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H2BP1 H2B histone pseudogene 1 [ Homo sapiens (human) ]

Gene ID: 337875, updated on 22-Oct-2024

Summary

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Official Symbol
H2BP1provided by HGNC
Official Full Name
H2B histone pseudogene 1provided by HGNC
Primary source
HGNC:HGNC:20560
See related
Ensembl:ENSG00000291123 AllianceGenome:HGNC:20560
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIST2H2BA
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a histone pseudogene found on chromosome 1. [provided by RefSeq, Oct 2015]
Expression
Broad expression in ovary (RPKM 2.4), prostate (RPKM 2.1) and 20 other tissues See more
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Genomic context

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See H2BP1 in Genome Data Viewer
Location:
1p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (121107175..121117292, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (121116558..121126675, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120905993..120916108)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 D4-like Neighboring gene H3 histone pseudogene 4 Neighboring gene uncharacterized LOC100996318 Neighboring gene Fc gamma receptor Ib, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1254 Neighboring gene ribosomal protein L22 pseudogene 6 Neighboring gene family with sequence similarity 72 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal cell line. González-Romero R, et al. Mol Biol Evol, 2010 Aug. PMID 20194426
  2. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Hublitz P, et al. Genes Dev, 2005 Dec 1. PMID 16322561, Free PMC Article
  3. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Hughes CM, et al. Mol Cell, 2004 Feb 27. PMID 14992727
  4. The human and mouse replication-dependent histone genes. Marzluff WF, et al. Genomics, 2002 Nov. PMID 12408966
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Other Names

  • histone 2, H2ba
  • histone cluster 2 H2B family member a (pseudogene)
  • histone cluster 2, H2ba (pseudogene)

Clone Names

  • MGC126029, MGC126031

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027337.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC244453
    Related
    ENST00000430394.3

  2. NR_160942.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC244453
    Related
    ENST00000770023.1

  3. NR_160944.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC244453

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    121107175..121117292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    121116558..121126675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002621.1: Suppressed sequence

    Description
    NG_002621.1: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials