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FKBP15 FKBP prolyl isomerase 15 [ Homo sapiens (human) ]

Gene ID: 23307, updated on 18-Aug-2020

Summary

Official Symbol
FKBP15provided by HGNC
Official Full Name
FKBP prolyl isomerase 15provided by HGNC
Primary source
HGNC:HGNC:23397
See related
Ensembl:ENSG00000119321 MIM:617398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP133; PPP1R76; KIAA0674
Expression
Ubiquitous expression in spleen (RPKM 13.2), appendix (RPKM 13.2) and 25 other tissues See more
Orthologs

Genomic context

See FKBP15 in Genome Data Viewer
Location:
9q32
Exon count:
28
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (113161006..113221325, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115927800..115983641, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 225 member A Neighboring gene Sharpr-MPRA regulatory region 7760 Neighboring gene solute carrier family 31 member 2 Neighboring gene uncharacterized LOC107987119 Neighboring gene solute carrier family 31 member 1 Neighboring gene cell division cycle 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 
growth cone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
FK506-binding protein 15
Names
133 kDa FK506-binding protein
133 kDa FKBP
FK506 binding protein 15, 133kDa
FK506-binding protein 133kDa
FKBP-133
FKBP-15
WAFL
WASP and FKBP-like protein
protein phosphatase 1, regulatory subunit 76
NP_056073.1
XP_006717081.1
XP_006717082.1
XP_016870041.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015258.2NP_056073.1  FK506-binding protein 15

    See identical proteins and their annotated locations for NP_056073.1

    Status: VALIDATED

    Source sequence(s)
    AB014574, AL449105, BC077732, BQ646813, DA238568
    Consensus CDS
    CCDS48007.1
    UniProtKB/Swiss-Prot
    Q5T1M5
    Related
    ENSP00000238256.3, ENST00000238256.8
    Conserved Domains (8) summary
    COG1340
    Location:511781
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam05029
    Location:589777
    TIMELESS_C; Timeless protein C terminal region
    pfam00254
    Location:193286
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam10211
    Location:715780
    Ax_dynein_light; Axonemal dynein light chain
    pfam14988
    Location:694871
    DUF4515; Domain of unknown function (DUF4515)
    cl00599
    Location:10141072
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    cl02488
    Location:686908
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:70168
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    113161006..113221325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014552.1XP_016870041.1  FK506-binding protein 15 isoform X3

  2. XM_006717018.2XP_006717081.1  FK506-binding protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5T1M5
    Conserved Domains (9) summary
    pfam00254
    Location:193286
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam10211
    Location:705770
    Ax_dynein_light; Axonemal dynein light chain
    pfam13863
    Location:645738
    DUF4200; Domain of unknown function (DUF4200)
    pfam14988
    Location:684861
    DUF4515; Domain of unknown function (DUF4515)
    pfam15619
    Location:578770
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl00599
    Location:10041062
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    cl02488
    Location:676898
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:514700
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17171
    Location:70168
    PH-like; Pleckstrin homology-like domain
  3. XM_006717019.1XP_006717082.1  FK506-binding protein 15 isoform X2

    Conserved Domains (8) summary
    pfam05029
    Location:521709
    TIMELESS_C; Timeless protein C terminal region
    pfam00254
    Location:125218
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam10211
    Location:647712
    Ax_dynein_light; Axonemal dynein light chain
    pfam12795
    Location:588807
    MscS_porin; Mechanosensitive ion channel porin domain
    pfam14662
    Location:465677
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl00599
    Location:9461004
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    cl02488
    Location:618840
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:2100
    PH-like; Pleckstrin homology-like domain
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