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LINGO4 leucine rich repeat and Ig domain containing 4 [ Homo sapiens (human) ]

Gene ID: 339398, updated on 11-Jun-2021

Summary

Official Symbol
LINGO4provided by HGNC
Official Full Name
leucine rich repeat and Ig domain containing 4provided by HGNC
Primary source
HGNC:HGNC:31814
See related
Ensembl:ENSG00000213171 MIM:609794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRN6D; DAAT9248; PRO34002
Expression
Broad expression in adrenal (RPKM 1.2), testis (RPKM 0.4) and 16 other tissues See more
Orthologs
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Genomic context

See LINGO4 in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151800264..151805419, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151772740..151777895, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tudor and KH domain containing Neighboring gene chloride nucleotide-sensitive channel 1A pseudogene Neighboring gene TDRKH antisense RNA 1 Neighboring gene RAR related orphan receptor C Neighboring gene C2CD4D and THEM5 antisense RNA 1 Neighboring gene C2 calcium dependent domain containing 4D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4
Names
leucine-rich repeat neuronal protein 6D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004432.4NP_001004432.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 precursor

    See identical proteins and their annotated locations for NP_001004432.1

    Status: VALIDATED

    Source sequence(s)
    AL589765
    Consensus CDS
    CCDS30855.1
    UniProtKB/Swiss-Prot
    Q6UY18
    Related
    ENSP00000357810.4, ENST00000368820.4
    Conserved Domains (7) summary
    smart00013
    Location:3164
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:420501
    IG_like; Immunoglobulin like
    cd00116
    Location:87320
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:350362
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:86109
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:65120
    LRR_8; Leucine rich repeat
    cl11960
    Location:431501
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151800264..151805419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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