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HTR5A 5-hydroxytryptamine receptor 5A [ Homo sapiens (human) ]

Gene ID: 3361, updated on 3-May-2025
Official Symbol
HTR5Aprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 5Aprovided by HGNC
Primary source
HGNC:HGNC:5300
See related
Ensembl:ENSG00000157219 MIM:601305; AllianceGenome:HGNC:5300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-HT5A
Summary
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 2.3) See more
Orthologs
mouse all
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See HTR5A in Genome Data Viewer
Location:
7q36.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (155070324..155087392)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (156245922..156265002)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (154862034..154879102)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene PAX interacting protein 1 Neighboring gene uncharacterized LOC124901781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154795729-154796230 Neighboring gene PAXIP1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:154862583-154863409 Neighboring gene HTR5A antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:154914484-154915093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154959387-154959888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154959889-154960388 Neighboring gene uncharacterized LOC105375584 Neighboring gene RN7SK pseudogene 280

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia. Iwata N, et al. Mol Psychiatry, 2001 Mar. PMID 11317225
  2. Identification and functional significance of N-glycosylation of the 5-ht5A receptor. Dutton AC, et al. Neurochem Int, 2008 Feb. PMID 17881091
  3. 5-ht5A receptors as a therapeutic target. Thomas DR. Pharmacol Ther, 2006 Sep. PMID 16516972
  4. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Dietz BM, et al. Brain Res Mol Brain Res, 2005 Aug 18. PMID 15921820, Free PMC Article
  5. Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors. Khorana N, et al. J Med Chem, 2003 Aug 28. PMID 12930153

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 5-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion.
    Title: 5-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion.
  2. results provide further supportive evidence of the effect of HTR1A and HTR5A on the etiology of schizophrenia and suggest that the selected genetic variations in HTR5A may be involved in impaired executive function.
    Title: Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function.
  3. Results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression
    Title: Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression.
  4. Childhood anxiousness did not mediate the effects of HTR2A and HTR5A on mood disorders.
    Title: Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.
  5. Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels
    Title: Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels.
  6. Association of a SNP of HTR5A gene is a susceptibility factor to bipolar disease in Bulgarian population.
    Title: Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.
  7. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
    Title: Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.
  8. In individuals in Brazil with the A/A variant of the -1438G/A polymorphism of the 2A receptor gene, the effect of cultural consonance in family life on depressive symptoms over a 2 year period was larger than those with the G/A or G/G variants.
    Title: Cultural consonance, a 5HT2A receptor polymorphism, and depressive symptoms: a longitudinal study of gene x culture interaction in urban Brazil.
  9. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
  10. N-glycosylation of the N6 residue is important for the membrane expression of this 5-HT5A neurotransmitter receptor; a requirement for receptor function.
    Title: Identification and functional significance of N-glycosylation of the 5-ht5A receptor.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of the five-factor model of personality in young Korean women.
EBI GWAS Catalog
Genome-wide interaction study of smoking and bladder cancer risk.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC138226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables Gi/o-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Gi/o-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
5-hydroxytryptamine receptor 5A
Names
5-HT-5
5-HT-5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_044997.1 RefSeqGene

    Range
    5001..22069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1057

mRNA and Protein(s)

  1. NM_024012.4 → NP_076917.1  5-hydroxytryptamine receptor 5A

    See identical proteins and their annotated locations for NP_076917.1

    Status: REVIEWED

    Source sequence(s)
    AC092628, AC093726, BC112021, BX538209
    Consensus CDS
    CCDS5936.1
    UniProtKB/Swiss-Prot
    P47898, Q2M2D2
    UniProtKB/TrEMBL
    A4D2N2, Q14D80
    Related
    ENSP00000287907.2, ENST00000287907.3
    Conserved Domains (1) summary
    cd15328
    Location:41 → 349
    7tmA_5-HT5; serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    155070324..155087392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    156245922..156265002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487586.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47898.1 GenPept UniProtKB/Swiss-Prot:P47898

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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