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IFIT1 interferon induced protein with tetratricopeptide repeats 1 [ Homo sapiens (human) ]

Gene ID: 3434, updated on 1-Jun-2020

Summary

Official Symbol
IFIT1provided by HGNC
Official Full Name
interferon induced protein with tetratricopeptide repeats 1provided by HGNC
Primary source
HGNC:HGNC:5407
See related
Ensembl:ENSG00000185745 MIM:147690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C56; P56; G10P1; IFI56; ISG56; IFI-56; IFIT-1; IFNAI1; RNM561; IFI-56K
Summary
This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in adrenal (RPKM 10.7), spleen (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See IFIT1 in Genome Data Viewer
Location:
10q23.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (89392546..89406487)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91152303..91166244)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene interferon induced protein with tetratricopeptide repeats 6, pseudogene Neighboring gene interferon induced protein with tetratricopeptide repeats 1B Neighboring gene uncharacterized LOC107984251 Neighboring gene interferon induced protein with tetratricopeptide repeats 5 Neighboring gene solute carrier family 16 member 12 Neighboring gene SLC16A12 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr antagonizes IFIT1 (ISG56) mRNA induction in TZM-bl STING cells (TZM-bl cells engineered to express TMEM173 (STING)); IFIT1 is involved in viral recognition innate sensing within cell PubMed
vpr HIV-1 Vpr upregulates the gene expression of IFIT1 in human monocyte-derived dendritic cells PubMed
vpr HIV-1 Vpr upregulates the gene expression of IFIT1 in human monocyte-derived macrophages PubMed
Vpu vpu The expression of IFIT1 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed
capsid gag Infection with HIV-1 CA mutant N74D upregulates the expression of IFIT1 in primary human monocyte-derived macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to type I interferon IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular transport of viral protein in host cell IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
regulation of defense response to virus IEA
Inferred from Electronic Annotation
more info
 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
host cell IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interferon-induced protein with tetratricopeptide repeats 1
Names
interferon, alpha-inducible protein (MW 56kD)
interferon-induced 56 kDa protein
interferon-inducible mRNA 561

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270927.2NP_001257856.1  interferon-induced protein with tetratricopeptide repeats 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK308688, AL353146, BU625391, DA822484
    Conserved Domains (3) summary
    sd00006
    Location:252279
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:438470
    TPR_1; Tetratricopeptide repeat
    pfam13424
    Location:54127
    TPR_12; Tetratricopeptide repeat
  2. NM_001270928.2NP_001257857.1  interferon-induced protein with tetratricopeptide repeats 1 isoform 3

    See identical proteins and their annotated locations for NP_001257857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 5 encode the same isoform (3).
    Source sequence(s)
    AL353146, BU625391, DA822484, DB180094
    Consensus CDS
    CCDS59220.1
    UniProtKB/Swiss-Prot
    P09914
    Conserved Domains (3) summary
    sd00006
    Location:221248
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:407439
    TPR_1; Tetratricopeptide repeat
    pfam13424
    Location:2396
    TPR_12; Tetratricopeptide repeat
  3. NM_001270929.2NP_001257858.1  interferon-induced protein with tetratricopeptide repeats 1 isoform 3

    See identical proteins and their annotated locations for NP_001257858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 5 encode the same isoform (3).
    Source sequence(s)
    AL353146, BU625391, DB003897
    Consensus CDS
    CCDS59220.1
    UniProtKB/Swiss-Prot
    P09914
    Conserved Domains (3) summary
    sd00006
    Location:221248
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:407439
    TPR_1; Tetratricopeptide repeat
    pfam13424
    Location:2396
    TPR_12; Tetratricopeptide repeat
  4. NM_001270930.1NP_001257859.1  interferon-induced protein with tetratricopeptide repeats 1 isoform 3

    See identical proteins and their annotated locations for NP_001257859.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate internal exon and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 5 encode the same isoform (3).
    Source sequence(s)
    AL353146, BI670242, BU625391, DA822484, DB474377
    Consensus CDS
    CCDS59220.1
    UniProtKB/Swiss-Prot
    P09914
    Related
    ENSP00000441968.1, ENST00000546318.2
    Conserved Domains (3) summary
    sd00006
    Location:221248
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:407439
    TPR_1; Tetratricopeptide repeat
    pfam13424
    Location:2396
    TPR_12; Tetratricopeptide repeat
  5. NM_001548.5NP_001539.3  interferon-induced protein with tetratricopeptide repeats 1 isoform 1

    See identical proteins and their annotated locations for NP_001539.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK314588, AL353146, BU625391
    Consensus CDS
    CCDS31243.1
    UniProtKB/Swiss-Prot
    P09914
    Related
    ENSP00000360869.3, ENST00000371804.4
    Conserved Domains (2) summary
    sd00006
    Location:252279
    TPR; TPR repeat [structural motif]
    cl26002
    Location:55466
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    89392546..89406487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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