Sign in to NCBI
Format

Send to:

Choose Destination

HTR1F 5-hydroxytryptamine receptor 1F [ Homo sapiens (human) ]

Gene ID: 3355, updated on 1-Jun-2020

Summary

Go to the top of the page Help
Official Symbol
HTR1Fprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 1Fprovided by HGNC
Primary source
HGNC:HGNC:5292
See related
Ensembl:ENSG00000179097 MIM:182134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5HT6; MR77; 5-HT1F; HTR1EL; 5-HT-1F
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all

Genomic context

Go to the top of the page Help
See HTR1F in Genome Data Viewer
Location:
3p11.2-p11.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (87792706..87994856)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (87841929..88043964)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377198 Neighboring gene RNA, U6 small nuclear 873, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr3.2983 Neighboring gene CRISPRi-validated cis-regulatory element chr3.2985 Neighboring gene RNA, U6atac small nuclear 6, pseudogene Neighboring gene CGG triplet repeat binding protein 1 Neighboring gene zinc finger protein 654 Neighboring gene chromobox 5 pseudogene 1 Neighboring gene chromosome 3 open reading frame 38

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients. Maassen VanDenBrink A, et al. Am J Med Genet, 1998 Jun 5. PMID 9632173
  2. Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells. Almaça J, et al. Cell Rep, 2016 Dec 20. PMID 28009296, Free PMC Article
  3. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Lovenberg TW, et al. Proc Natl Acad Sci U S A, 1993 Mar 15. PMID 8384716, Free PMC Article
  4. Association analysis of TPH2, 5-HT2A, and 5-HT6 with executive function in a young Chinese Han population. Gong P, et al. J Neurogenet, 2011 Mar. PMID 21457069
  5. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. Klein MT, et al. J Pharmacol Exp Ther, 2011 Jun. PMID 21422162, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Supporting this model, pharmacological activation of 5-HT1F receptors reduces glucagon secretion and has hypoglycemic effects in diabetic mice. Thus, modulation of serotonin signaling in the islet represents a drug intervention opportunity
    Title: Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells.
  2. 5-HT6 show no striking effects on executive function in the Chinese Han population.
    Title: Association analysis of TPH2, 5-HT2A, and 5-HT6 with executive function in a young Chinese Han population.
  3. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association study of the serotoninergic system in migraine in the Spanish population.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
serotonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
plasma membrane TAS
Traceable Author Statement
more info
  
synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
5-hydroxytryptamine receptor 1F
Names
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
serotonin receptor 1F

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000866.4 → NP_000857.1  5-hydroxytryptamine receptor 1F

    See identical proteins and their annotated locations for NP_000857.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC119733, AC132004, BC069125, BX357988, CA942616
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    Related
    ENSP00000322924.4, ENST00000319595.5
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001322208.2 → NP_001309137.1  5-hydroxytryptamine receptor 1F

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC117513, AC119034, AC119733
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001322209.2 → NP_001309138.1  5-hydroxytryptamine receptor 1F

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC117513, AC119034, AC119733
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001322210.2 → NP_001309139.1  5-hydroxytryptamine receptor 1F

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC117513, AC119034, AC119733
    Consensus CDS
    CCDS2920.1
    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    87792706..87994856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533664.2 → XP_011531966.1  5-hydroxytryptamine receptor 1F isoform X1

    See identical proteins and their annotated locations for XP_011531966.1

    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_005264751.3 → XP_005264808.1  5-hydroxytryptamine receptor 1F isoform X1

    See identical proteins and their annotated locations for XP_005264808.1

    UniProtKB/Swiss-Prot
    P30939
    Conserved Domains (1) summary
    cd15334
    Location:24 → 359
    7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30939.1 GenPept UniProtKB/Swiss-Prot:P30939

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous
You are here: NCBI > Genes & Expression > Gene
Support Center