U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SMTNL2 smoothelin like 2 [ Homo sapiens (human) ]

Gene ID: 342527, updated on 9-Jun-2025
Official Symbol
SMTNL2provided by HGNC
Official Full Name
smoothelin like 2provided by HGNC
Primary source
HGNC:HGNC:24764
See related
Ensembl:ENSG00000188176 AllianceGenome:HGNC:24764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in kidney (RPKM 11.1), prostate (RPKM 2.3) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See SMTNL2 in Genome Data Viewer
Location:
17p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4584007..4608319)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4473884..4498054)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4487302..4511614)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene gamma-glutamyltransferase 6 Neighboring gene thioredoxin pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4485577-4486150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4486943-4487562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4487563-4488182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4488803-4489420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4496171-4496742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4501973-4502865 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:4502866-4503758 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:4503759-4504651 Neighboring gene long intergenic non-protein coding RNA 1996 Neighboring gene uncharacterized LOC105371498 Neighboring gene RNA, U6 small nuclear 955, pseudogene

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ42461, MGC131847, MGC138382
Preferred Names
smoothelin-like protein 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114974.2NP_001108446.1  smoothelin-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001108446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC118754, BC105050, BC110859, DA822419, DB557882
    Consensus CDS
    CCDS45583.1
    UniProtKB/Swiss-Prot
    Q2TAL5, Q6ZVK6
    Related
    ENSP00000373964.4, ENST00000389313.9
    Conserved Domains (2) summary
    cd00014
    Location:354458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl01090
    Location:5692
    SlyX; SlyX
  2. NM_001375361.1NP_001362290.1  smoothelin-like protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC118754
    Conserved Domains (2) summary
    PRK09039
    Location:884
    PRK09039; peptidoglycan -binding protein
    pfam00307
    Location:273378
    CH; Calponin homology (CH) domain
  3. NM_198501.3NP_940903.2  smoothelin-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_940903.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    AK124452, BC105050, BC110859, DA822419, DB557882
    Consensus CDS
    CCDS11048.1
    UniProtKB/Swiss-Prot
    Q2TAL5
    Related
    ENSP00000345143.4, ENST00000338859.8
    Conserved Domains (1) summary
    cd00014
    Location:210314
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4584007..4608319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4473884..4498054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)