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IDH3G isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma [ Homo sapiens (human) ]

Gene ID: 3421, updated on 1-Jun-2020

Summary

Official Symbol
IDH3Gprovided by HGNC
Official Full Name
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:5386
See related
Ensembl:ENSG00000067829 MIM:300089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H-IDHG
Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 22.6), heart (RPKM 18.4) and 25 other tissues See more
Orthologs

Genomic context

See IDH3G in Genome Data Viewer
Location:
Xq28
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (153785768..153794375, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153051221..153059978, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723591 Neighboring gene plexin B3 Neighboring gene SRSF protein kinase 3 Neighboring gene CRISPRi-validated cis-regulatory element chrX.2654 Neighboring gene signal sequence receptor subunit 4 Neighboring gene PDZ domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of IDH3G by shRNA significantly inhibits HIV-1 replication in CD4+ T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies IDH3G, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD binding IEA
Inferred from Electronic Annotation
more info
 
isocitrate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
isocitrate dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
isocitrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Names
IDH-gamma
NAD (H)-specific isocitrate dehydrogenase gamma subunit
NAD(+)-specific ICDH subunit gamma
NAD+-specific ICDH
isocitrate dehydrogenase (NAD(+)) 3 gamma
isocitrate dehydrogenase 3 (NAD(+)) gamma
isocitrate dehydrogenase 3 (NAD+) gamma
isocitrate dehydrogenase 3 gamma
isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit
isocitric dehydrogenase subunit gamma
NP_004126.1
NP_777358.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004135.4NP_004126.1  isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_004126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC000933, BI831096
    Consensus CDS
    CCDS14730.1
    UniProtKB/Swiss-Prot
    P51553
    Related
    ENSP00000217901.5, ENST00000217901.10
    Conserved Domains (1) summary
    TIGR00175
    Location:52383
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type
  2. NM_174869.3NP_777358.1  isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region resulting in a frameshift, compared to variant 1. Variant 2 encodes a shorter isoform (b) with a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC000933, BI831096, U69268
    Consensus CDS
    CCDS44019.1
    UniProtKB/Swiss-Prot
    P51553
    UniProtKB/TrEMBL
    O15384
    Related
    ENSP00000359110.3, ENST00000370092.7
    Conserved Domains (1) summary
    TIGR00175
    Location:52364
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    153785768..153794375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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