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HTR1F 5-hydroxytryptamine receptor 1F [ Homo sapiens (human) ]

Gene ID: 3355, updated on 1-Jun-2020

Summary

Official Symbol
HTR1Fprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 1Fprovided by HGNC
Primary source
HGNC:HGNC:5292
See related
Ensembl:ENSG00000179097 MIM:182134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5HT6; MR77; 5-HT1F; HTR1EL; 5-HT-1F
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See HTR1F in Genome Data Viewer
Location:
3p11.2-p11.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (87792706..87994856)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (87841929..88043964)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377198 Neighboring gene RNA, U6 small nuclear 873, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr3.2983 Neighboring gene CRISPRi-validated cis-regulatory element chr3.2985 Neighboring gene RNA, U6atac small nuclear 6, pseudogene Neighboring gene CGG triplet repeat binding protein 1 Neighboring gene zinc finger protein 654 Neighboring gene chromobox 5 pseudogene 1 Neighboring gene chromosome 3 open reading frame 38

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 1F
Names
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
serotonin receptor 1F

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000866.4NP_000857.1  5-hydroxytryptamine receptor 1F

    See identical proteins and their annotated locations for NP_000857.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC119733, AC132004, BC069125, BX357988, CA942616
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    Related
    ENSP00000322924.4, ENST00000319595.5
    Conserved Domains (1) summary
    cd15334
    Location:24359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001322208.2NP_001309137.1  5-hydroxytryptamine receptor 1F

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC117513, AC119034, AC119733
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001322209.2NP_001309138.1  5-hydroxytryptamine receptor 1F

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC117513, AC119034, AC119733
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001322210.2NP_001309139.1  5-hydroxytryptamine receptor 1F

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC117513, AC119034, AC119733
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    87792706..87994856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533664.2XP_011531966.1  5-hydroxytryptamine receptor 1F isoform X1

    See identical proteins and their annotated locations for XP_011531966.1

    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_005264751.3XP_005264808.1  5-hydroxytryptamine receptor 1F isoform X1

    See identical proteins and their annotated locations for XP_005264808.1

    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors
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