HSP90AB1 heat shock protein 90 alpha family class B member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSP90AB1provided by HGNC
Official Full Name: heat shock protein 90 alpha family class B member 1provided by HGNC
Primary source: HGNC:HGNC:5258
See related: Ensembl:ENSG00000096384 MIM:140572
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSP84; HSPC2; HSPCB; D6S182; HSP90B
Summary: This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
Expression: Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109.20210226	current	GRCh38.p13 (GCF_000001405.39)	6	NC_000006.12 (44246194..44253883)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (44213931..44221620)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations.
Title: Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations.
Molecular basis of the interaction of Hsp90 with its co-chaperone Hop.
Title: Molecular basis of the interaction of Hsp90 with its co-chaperone Hop.
Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target.
Title: Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target.
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
Title: USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids.
Title: Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids.
Through a proteomics screen, we identified the heat shock protein 90 B (hsp90B) chaperone as a direct MAST1 binding partner essential for its stabilization. Targeting hsp90B sensitized cancer cells to cisplatin predominantly through MAST1 destabilization. Mechanistically, interaction of hsp90B with MAST1 blocked ubiquitination of MAST1 at lysines 317 and 545.
Title: Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation.
Serum Hsp90beta and total Hsp90 levels were statistically significantly higher in overweight and obese children compared to controls. Also, Hsp90beta levels were higher in overweight and obese NAFLD patients. However Hsp90alpha to Hsp90beta ratio had better accuracy for NAFLD diagnosis in obese and overweight patients compared to individual biomarkers.
Title: Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.
The genomic region between SLC29A1 and HSP90AB1 and its role in regulating adenosine signaling are key targets for further investigation into the pathogenesis of bevacizumab-induced hypertension.
Title: Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance).
Elevated expression of HSP90alpha and HSP90beta was found to correlate with poor prognosis of head and neck cancers cases. Thus, elevated levels HSP90alpha and HSP90beta in secreted vesicles are potential prognostic biomarkers and therapeutic targets in metastatic oral squamous cell carcinoma.
Title: HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells.
Fibroblasts isolated from pulmonary fibrosis lesions showed heightened Hsp90 ATPase activity compared with normal fibroblasts. The loss of the Hsp90AB, but not the Hsp90AA isoform, resulted in reduced fibroblast proliferation, myofibroblast transformation, and ECM production.
Title: Hsp90 regulation of fibroblast activation in pulmonary fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Gag-Pol	gag-pol	HSP90 is incorporated into HIV-1 GagPol virus-like particles	PubMed
Pr55(Gag)	gag	HSP90 is incorporated into HIV-1 Gag virus-like particles	PubMed
Tat	tat	HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells	PubMed
	tat	Expression of HIV-1 Tat upregulates the abundance of heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1) in the nucleoli of Jurkat T-cells	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock protein 90kDa, class B member 1 (HSP90AB1) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed
capsid	gag	Reduced infectivity of HIV-1 CA mutants can be rescued by HSP90AB1 overexpression. Hyperthermia-induced expression of HSP90AB1 rescues CA-mutant infectivity in nonactivated cells	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1: beta; 84 kDa) at amino acid residues 483-484 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH65822 (e-PCR)
- UniSTS:51238

MARC_6805-6806:992007483:1 (e-PCR)
- UniSTS:231275

A006I17 (e-PCR)
- UniSTS:78717

GDB:451694 (e-PCR)
- UniSTS:157348

WI-8585 (e-PCR)
- UniSTS:68559

RH67971 (e-PCR)
- UniSTS:90331

Homology

Homologs of the HSP90AB1 gene: The HSP90AB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 338 organisms have orthologs with human gene HSP90AB1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ATP binding	IDA Inferred from Direct Assay more info	PubMed
ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
ATP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
CTP binding	IEA Inferred from Electronic Annotation more info
DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
GTP binding	IEA Inferred from Electronic Annotation more info
MHC class II protein complex binding	HDA more info	PubMed
RNA binding	HDA more info	PubMed
TPR domain binding	ISS Inferred from Sequence or Structural Similarity more info
UTP binding	IEA Inferred from Electronic Annotation more info
cadherin binding	HDA more info	PubMed
dATP binding	IEA Inferred from Electronic Annotation more info
disordered domain specific binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
drug binding	IEA Inferred from Electronic Annotation more info
heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
histone methyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
ion channel binding	IEA Inferred from Electronic Annotation more info
kinase binding	IPI Inferred from Physical Interaction more info	PubMed
nitric-oxide synthase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
peptide binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein folding chaperone	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase binding	IEA Inferred from Electronic Annotation more info
protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
sulfonylurea receptor binding	IEA Inferred from Electronic Annotation more info
tau protein binding	NAS Non-traceable Author Statement more info	PubMed
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
axon extension	ISS Inferred from Sequence or Structural Similarity more info
cellular response to drug	IEA Inferred from Electronic Annotation more info
cellular response to heat	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to interleukin-4	IEA Inferred from Electronic Annotation more info
cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
central nervous system neuron axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
chaperone-mediated protein complex assembly	IDA Inferred from Direct Assay more info	PubMed
establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell cycle arrest	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of complement-dependent cytotoxicity	IEA Inferred from Electronic Annotation more info
negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of transforming growth factor beta activation	IDA Inferred from Direct Assay more info	PubMed
neutrophil degranulation	TAS Traceable Author Statement more info
placenta development	IEA Inferred from Electronic Annotation more info
positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell size	IEA Inferred from Electronic Annotation more info
positive regulation of cyclin-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein binding	IEA Inferred from Electronic Annotation more info
positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
positive regulation of protein kinase B signaling	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
positive regulation of tau-protein kinase activity	IC Inferred by Curator more info
positive regulation of telomerase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
protein folding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein stabilization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein stabilization	TAS Traceable Author Statement more info
regulation of cellular protein localization	ISS Inferred from Sequence or Structural Similarity more info
regulation of cellular response to heat	TAS Traceable Author Statement more info
regulation of interferon-gamma-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
response to cocaine	IEA Inferred from Electronic Annotation more info
response to salt stress	IEA Inferred from Electronic Annotation more info
response to unfolded protein	NAS Non-traceable Author Statement more info	PubMed
supramolecular fiber organization	IMP Inferred from Mutant Phenotype more info	PubMed
telomerase holoenzyme complex assembly	IDA Inferred from Direct Assay more info	PubMed
telomere maintenance via telomerase	IDA Inferred from Direct Assay more info	PubMed
virion attachment to host cell	IMP Inferred from Mutant Phenotype more info	PubMed
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
colocalizes_with COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
HSP90-CDC37 chaperone complex	IDA Inferred from Direct Assay more info	PubMed
apical plasma membrane	IEA Inferred from Electronic Annotation more info
aryl hydrocarbon receptor complex	IDA Inferred from Direct Assay more info	PubMed
axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
brush border membrane	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
dendritic growth cone	ISS Inferred from Sequence or Structural Similarity more info
extracellular exosome	HDA more info	PubMed
extracellular region	IDA Inferred from Direct Assay more info	PubMed
extracellular region	TAS Traceable Author Statement more info
ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
inclusion body	IEA Inferred from Electronic Annotation more info
lysosomal membrane	IEA Inferred from Electronic Annotation more info
melanosome	IEA Inferred from Electronic Annotation more info
membrane	HDA more info	PubMed
mitochondrion	HDA more info	PubMed
neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
ooplasm	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
secretory granule lumen	TAS Traceable Author Statement more info
sperm head plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock protein HSP 90-beta

Names: HSP90-beta; heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271969.2 → NP_001258898.1 heat shock protein HSP 90-beta isoform a

See identical proteins and their annotated locations for NP_001258898.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2 and 3 encode the same protein (isoform a).

Source sequence(s)

AY359878, BQ028821

Consensus CDS

CCDS4909.1

UniProtKB/Swiss-Prot

P08238

UniProtKB/TrEMBL

A0A024RD80

Related

ENSP00000325875.3, ENST00000353801.7

Conserved Domains (1) summary

PTZ00272
Location:14 → 724

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
NM_001271970.2 → NP_001258899.1 heat shock protein HSP 90-beta isoform a

See identical proteins and their annotated locations for NP_001258899.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).

Source sequence(s)

BC004928, BE539681, BX420114, DC341882

Consensus CDS

CCDS4909.1

UniProtKB/Swiss-Prot

P08238

UniProtKB/TrEMBL

A0A024RD80

Related

ENSP00000481908.1, ENST00000620073.4

Conserved Domains (1) summary

PTZ00272
Location:14 → 724

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
NM_001271971.2 → NP_001258900.1 heat shock protein HSP 90-beta isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and two alternate in-frame splice sides in the coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.

Source sequence(s)

BC004928, BE539681, BG482327, DC350708

UniProtKB/Swiss-Prot

P08238

Conserved Domains (2) summary

PTZ00272
Location:14 → 676

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:143 → 666

HSP90; Hsp90 protein
NM_001271972.2 → NP_001258901.1 heat shock protein HSP 90-beta isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and uses an alternate in-frame splice site in the internal coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.

Source sequence(s)

AK294643, BC007327, BE539681

UniProtKB/TrEMBL

B4DGL0, Q6PK50

Conserved Domains (3) summary

PTZ00272
Location:14 → 714

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:181 → 704

HSP90; Hsp90 protein

pfam02518
Location:40 → 178

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
NM_001371238.1 → NP_001358167.1 heat shock protein HSP 90-beta isoform a

Status: REVIEWED

Source sequence(s)

AL139392

Related

ENSP00000360609.1, ENST00000371554.2

Conserved Domains (1) summary

PTZ00272
Location:14 → 724

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
NM_007355.4 → NP_031381.2 heat shock protein HSP 90-beta isoform a

See identical proteins and their annotated locations for NP_031381.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).

Source sequence(s)

BC004928, BE539681, DC340766

Consensus CDS

CCDS4909.1

UniProtKB/Swiss-Prot

P08238

UniProtKB/TrEMBL

A0A024RD80

Related

ENSP00000360709.5, ENST00000371646.10

Conserved Domains (1) summary

PTZ00272
Location:14 → 724

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p13 Primary Assembly

Range

44246194..44253883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_073528.1: Suppressed sequence

Description

NR_073528.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.