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NDST1 N-deacetylase and N-sulfotransferase 1 [ Homo sapiens (human) ]

Gene ID: 3340, updated on 7-Dec-2018

Summary

Official Symbol
NDST1provided by HGNC
Official Full Name
N-deacetylase and N-sulfotransferase 1provided by HGNC
Primary source
HGNC:HGNC:7680
See related
Ensembl:ENSG00000070614 MIM:600853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSST; NST1; MRT46
Summary
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in spleen (RPKM 12.3), lung (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See NDST1 in Genome Data Viewer
Location:
5q33.1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (150485783..150558211)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149865365..149937773)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CD74 molecule Neighboring gene ribosomal protein S14 Neighboring gene NDST1 antisense RNA 1 Neighboring gene synaptopodin Neighboring gene myozenin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (NDST1) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine deacetylase activity TAS
Traceable Author Statement
more info
 
[heparan sulfate]-glucosamine N-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
[heparan sulfate]-glucosamine N-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
[heparan sulfate]-glucosamine N-sulfotransferase activity TAS
Traceable Author Statement
more info
 
deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparan sulfate N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparan sulfate N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
heparan sulfate sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Names
HSNST 1
N-Deacetylase-N-sulfotransferase 1
N-HSST 1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
N-deacetylase/N-sulfotransferase 1
N-heparan sulfate sulfotransferase 1
NDST-1
[Heparan sulfate]-glucosamine N-sulfotransferase 1
glucosaminyl N-deacetylase/N-sulfotransferase 1
heparan sulfate-N-deacetylase/N-sulfotransferase
heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase 1
NP_001287992.1
NP_001534.1
XP_005268490.1
XP_005268491.1
XP_005268492.1
XP_005268493.1
XP_005268494.1
XP_005268495.1
XP_005268496.1
XP_005268498.1
XP_005268499.1
XP_006714845.1
XP_006714846.1
XP_011535940.1
XP_016864916.1
XP_016864917.1
XP_016864918.1
XP_016864919.1
XP_016864920.1
XP_016864921.1
XP_016864922.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041806.1 RefSeqGene

    Range
    15335..65434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001301063.1NP_001287992.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001287992.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC011383, AK293746, ES315645, U18918
    Consensus CDS
    CCDS75358.1
    UniProtKB/Swiss-Prot
    P52848
    UniProtKB/TrEMBL
    B7Z1Q0, E7EVJ3
    Related
    ENSP00000428604.1, ENST00000523767.5
    Conserved Domains (2) summary
    pfam00685
    Location:605798
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  2. NM_001543.5NP_001534.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC011383, AK292448, U18918, U36600
    Consensus CDS
    CCDS34277.1
    UniProtKB/Swiss-Prot
    P52848
    UniProtKB/TrEMBL
    A8K8T3
    Related
    ENSP00000261797.6, ENST00000261797.6
    Conserved Domains (2) summary
    pfam00685
    Location:605855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    150485783..150558211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268435.4XP_005268492.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005268492.1

    Conserved Domains (2) summary
    pfam00685
    Location:605845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  2. XM_017009428.1XP_016864917.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    P52848
    Conserved Domains (2) summary
    pfam00685
    Location:605855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  3. XM_005268433.1XP_005268490.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005268490.1

    Conserved Domains (2) summary
    pfam00685
    Location:605845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  4. XM_006714783.1XP_006714846.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_006714846.1

    UniProtKB/Swiss-Prot
    P52848
    Conserved Domains (2) summary
    pfam00685
    Location:605855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  5. XM_005268438.1XP_005268495.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X3

    Conserved Domains (2) summary
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
    cl21551
    Location:605788
    Sulfotransfer_1; Sulfotransferase domain
  6. XM_005268439.1XP_005268496.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X4

    See identical proteins and their annotated locations for XP_005268496.1

    UniProtKB/TrEMBL
    E7EVJ3
    Conserved Domains (2) summary
    pfam00685
    Location:605798
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  7. XM_005268441.1XP_005268498.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X7

    Conserved Domains (1) summary
    pfam12062
    Location:30417
    HSNSD; heparan sulfate-N-deacetylase
  8. XM_011537638.2XP_011535940.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X5

    Conserved Domains (2) summary
    pfam00685
    Location:276516
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:1186
    HSNSD; heparan sulfate-N-deacetylase
  9. XM_005268437.5XP_005268494.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005268494.1

    Conserved Domains (2) summary
    pfam00685
    Location:605845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  10. XM_017009429.2XP_016864918.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    P52848
    Conserved Domains (2) summary
    pfam00685
    Location:605855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  11. XM_017009427.1XP_016864916.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    Conserved Domains (2) summary
    pfam00685
    Location:605845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  12. XM_005268434.2XP_005268491.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005268491.1

    Conserved Domains (2) summary
    pfam00685
    Location:605845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  13. XM_017009431.1XP_016864920.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    P52848
    Conserved Domains (2) summary
    pfam00685
    Location:605855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  14. XM_005268436.3XP_005268493.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005268493.1

    Conserved Domains (2) summary
    pfam00685
    Location:605845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  15. XM_006714782.2XP_006714845.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006714845.1

    Conserved Domains (2) summary
    pfam00685
    Location:605845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  16. XM_017009430.2XP_016864919.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    P52848
    Conserved Domains (2) summary
    pfam00685
    Location:605855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30515
    HSNSD; heparan sulfate-N-deacetylase
  17. XM_005268442.4XP_005268499.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X8

    Conserved Domains (2) summary
    pfam00685
    Location:181421
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:191
    HSNSD; heparan sulfate-N-deacetylase
  18. XM_017009432.1XP_016864921.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X5

    Conserved Domains (2) summary
    pfam00685
    Location:276516
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:1186
    HSNSD; heparan sulfate-N-deacetylase
  19. XM_017009433.1XP_016864922.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X6

RNA

  1. XR_245854.2 RNA Sequence

  2. XR_001742061.1 RNA Sequence

  3. XR_001742060.2 RNA Sequence

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