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Htr5a 5-hydroxytryptamine (serotonin) receptor 5A [ Mus musculus (house mouse) ]

Gene ID: 15563, updated on 1-Mar-2024

Summary

Official Symbol
Htr5aprovided by MGI
Official Full Name
5-hydroxytryptamine (serotonin) receptor 5Aprovided by MGI
Primary source
MGI:MGI:96283
See related
Ensembl:ENSMUSG00000039106 AllianceGenome:MGI:96283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Htr5
Summary
Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in Golgi apparatus; perikaryon; and rough endoplasmic reticulum. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adipose tissue; brain; eye; female reproductive system; and gut. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.1), frontal lobe adult (RPKM 2.0) and 4 other tissues See more
Orthologs
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Genomic context

See Htr5a in Genome Data Viewer
Location:
5 B1; 5 13.24 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (28046836..28059403)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (27841716..27855086)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene PAX interacting (with transcription-activation domain) protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3565 Neighboring gene STARR-seq mESC enhancer starr_12707 Neighboring gene STARR-seq mESC enhancer starr_12709 Neighboring gene predicted gene, 20239 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) pseudogene Neighboring gene predicted gene, 17695

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 5A
Names
5-HT-5
5-HT-5A
5-HT5A
serotonin receptor 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420120.1NP_001407049.1  5-hydroxytryptamine receptor 5A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132397
  2. NM_008314.3NP_032340.2  5-hydroxytryptamine receptor 5A isoform 1

    See identical proteins and their annotated locations for NP_032340.2

    Status: VALIDATED

    Source sequence(s)
    AC132397
    Consensus CDS
    CCDS19141.1
    UniProtKB/Swiss-Prot
    P30966, Q3URB0
    Related
    ENSMUSP00000038884.6, ENSMUST00000036227.7
    Conserved Domains (1) summary
    pfam00001
    Location:57338
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    28046836..28059403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)