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HTR1F 5-hydroxytryptamine receptor 1F [ Homo sapiens (human) ]

Gene ID: 3355, updated on 11-Jun-2025
Official Symbol
HTR1Fprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 1Fprovided by HGNC
Primary source
HGNC:HGNC:5292
See related
Ensembl:ENSG00000179097 MIM:182134; AllianceGenome:HGNC:5292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5HT6; MR77; 5-HT1F; HTR1EL; 5-HT-1F
Summary
Enables Gi/o-coupled serotonin receptor activity; serotonin binding activity; and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Try the new Transcript table
See HTR1F in Genome Data Viewer
Location:
3p11.2-p11.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (87792706..87993839)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (87868616..88069681)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (87841856..88042989)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377198 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:87775589-87776580 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:87776581-87777572 Neighboring gene RNA, U6 small nuclear 873, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr3.2983 Neighboring gene CRISPRi-validated cis-regulatory element chr3.2985 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:87963222-87964421 Neighboring gene RNA, U6atac small nuclear 6, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14546 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:88094831-88096030 Neighboring gene uncharacterized LOC128031834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14547 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:88108555-88109114 Neighboring gene CGG triplet repeat binding protein 1 Neighboring gene zinc finger protein 654 Neighboring gene chromobox 5 pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients. Maassen VanDenBrink A, et al. Am J Med Genet, 1998 Jun 5. PMID 9632173
  2. The 5-hydroxytryptamine receptor 1F stimulates mitochondrial biogenesis and angiogenesis in endothelial cells. Dupre TV, et al. Biochem Pharmacol, 2019 Nov. PMID 31542386, Free PMC Article
  3. Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells. Almaça J, et al. Cell Rep, 2016 Dec 20. PMID 28009296, Free PMC Article
  4. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Lovenberg TW, et al. Proc Natl Acad Sci U S A, 1993 Mar 15. PMID 8384716, Free PMC Article
  5. Inactive and active state structures template selective tools for the human 5-HT(5A) receptor. Zhang S, et al. Nat Struct Mol Biol, 2022 Jul. PMID 35835867, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. stimulation of 5-HT1F receptor is involved in mitochondrial biogenesis in endothelial cells.
    Title: The 5-hydroxytryptamine receptor 1F stimulates mitochondrial biogenesis and angiogenesis in endothelial cells.
  2. Supporting this model, pharmacological activation of 5-HT1F receptors reduces glucagon secretion and has hypoglycemic effects in diabetic mice. Thus, modulation of serotonin signaling in the islet represents a drug intervention opportunity
    Title: Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells.
  3. 5-HT6 show no striking effects on executive function in the Chinese Han population.
    Title: Association analysis of TPH2, 5-HT2A, and 5-HT6 with executive function in a young Chinese Han population.
  4. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association study of the serotoninergic system in migraine in the Spanish population.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled serotonin receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables Gi/o-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Gi/o-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables serotonin binding IEA
Inferred from Electronic Annotation
more info
  
enables serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adenylate cyclase-inhibiting serotonin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
5-hydroxytryptamine receptor 1F
Names
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
serotonin receptor 1F

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000866.5 → NP_000857.1  5-hydroxytryptamine receptor 1F

    See identical proteins and their annotated locations for NP_000857.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC119733, AC132004, BC069125, BX357988, CA942616
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    UniProtKB/TrEMBL
    Q9P2Q4
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001322208.2 → NP_001309137.1  5-hydroxytryptamine receptor 1F

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC117513, AC119034, AC119733
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    UniProtKB/TrEMBL
    Q9P2Q4
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001322209.2 → NP_001309138.1  5-hydroxytryptamine receptor 1F

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC117513, AC119034, AC119733
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    UniProtKB/TrEMBL
    Q9P2Q4
    Related
    ENSP00000322924.4, ENST00000319595.7
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001322210.2 → NP_001309139.1  5-hydroxytryptamine receptor 1F

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC117513, AC119034, AC119733
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    UniProtKB/TrEMBL
    Q9P2Q4
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    87792706..87993839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533664.3 → XP_011531966.1  5-hydroxytryptamine receptor 1F isoform X1

    See identical proteins and their annotated locations for XP_011531966.1

    UniProtKB/Swiss-Prot
    P30939
    UniProtKB/TrEMBL
    Q9P2Q4
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_005264751.4 → XP_005264808.1  5-hydroxytryptamine receptor 1F isoform X1

    See identical proteins and their annotated locations for XP_005264808.1

    UniProtKB/Swiss-Prot
    P30939
    UniProtKB/TrEMBL
    Q9P2Q4
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    87868616..88069681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346412.1 → XP_054202387.1  5-hydroxytryptamine receptor 1F isoform X1

    UniProtKB/Swiss-Prot
    P30939
    UniProtKB/TrEMBL
    Q9P2Q4

  2. XM_054346413.1 → XP_054202388.1  5-hydroxytryptamine receptor 1F isoform X1

    UniProtKB/Swiss-Prot
    P30939
    UniProtKB/TrEMBL
    Q9P2Q4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30939.1 GenPept UniProtKB/Swiss-Prot:P30939

Gene LinkOut

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