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Thsd7a thrombospondin, type I, domain containing 7A [ Mus musculus (house mouse) ]

Gene ID: 330267, updated on 12-May-2024

Summary

Official Symbol
Thsd7aprovided by MGI
Official Full Name
thrombospondin, type I, domain containing 7Aprovided by MGI
Primary source
MGI:MGI:2685683
See related
Ensembl:ENSMUSG00000032625 AllianceGenome:MGI:2685683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm837
Summary
Involved in actin cytoskeleton reorganization. Located in plasma membrane and podocyte foot. Is expressed in several structures, including alimentary system; autopod; central nervous system; genitourinary system; and sensory organ. Orthologous to human THSD7A (thrombospondin type 1 domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 4.7), CNS E14 (RPKM 3.4) and 15 other tissues See more
Orthologs
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Genomic context

See Thsd7a in Genome Data Viewer
Location:
6 A1; 6 5.31 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (12311607..12749252, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (12311608..12749253, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32222 Neighboring gene predicted gene, 35961 Neighboring gene STARR-seq mESC enhancer starr_15174 Neighboring gene STARR-seq mESC enhancer starr_15175 Neighboring gene STARR-seq mESC enhancer starr_15176 Neighboring gene STARR-seq mESC enhancer starr_15177 Neighboring gene predicted gene, 38583 Neighboring gene STARR-seq mESC enhancer starr_15178 Neighboring gene STARR-seq mESC enhancer starr_15179 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 11 Neighboring gene STARR-seq mESC enhancer starr_15182 Neighboring gene STARR-seq mESC enhancer starr_15184 Neighboring gene STARR-seq mESC enhancer starr_15185 Neighboring gene HORMA domain containing 1 pseudogene Neighboring gene predicted gene, 18221

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in podocyte foot IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thrombospondin type-1 domain-containing protein 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164805.1NP_001158277.1  thrombospondin type-1 domain-containing protein 7A precursor

    Status: VALIDATED

    Source sequence(s)
    AC122394, AK133324, AK136087, AK164834, BB656281, BC052230, DV653338
    Consensus CDS
    CCDS51721.1
    UniProtKB/Swiss-Prot
    Q3TP01, Q3UWV1, Q69ZU6
    UniProtKB/TrEMBL
    E9Q6P0, E9QNR5
    Related
    ENSMUSP00000113681.3, ENSMUST00000119581.7
    Conserved Domains (2) summary
    smart00209
    Location:186236
    TSP1; Thrombospondin type 1 repeats
    cl15278
    Location:353404
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    12311607..12749252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)