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HTR5A 5-hydroxytryptamine receptor 5A [ Homo sapiens (human) ]

Gene ID: 3361, updated on 1-Jun-2020

Summary

Official Symbol
HTR5Aprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 5Aprovided by HGNC
Primary source
HGNC:HGNC:5300
See related
Ensembl:ENSG00000157219 MIM:601305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-HT5A
Summary
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 2.3) See more
Orthologs

Genomic context

See HTR5A in Genome Data Viewer
Location:
7q36.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (155070324..155087392)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (154862034..154879102)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene PAXIP1 antisense RNA 2 Neighboring gene PAX interacting protein 1 Neighboring gene PAXIP1 divergent transcript Neighboring gene HTR5A antisense RNA 1 Neighboring gene uncharacterized LOC105375584 Neighboring gene RN7SK pseudogene 280

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of the five-factor model of personality in young Korean women.
NHGRI GWA Catalog
Genome-wide interaction study of smoking and bladder cancer risk.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC138226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 5A
Names
5-HT-5
5-HT-5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_044997.1 RefSeqGene

    Range
    5001..22069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024012.4NP_076917.1  5-hydroxytryptamine receptor 5A

    See identical proteins and their annotated locations for NP_076917.1

    Status: REVIEWED

    Source sequence(s)
    AC092628, AC093726, BC112021, BX538209
    Consensus CDS
    CCDS5936.1
    UniProtKB/Swiss-Prot
    P47898
    UniProtKB/TrEMBL
    A4D2N2
    Related
    ENSP00000287907.2, ENST00000287907.3
    Conserved Domains (1) summary
    cd15328
    Location:41349
    7tmA_5-HT5; serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    155070324..155087392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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