U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HTR5A 5-hydroxytryptamine receptor 5A [ Homo sapiens (human) ]

Gene ID: 3361, updated on 3-May-2025
Official Symbol
HTR5Aprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 5Aprovided by HGNC
Primary source
HGNC:HGNC:5300
See related
Ensembl:ENSG00000157219 MIM:601305; AllianceGenome:HGNC:5300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-HT5A
Summary
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 2.3) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See HTR5A in Genome Data Viewer
Location:
7q36.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (155070324..155087392)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (156245922..156265002)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (154862034..154879102)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene PAX interacting protein 1 Neighboring gene uncharacterized LOC124901781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154795729-154796230 Neighboring gene PAXIP1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:154862583-154863409 Neighboring gene HTR5A antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:154914484-154915093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154959387-154959888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154959889-154960388 Neighboring gene uncharacterized LOC105375584 Neighboring gene RN7SK pseudogene 280

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association study of the five-factor model of personality in young Korean women.
EBI GWAS Catalog
Genome-wide interaction study of smoking and bladder cancer risk.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC138226

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
5-hydroxytryptamine receptor 5A
Names
5-HT-5
5-HT-5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_044997.1 RefSeqGene

    Range
    5001..22069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1057

mRNA and Protein(s)

  1. NM_024012.4NP_076917.1  5-hydroxytryptamine receptor 5A

    See identical proteins and their annotated locations for NP_076917.1

    Status: REVIEWED

    Source sequence(s)
    AC092628, AC093726, BC112021, BX538209
    Consensus CDS
    CCDS5936.1
    UniProtKB/Swiss-Prot
    P47898, Q2M2D2
    UniProtKB/TrEMBL
    A4D2N2, Q14D80
    Related
    ENSP00000287907.2, ENST00000287907.3
    Conserved Domains (1) summary
    cd15328
    Location:41349
    7tmA_5-HT5; serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    155070324..155087392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    156245922..156265002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487586.1 RNA Sequence