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Mal-B2 Maltase B2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34598, updated on 18-Sep-2024

Summary

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Official Symbol
Mal-B2provided by FlyBase
Official Full Name
Maltase B2provided by FlyBase
Primary source
FLYBASE:FBgn0032382
Locus tag
Dmel_CG14935
See related
AllianceGenome:FB:FBgn0032382
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14935; Dmel\CG14935; Drome_B2; FBgn0032382; mal_B2
Summary
Predicted to enable maltose alpha-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Mal-B2 in Genome Data Viewer
Location:
33A4-33A4; 2-45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11849958..11852881)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11849958..11852881)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphodiesterase 1c Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Maltase B1 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 33a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425
  2. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
  3. A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome. Ren J, et al. Hum Mol Genet, 2011 Sep 1. PMID 21653638, Free PMC Article
  4. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Sieber MH, et al. Cell Metab, 2009 Dec. PMID 19945405, Free PMC Article
  5. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Grönke S, et al. Cell Metab, 2005 May. PMID 16054079

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,4-glucosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
maltase B2
Names
CG14935-PA
CG14935-PE
CG14935-PF
Mal-B2-PA
Mal-B2-PE
Mal-B2-PF
NP_001188791.2
NP_609523.2
NP_723693.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11849958..11852881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135679.5 → NP_609523.2  maltase B2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609523.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPA2, Q8SYS2, Q9VKE5
    Related
    FBpp0079860
    Conserved Domains (3) summary
    cd11328
    Location:14 → 483
    AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
    TIGR02403
    Location:15 → 521
    trehalose_treC; alpha,alpha-phosphotrehalase
    cl02706
    Location:491 → 524
    Malt_amylase_C; Maltogenic Amylase, C-terminal domain

  2. NM_001201862.1 → NP_001188791.2  maltase B2, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4P1SA55, A9UND4
    Conserved Domains (2) summary
    cd11328
    Location:33 → 502
    AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
    cl02706
    Location:510 → 541
    Malt_amylase_C; Maltogenic Amylase, C-terminal domain

  3. NM_164975.3 → NP_723693.3  maltase B2, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4P1SA55, A9UND4
    Conserved Domains (2) summary
    cd11328
    Location:33 → 502
    AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
    cl02706
    Location:510 → 541
    Malt_amylase_C; Maltogenic Amylase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4P1SA55 A0A4P1SA55
Q8IPA2 Q8IPA2
Q8SYS2 Q8SYS2

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