HSP90AB1 heat shock protein 90 alpha family class B member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSP90AB1provided by HGNC
Official Full Name: heat shock protein 90 alpha family class B member 1provided by HGNC
Primary source: HGNC:HGNC:5258
See related: Ensembl:ENSG00000096384 MIM:140572; AllianceGenome:HGNC:5258
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSP84; HSPC2; HSPCB; D6S182; HSP90B
Summary: This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
Expression: Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109.20211119	current	GRCh38.p13 (GCF_000001405.39)	6	NC_000006.12 (44246194..44253883)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (44213931..44221620)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP90 expression and early recurrence in gastroenteropancreatic neuroendocrine tumors: Potential for a novel therapeutic target.
Title: HSP90 expression and early recurrence in gastroenteropancreatic neuroendocrine tumors: Potential for a novel therapeutic target.
Protective Role of Genetic Variants in HSP90 Genes-Complex in COPD Secondary to Biomass-Burning Smoke Exposure and Non-Severe COPD Forms in Tobacco Smoking Subjects.
Title: Protective Role of Genetic Variants in HSP90 Genes-Complex in COPD Secondary to Biomass-Burning Smoke Exposure and Non-Severe COPD Forms in Tobacco Smoking Subjects.
Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer.
Title: Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer.
Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations.
Title: Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations.
Molecular basis of the interaction of Hsp90 with its co-chaperone Hop.
Title: Molecular basis of the interaction of Hsp90 with its co-chaperone Hop.
Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target.
Title: Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target.
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
Title: USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids.
Title: Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids.
Through a proteomics screen, we identified the heat shock protein 90 B (hsp90B) chaperone as a direct MAST1 binding partner essential for its stabilization. Targeting hsp90B sensitized cancer cells to cisplatin predominantly through MAST1 destabilization. Mechanistically, interaction of hsp90B with MAST1 blocked ubiquitination of MAST1 at lysines 317 and 545.
Title: Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation.
Serum Hsp90beta and total Hsp90 levels were statistically significantly higher in overweight and obese children compared to controls. Also, Hsp90beta levels were higher in overweight and obese NAFLD patients. However Hsp90alpha to Hsp90beta ratio had better accuracy for NAFLD diagnosis in obese and overweight patients compared to individual biomarkers.
Title: Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Gag-Pol	gag-pol	HSP90 is incorporated into HIV-1 GagPol virus-like particles	PubMed
Pr55(Gag)	gag	HSP90 is incorporated into HIV-1 Gag virus-like particles	PubMed
Tat	tat	HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells	PubMed
	tat	Expression of HIV-1 Tat upregulates the abundance of heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1) in the nucleoli of Jurkat T-cells	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock protein 90kDa, class B member 1 (HSP90AB1) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed
capsid	gag	Reduced infectivity of HIV-1 CA mutants can be rescued by HSP90AB1 overexpression. Hyperthermia-induced expression of HSP90AB1 rescues CA-mutant infectivity in nonactivated cells	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1: beta; 84 kDa) at amino acid residues 483-484 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH65822 (e-PCR)
- UniSTS:51238

MARC_6805-6806:992007483:1 (e-PCR)
- UniSTS:231275

A006I17 (e-PCR)
- UniSTS:78717

GDB:451694 (e-PCR)
- UniSTS:157348

WI-8585 (e-PCR)
- UniSTS:68559

RH67971 (e-PCR)
- UniSTS:90331

Homology

Homologs of the HSP90AB1 gene: The HSP90AB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 416 organisms have orthologs with human gene HSP90AB1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP hydrolysis activity	TAS Traceable Author Statement more info
enables ATP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables CTP binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables MHC class II protein complex binding	HDA more info	PubMed
enables RNA binding	HDA more info	PubMed
enables TPR domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables UTP binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	HDA more info	PubMed
enables dATP binding	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone methyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nitric-oxide synthase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables sulfonylurea receptor binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	NAS Non-traceable Author Statement more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to heat	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to interleukin-4	IEA Inferred from Electronic Annotation more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in central nervous system neuron axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chaperone-mediated protein complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of complement-dependent cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transforming growth factor beta activation	IDA Inferred from Direct Assay more info	PubMed
involved_in placenta development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cyclin-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein binding	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein kinase B signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tau-protein kinase activity	IC Inferred by Curator more info
involved_in positive regulation of telomerase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of interferon-gamma-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to salt stress	IEA Inferred from Electronic Annotation more info
involved_in response to unfolded protein	NAS Non-traceable Author Statement more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in supramolecular fiber organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomerase holoenzyme complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in telomere maintenance via telomerase	IDA Inferred from Direct Assay more info	PubMed
involved_in virion attachment to host cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of HSP90-CDC37 chaperone complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
part_of aryl hydrocarbon receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in inclusion body	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in ooplasm	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in secretory granule lumen	TAS Traceable Author Statement more info
located_in sperm head plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock protein HSP 90-beta

Names: HSP90-beta; heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271969.2 → NP_001258898.1 heat shock protein HSP 90-beta isoform a

See identical proteins and their annotated locations for NP_001258898.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2 and 3 encode the same protein (isoform a).

Source sequence(s)

AY359878, BQ028821

Consensus CDS

CCDS4909.1

UniProtKB/Swiss-Prot

P08238

UniProtKB/TrEMBL

A0A024RD80

Related

ENSP00000325875.3, ENST00000353801.7

Conserved Domains (1) summary

PTZ00272
Location:14 → 724

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
NM_001271970.2 → NP_001258899.1 heat shock protein HSP 90-beta isoform a

See identical proteins and their annotated locations for NP_001258899.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).

Source sequence(s)

BC004928, BE539681, BX420114, DC341882

Consensus CDS

CCDS4909.1

UniProtKB/Swiss-Prot

P08238

UniProtKB/TrEMBL

A0A024RD80

Related

ENSP00000481908.1, ENST00000620073.4

Conserved Domains (1) summary

PTZ00272
Location:14 → 724

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
NM_001271971.2 → NP_001258900.1 heat shock protein HSP 90-beta isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and two alternate in-frame splice sides in the coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.

Source sequence(s)

BC004928, BE539681, BG482327, DC350708

UniProtKB/Swiss-Prot

P08238

Conserved Domains (2) summary

PTZ00272
Location:14 → 676

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:143 → 666

HSP90; Hsp90 protein
NM_001271972.2 → NP_001258901.1 heat shock protein HSP 90-beta isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and uses an alternate in-frame splice site in the internal coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.

Source sequence(s)

AK294643, BC007327, BE539681

UniProtKB/TrEMBL

B4DGL0, Q6PK50

Conserved Domains (3) summary

PTZ00272
Location:14 → 714

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:181 → 704

HSP90; Hsp90 protein

pfam02518
Location:40 → 178

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
NM_001371238.1 → NP_001358167.1 heat shock protein HSP 90-beta isoform a

Status: REVIEWED

Source sequence(s)

AL139392

Related

ENSP00000360609.1, ENST00000371554.2

Conserved Domains (1) summary

PTZ00272
Location:14 → 724

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
NM_007355.4 → NP_031381.2 heat shock protein HSP 90-beta isoform a

See identical proteins and their annotated locations for NP_031381.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).

Source sequence(s)

BC004928, BE539681, DC340766

Consensus CDS

CCDS4909.1

UniProtKB/Swiss-Prot

P08238

UniProtKB/TrEMBL

A0A024RD80

Related

ENSP00000360709.5, ENST00000371646.10

Conserved Domains (1) summary

PTZ00272
Location:14 → 724

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p13 Primary Assembly

Range

44246194..44253883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_073528.1: Suppressed sequence

Description

NR_073528.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.