3NP_937823.1  orexigenic neuropeptide QRFP preproprotein

    See identical proteins and their annotated locations for NP_937823.1

    Status: REVIEWED

    Source sequence(s)
    AB109625, AL161733, CV575364
    Consensus CDS
    CCDS6936.1
    UniProtKB/Swiss-Prot
    P83859
    Related
    ENSP00000485512.1, ENST00000623824.2
    Conserved Domains (1) summary
    pfam11109
    Location:16135
    RFamide_26RFa; Orexigenic neuropeptide Qrfp/P518

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    130892707..130896812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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