Htr1f 5-hydroxytryptamine (serotonin) receptor 1F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr1fprovided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 1Fprovided by MGI
Primary source: MGI:MGI:99842
See related: Ensembl:ENSMUSG00000050783 AllianceGenome:MGI:99842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Htr1eb
Summary: Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and mammary gland. Orthologous to human HTR1F (5-hydroxytryptamine receptor 1F). [provided by Alliance of Genome Resources, May 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 16 C1.3; 16 37.1 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (64745092..64926147, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (64924729..65105784, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the 5-HT1F receptor is a component of physiological mitochondrial biogenesisregulation in the kidney, and its absence potentiates renal injury and impedes recovery
Title: 5-HT(1F) receptor regulates mitochondrial homeostasis and its loss potentiates acute kidney injury and impairs renal recovery.
Supporting this model, pharmacological activation of 5-HT1F receptors reduces glucagon secretion and has hypoglycemic effects in diabetic mice. Thus, modulation of serotonin signaling in the islet represents a drug intervention opportunity
Title: Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells.
5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.
Title: 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (4)

General gene information

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Markers

Htr1f (e-PCR), detects polymorphism
- UniSTS:143419

Htr1f (e-PCR), detects polymorphism
- UniSTS:143420

Htr1f (e-PCR), detects polymorphism
- UniSTS:495965

10.MMHAP42FRD7.seq (e-PCR)
- UniSTS:123029

Z14224 (e-PCR)
- UniSTS:163576

D16Ium74 (e-PCR), detects polymorphism
- UniSTS:142073

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables Gi/o-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables serotonin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1F

Names: 5-HT-1E-beta; 5-HT-1F; 5-HT1F; 5-hydroxytryptamine (serotonin) receptor 1E beta; serotonin receptor 1F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008310.3 → NP_032336.1 5-hydroxytryptamine receptor 1F

See identical proteins and their annotated locations for NP_032336.1

Status: VALIDATED

Source sequence(s)

AK045364

Consensus CDS

CCDS28267.1

UniProtKB/Swiss-Prot

Q02284

UniProtKB/TrEMBL

Q543V2

Related

ENSMUSP00000063136.5, ENSMUST00000063076.6

Conserved Domains (2) summary

pfam00001
Location:41 → 347

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:33 → 155

7tm_4; Olfactory receptor