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NACA2 nascent polypeptide associated complex subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 342538, updated on 1-Mar-2024

Summary

Official Symbol
NACA2provided by HGNC
Official Full Name
nascent polypeptide associated complex subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:23290
See related
Ensembl:ENSG00000253506 MIM:609274; AllianceGenome:HGNC:23290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANAC; NACAL
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See NACA2 in Genome Data Viewer
Location:
17q23.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (61590421..61591219, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (62459278..62460076, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (59667782..59668580, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59494097-59494644 Neighboring gene Sharpr-MPRA regulatory region 1503 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:59504513-59505712 Neighboring gene long intergenic non-protein coding RNA 2875 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:59521182-59521392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59529753-59530594 Neighboring gene uncharacterized LOC124904042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:59531395-59532276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:59532277-59533157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59539816-59540478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59541142-59541803 Neighboring gene Sharpr-MPRA regulatory region 11492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59553878-59554580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59554581-59555281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59563448-59564310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59564311-59565173 Neighboring gene T-box transcription factor 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59591549-59592049 Neighboring gene Sharpr-MPRA regulatory region 7395 Neighboring gene BRCA1 interacting helicase 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:59835525-59836270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12535 Neighboring gene VISTA enhancer hs778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12536 Neighboring gene integrator complex subunit 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nascent polypeptide-associated complex alpha subunit 2 (NACA2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC71999

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nascent polypeptide-associated complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nascent polypeptide-associated complex subunit alpha-2
Names
IgE autoantigen alpha-nascent polypeptide-associated complex
alpha-NAC protein
hom s 2.01 protein
nascent polypeptide associated complex alpha subunit 2
nascent polypeptide-associated complex, alpha polypeptide, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426702.1NP_001413631.1  nascent polypeptide-associated complex subunit alpha-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate allele of the gene on T2T-CHM13 assembly, which has a SNP (rs17610181) at NC_060941.1:62459449 that introduces a premature stop codon. The encoded 196aa protein (isoform 2) is truncated at the C-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    CP068261
  2. NM_199290.4NP_954984.1  nascent polypeptide-associated complex subunit alpha-2 isoform 1

    See identical proteins and their annotated locations for NP_954984.1

    Status: VALIDATED

    Source sequence(s)
    AC002994, BC062710
    Consensus CDS
    CCDS11630.1
    UniProtKB/Swiss-Prot
    Q2VIR9, Q9H009
    Related
    ENSP00000427802.1, ENST00000521764.3
    Conserved Domains (2) summary
    cd14415
    Location:174214
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    pfam01849
    Location:82128
    NAC; NAC domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    61590421..61591219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    62459278..62460076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)