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FKBP15 FK506 binding protein 15 [ Homo sapiens (human) ]

Gene ID: 23307, updated on 26-Nov-2016
Official Symbol
FKBP15provided by HGNC
Official Full Name
FK506 binding protein 15provided by HGNC
Primary source
HGNC:HGNC:23397
See related
Ensembl:ENSG00000119321 Vega:OTTHUMG00000020518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP133; PPP1R76; KIAA0674
Orthologs
Location:
9q32
Exon count:
28
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (113165036..113221361, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115927800..115983641, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 225 member A (non-protein coding) Neighboring gene solute carrier family 31 member 2 Neighboring gene solute carrier family 31 member 1 Neighboring gene uncharacterized LOC107987119 Neighboring gene cell division cycle 26

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin filament IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
FK506-binding protein 15
Names
133 kDa FK506-binding protein
133 kDa FKBP
FK506 binding protein 15, 133kDa
FK506-binding protein 133kDa
FKBP-133
FKBP-15
WAFL
WASP and FKBP-like protein
protein phosphatase 1, regulatory subunit 76
NP_056073.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015258.1NP_056073.1  FK506-binding protein 15

    See identical proteins and their annotated locations for NP_056073.1

    Status: VALIDATED

    Source sequence(s)
    AB014574, BC077732, BQ646813, DA238568, DC321217
    Consensus CDS
    CCDS48007.1
    UniProtKB/Swiss-Prot
    Q5T1M5
    Related
    ENSP00000238256, ENST00000238256
    Conserved Domains (8) summary
    COG1340
    Location:511781
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam05029
    Location:589777
    TIMELESS_C; Timeless protein C terminal region
    pfam00254
    Location:193286
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam10211
    Location:715780
    Ax_dynein_light; Axonemal dynein light chain
    pfam14988
    Location:694871
    DUF4515; Domain of unknown function (DUF4515)
    cl00599
    Location:10141072
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    cl02488
    Location:686908
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:70168
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

    Range
    113165036..113221361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014552.1XP_016870041.1  

  2. XM_006717018.2XP_006717081.1  

    UniProtKB/Swiss-Prot
    Q5T1M5
    Conserved Domains (9) summary
    pfam00254
    Location:193286
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam10211
    Location:705770
    Ax_dynein_light; Axonemal dynein light chain
    pfam13863
    Location:645738
    DUF4200; Domain of unknown function (DUF4200)
    pfam14988
    Location:684861
    DUF4515; Domain of unknown function (DUF4515)
    pfam15619
    Location:578770
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl00599
    Location:10041062
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    cl02488
    Location:676898
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:514700
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17171
    Location:70168
    PH-like; Pleckstrin homology-like domain
  3. XM_006717019.1XP_006717082.1  

    Conserved Domains (8) summary
    pfam05029
    Location:521709
    TIMELESS_C; Timeless protein C terminal region
    pfam00254
    Location:125218
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam10211
    Location:647712
    Ax_dynein_light; Axonemal dynein light chain
    pfam12795
    Location:588807
    MscS_porin; Mechanosensitive ion channel porin domain
    pfam14662
    Location:465677
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl00599
    Location:9461004
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    cl02488
    Location:618840
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:2100
    PH-like; Pleckstrin homology-like domain

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    116074347..116130427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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