U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fkbp15 FK506 binding protein 15 [ Mus musculus (house mouse) ]

Gene ID: 338355, updated on 12-May-2024

Summary

Go to the top of the page Help
Official Symbol
Fkbp15provided by MGI
Official Full Name
FK506 binding protein 15provided by MGI
Primary source
MGI:MGI:2444782
See related
Ensembl:ENSMUSG00000066151 AllianceGenome:MGI:2444782
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FKBO133; FKBP-15; FKBP133; FKBP-133; mKIAA0674; C430014M02Rik
Summary
Predicted to enable actin binding activity. Predicted to act upstream of or within endocytosis. Located in actin cytoskeleton; endosome; and growth cone. Is expressed in several structures, including central nervous system; lung; neural retina; peripheral nervous system ganglion; and thymus. Orthologous to human FKBP15 (FKBP prolyl isomerase family member 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 9.8), lung adult (RPKM 9.4) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fkbp15 in Genome Data Viewer
Location:
4 B3; 4 33.08 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62218579..62278828, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62300342..62360596, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23148 Neighboring gene solute carrier family 31, member 2 Neighboring gene STARR-seq mESC enhancer starr_10422 Neighboring gene STARR-positive B cell enhancer ABC_E1277 Neighboring gene STARR-seq mESC enhancer starr_10423 Neighboring gene solute carrier family 31, member 1 Neighboring gene cell division cycle 26 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62069546-62069847 Neighboring gene pre-mRNA processing factor 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. Nakajima O, et al. Biochem Biophys Res Commun, 2006 Jul 21. PMID 16756961
  2. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Tyrrell BJ, et al. Pigment Cell Melanoma Res, 2016 Sep. PMID 27390154, Free PMC Article
  3. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0674, MGC169330

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
FK506-binding protein 15
Names
133 kDa FK506-binding protein
133 kDa FKBP
FK506-binding protein 133
WAFL
NP_001038993.1
NP_001342314.1
XP_006538097.1
XP_030109487.1
XP_036020098.1
XP_036020099.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045528.3 → NP_001038993.1  FK506-binding protein 15 isoform 1

    See identical proteins and their annotated locations for NP_001038993.1

    Status: VALIDATED

    Source sequence(s)
    AL683829, AL732548
    Consensus CDS
    CCDS51201.1
    UniProtKB/Swiss-Prot
    Q3TSY4, Q5SQG3, Q6P9Q6, Q80TU5
    Related
    ENSMUSP00000081575.4, ENSMUST00000084527.10
    Conserved Domains (4) summary
    pfam00254
    Location:192 → 285
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam07321
    Location:677 → 806
    YscO; Type III secretion protein YscO
    cl23720
    Location:679 → 774
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23765
    Location:596 → 750
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_001355385.2 → NP_001342314.1  FK506-binding protein 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683829, AL732548
    UniProtKB/TrEMBL
    B2RQ18
    Conserved Domains (4) summary
    pfam00254
    Location:192 → 285
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    cl25732
    Location:556 → 915
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26464
    Location:934 → 1119
    Atrophin-1; Atrophin-1 family
    cl28087
    Location:378 → 489
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62218579..62278828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164206.1 → XP_036020099.1  FK506-binding protein 15 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:505 → 690
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:122 → 430
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_030253627.1 → XP_030109487.1  FK506-binding protein 15 isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:495 → 680
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:117 → 456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006538034.4 → XP_006538097.1  FK506-binding protein 15 isoform X1

    UniProtKB/TrEMBL
    A0A6I8MWZ0
    Related
    ENSMUSP00000159322.2, ENSMUST00000239461.2
    Conserved Domains (4) summary
    PHA03247
    Location:944 → 1129
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:561 → 890
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK10263
    Location:378 → 489
    PRK10263; DNA translocase FtsK; Provisional
    pfam00254
    Location:192 → 285
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  4. XM_036164205.1 → XP_036020098.1  FK506-binding protein 15 isoform X2

    UniProtKB/TrEMBL
    A0A6I8MWZ0
    Conserved Domains (3) summary
    PHA03247
    Location:792 → 977
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:409 → 738
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00254
    Location:40 → 133
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9Q6.2 GenPept UniProtKB/Swiss-Prot:Q6P9Q6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools