LINGO4 leucine rich repeat and Ig domain containing 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINGO4provided by HGNC
Official Full Name: leucine rich repeat and Ig domain containing 4provided by HGNC
Primary source: HGNC:HGNC:31814
See related: Ensembl:ENSG00000213171 MIM:609794; AllianceGenome:HGNC:31814
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LRRN6D; DAAT9248; PRO34002
Summary: Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal (RPKM 1.2), testis (RPKM 0.4) and 16 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q21.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (151800264..151805419, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (150923752..150928907, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (151772740..151777895, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

variants in coding region of the LINGO4 gene may play little or no role in the risk of Essential tremor susceptibility
Title: No evidence of association between the LINGO4 gene and essential tremor in Chinese Han patients.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-34816 (e-PCR)
- UniSTS:59573

RH16275 (e-PCR)
- UniSTS:22998

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4

Names: leucine-rich repeat neuronal protein 6D

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004432.4 → NP_001004432.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 precursor

See identical proteins and their annotated locations for NP_001004432.1

Status: VALIDATED

Source sequence(s)

AL589765

Consensus CDS

CCDS30855.1

UniProtKB/Swiss-Prot

Q6UY18

Related

ENSP00000357810.4, ENST00000368820.4

Conserved Domains (7) summary

smart00013
Location:31 → 64

LRRNT; Leucine rich repeat N-terminal domain

smart00410
Location:420 → 501

IG_like; Immunoglobulin like

cd00116
Location:87 → 320

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:350 → 362

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:86 → 109

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:65 → 120

LRR_8; Leucine rich repeat

cl11960
Location:431 → 501

Ig; Immunoglobulin domain