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QRFP pyroglutamylated RFamide peptide [ Homo sapiens (human) ]

Gene ID: 347148, updated on 5-Aug-2022

Summary

Official Symbol
QRFPprovided by HGNC
Official Full Name
pyroglutamylated RFamide peptideprovided by HGNC
Primary source
HGNC:HGNC:29982
See related
Ensembl:ENSG00000188710 MIM:609795; AllianceGenome:HGNC:29982
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P518; 26RFa
Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See QRFP in Genome Data Viewer
Location:
9q34.12
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (130892707..130896812, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143097580..143101684, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133768094..133772199, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ABL proto-oncogene 1, non-receptor tyrosine kinase Neighboring gene Sharpr-MPRA regulatory region 7858 Neighboring gene Sharpr-MPRA regulatory region 3771 Neighboring gene fibrinogen C domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 15615 Neighboring gene FIBCD1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC119794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables orexigenic neuropeptide QRFP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables orexigenic neuropeptide QRFP receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in grooming behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
orexigenic neuropeptide QRFP
Names
P518 precursor protein
RF(Arg-Phe)amide family 26 amino acid peptide (P518)
prepro-26RFa
prepro-QRFP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198180.3NP_937823.1  orexigenic neuropeptide QRFP preproprotein

    See identical proteins and their annotated locations for NP_937823.1

    Status: REVIEWED

    Source sequence(s)
    AB109625, AL161733, CV575364
    Consensus CDS
    CCDS6936.1
    UniProtKB/Swiss-Prot
    P83859, Q495K6
    Related
    ENSP00000485512.1, ENST00000623824.2
    Conserved Domains (1) summary
    pfam11109
    Location:16135
    RFamide_26RFa; Orexigenic neuropeptide Qrfp/P518

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    130892707..130896812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    143097580..143101684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)