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IAPP islet amyloid polypeptide [ Homo sapiens (human) ]

Gene ID: 3375, updated on 26-Apr-2020

Summary

Official Symbol
IAPPprovided by HGNC
Official Full Name
islet amyloid polypeptideprovided by HGNC
Primary source
HGNC:HGNC:5329
See related
Ensembl:ENSG00000121351 MIM:147940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP; IAP
Summary
This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]
Expression
Restricted expression toward pancreas (RPKM 16.6) See more
Orthologs

Genomic context

See IAPP in Genome Data Viewer
Location:
12p12.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (21354960..21379980)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21525802..21532914)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SLCO1B3-SLCO1B7 readthrough Neighboring gene solute carrier organic anion transporter family member 1B7 (putative) Neighboring gene solute carrier organic anion transporter family member 1B1 Neighboring gene solute carrier organic anion transporter family member 1A2 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene elongin C pseudogene 31 Neighboring gene RecQ like helicase Neighboring gene golgi transport 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
amylin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of amyloid fibril formation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitochondrion organization TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein complex assembly TAS
Traceable Author Statement
more info
PubMed 
positive regulation of MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cytosolic calcium ion concentration NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of protein kinase A signaling NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of protein kinase B signaling NAS
Non-traceable Author Statement
more info
PubMed 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
islet amyloid polypeptide
Names
Islet amyloid polypeptide (diabetes-associated peptide; amylin)
amylin
diabetes-associated peptide
insulinoma amyloid peptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000415.3NP_000406.1  islet amyloid polypeptide preproprotein

    See identical proteins and their annotated locations for NP_000406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BQ548699, J04422, X14905
    Consensus CDS
    CCDS8688.1
    UniProtKB/Swiss-Prot
    P10997
    UniProtKB/TrEMBL
    A0A024RAU1
    Related
    ENSP00000240652.3, ENST00000240652.8
    Conserved Domains (1) summary
    smart00113
    Location:3273
    CALCITONIN; calcitonin
  2. NM_001329201.1NP_001316130.1  islet amyloid polypeptide preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA429852, AA446156, BQ548699, J04422, X14905
    Consensus CDS
    CCDS8688.1
    UniProtKB/Swiss-Prot
    P10997
    UniProtKB/TrEMBL
    A0A024RAU1
    Related
    ENSP00000437357.1, ENST00000539393.5
    Conserved Domains (1) summary
    smart00113
    Location:3273
    CALCITONIN; calcitonin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    21354960..21379980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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