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HSP90AB1 heat shock protein 90 alpha family class B member 1 [ Homo sapiens (human) ]

Gene ID: 3326, updated on 29-Mar-2020

Summary

Official Symbol
HSP90AB1provided by HGNC
Official Full Name
heat shock protein 90 alpha family class B member 1provided by HGNC
Primary source
HGNC:HGNC:5258
See related
Ensembl:ENSG00000096384 MIM:140572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP84; HSPC2; HSPCB; D6S182; HSP90B
Summary
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues See more
Orthologs

Genomic context

See HSP90AB1 in Genome Data Viewer
Location:
6p21.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (44246166..44253888)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44213903..44221625)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene myomixer, myoblast fusion factor Neighboring gene RNA, 7SL, cytoplasmic 811, pseudogene Neighboring gene solute carrier family 29 member 1 (Augustine blood group) Neighboring gene solute carrier family 35 member B2 Neighboring gene microRNA 4647 Neighboring gene NFKB inhibitor epsilon

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
Tat tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
tat Expression of HIV-1 Tat upregulates the abundance of heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1) in the nucleoli of Jurkat T-cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock protein 90kDa, class B member 1 (HSP90AB1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
capsid gag Reduced infectivity of HIV-1 CA mutants can be rescued by HSP90AB1 overexpression. Hyperthermia-induced expression of HSP90AB1 rescues CA-mutant infectivity in nonactivated cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1: beta; 84 kDa) at amino acid residues 483-484 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26984

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ATPase activity TAS
Traceable Author Statement
more info
 
CTP binding IEA
Inferred from Electronic Annotation
more info
 
DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
MHC class II protein complex binding HDA PubMed 
RNA binding HDA PubMed 
TPR domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
UTP binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
dATP binding IEA
Inferred from Electronic Annotation
more info
 
disordered domain specific binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone methyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
nitric-oxide synthase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
peptide binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in protein folding IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
sulfonylurea receptor binding IEA
Inferred from Electronic Annotation
more info
 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
central nervous system neuron axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
chaperone-mediated protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of complement-dependent cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transforming growth factor beta activation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
placenta development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cyclin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tau-protein kinase activity IC
Inferred by Curator
more info
 
positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein stabilization TAS
Traceable Author Statement
more info
 
regulation of cellular protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to salt stress IEA
Inferred from Electronic Annotation
more info
 
response to unfolded protein NAS
Non-traceable Author Statement
more info
PubMed 
supramolecular fiber organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomerase holoenzyme complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
virion attachment to host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
HSP90-CDC37 chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
aryl hydrocarbon receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendritic growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
inclusion body IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrion HDA PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ooplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 
sperm head plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heat shock protein HSP 90-beta
Names
HSP90-beta
heat shock 84 kDa
heat shock 90kD protein 1, beta
heat shock protein 90 kDa
heat shock protein 90kDa alpha (cytosolic), class B member 1
heat shock protein 90kDa alpha family class B member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271969.1NP_001258898.1  heat shock protein HSP 90-beta isoform a

    See identical proteins and their annotated locations for NP_001258898.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AY359878, BE539681, BQ028821, DC350708
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    P08238
    UniProtKB/TrEMBL
    A0A024RD80
    Related
    ENSP00000325875.3, ENST00000353801.7
    Conserved Domains (1) summary
    cl27733
    Location:14724
    HSP90; Hsp90 protein
  2. NM_001271970.1NP_001258899.1  heat shock protein HSP 90-beta isoform a

    See identical proteins and their annotated locations for NP_001258899.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
    Source sequence(s)
    BC004928, BE539681, BX420114, DC341882
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    P08238
    UniProtKB/TrEMBL
    A0A024RD80
    Related
    ENSP00000481908.1, ENST00000620073.4
    Conserved Domains (1) summary
    cl27733
    Location:14724
    HSP90; Hsp90 protein
  3. NM_001271971.1NP_001258900.1  heat shock protein HSP 90-beta isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and two alternate in-frame splice sides in the coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.
    Source sequence(s)
    BC004928, BE539681, BG482327, DC350708
    UniProtKB/Swiss-Prot
    P08238
    Conserved Domains (2) summary
    PTZ00272
    Location:14676
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:143666
    HSP90; Hsp90 protein
  4. NM_001271972.1NP_001258901.1  heat shock protein HSP 90-beta isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and uses an alternate in-frame splice site in the internal coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
    Source sequence(s)
    AK294643, BC007327, BE539681, DC350708
    UniProtKB/TrEMBL
    B4DGL0, Q6PK50
    Conserved Domains (3) summary
    PTZ00272
    Location:14714
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:181704
    HSP90; Hsp90 protein
    pfam02518
    Location:40178
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
  5. NM_001371238.1NP_001358167.1  heat shock protein HSP 90-beta isoform a

    Status: REVIEWED

    Source sequence(s)
    AL139392
    Related
    ENSP00000360609.1, ENST00000371554.2
  6. NM_007355.4NP_031381.2  heat shock protein HSP 90-beta isoform a

    See identical proteins and their annotated locations for NP_031381.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
    Source sequence(s)
    BC004928, BE539681, DC340766
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    P08238
    UniProtKB/TrEMBL
    A0A024RD80
    Related
    ENSP00000360709.5, ENST00000371646.10
    Conserved Domains (1) summary
    cl27733
    Location:14724
    HSP90; Hsp90 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    44246166..44253888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_073528.1: Suppressed sequence

    Description
    NR_073528.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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